Abstract: The present invention provides for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE.

Abstract: The present application relates to an antibacterial dressing including an antibacterial composition. The antibacterial composition includes a biguanidine antibacterial agent, a zinc-containing compound, and a magnesium-containing compound with a mass ratio of (0.02 to 1):(0.1 to 0.5):(1 to 5). The antibacterial dressing could be applied onto a skin wound for promoting would healing.

Abstract: This document provides derivatized C60 molecules (e.g., C60-serinol) and methods and materials for using derivatized C60 molecules (e.g., C60-serinol) to reduce radiation injury. For example, methods and materials for using derivatized C60 molecules (e.g., C60-serinol) to reduce, prevent, and/or mitigate radiation injury (e.g., radiation induced oxidative stress and/or DNA damage) to cells (e.g., human cells) or to a mammal (e.g., a human) during, for example, outer space missions are provided.

Abstract: The present disclosure generally relates to compositions and techniques for vaginal insertion. In some embodiments, a composition such as a gel may be applied to the vagina of a subject that is relatively viscous, for example, with a viscosity at room temperature of at least 1.5 million cP. The composition may also contain an active ingredient, e.g., dinoprostone, diclofenac, and/or salts thereof. Compositions having such relatively high viscosities may be useful, for example, to prevent the composition from readily exiting the vagina or degrading too quickly. This may, for example, allow the composition to release the active ingredient over a relatively long period of time to the vagina. In some embodiments, such compositions may be prepared by removing air from the composition to increase its viscosity or cause the composition to form a gel, etc.

Abstract: The present invention relates to a method for assessing Atenolol with precision. A pharmaceutical composition comprising: a predefined amount of Atenolol or pharmaceutically acceptable salts thereof; and a combination of pharmaceutical excipients suitable for oral administration, wherein the method for tailoring the treatment of hypertension comprises of determining the levels of C-reactive protein, blood pressure, blood urea, and HbA1c in hypertensive patients; stratifying patients into distinct subgroups based on the identified biomarker levels; and customizing antihypertensive treatment plans for each subgroup, wherein treatment may include, but is not limited to, beta blockers such as Atenolol.

Abstract: The object of the present invention is to search for a compound that may suppress the expression of TMPRSS2 in a cell or tissue. The expression of TMPRSS2 in a cell or tissue is suppressed by 5-aminolevulinic acids.

Abstract: Methods of treating a metabolic disorder in a subject are provided. Aspects of the method include administering an effective amount of an N-lactoyl-amino acid to the subject. Also provided are pharmaceutical formulations including an amount of an N-lactoyl-amino acid effective to treat a metabolic disorder. Any suitable N-lactoyl-amino acid or combination of N-lactoyl-amino acids may be administered in the subject methods.

Abstract: The present invention relates to carbamoyl phenylalaninol compounds and methods of using the same to treat disorders. The invention further relates to the development of methods for treating excessive sleepiness in a subject, e.g., due to narcolepsy or obstructive sleep apnea, with the surprising outcome that “normal” levels of wakefulness are achieved based on standard objective and subjective sleepiness tests.

Abstract: The present disclosure provides for treating neurodegenerative diseases comprising administering acetyl-leucine or a pharmaceutically acceptable salt thereof.

Abstract: A micro-magnetic invisible orthodontic appliance is provided. The micro-magnetic invisible orthodontic appliance includes a bottom brace (1), an outer periodontal brace (2) and an inner periodontal brace (3). The bottom brace (1), the outer periodontal brace (2) and the inner periodontal brace (3) together form a U-shaped brace. A tooth receiving groove is defined between the outer periodontal brace (2) and the inner periodontal brace (3). The bottom brace (1), the outer periodontal brace (2) and the inner periodontal brace (3) are made from one of a polymer composite material, biological ceramic, and an interpenetrating polymer network material, dispersed with permanent magnetic neodymium-iron-boron powder, by one-piece molding or three-dimensional printing.

Abstract: Described herein is a sesquiterpene derivative or a pharmaceutically acceptable salt thereof, a composition for preventing, ameliorating or treating sarcopenia, including the derivative or salt thereof as an active ingredient, and the like. The sesquiterpene derivative or pharmaceutically acceptable salt thereof inhibits increases in the production and mRNA expression of a myostatin protein, which directly affects muscle loss and reduced muscle strength, and thus may exhibit a more fundamental effect of preventing or treating sarcopenia.

Abstract: The instant invention provides dental aligner(s) that can be better tuned to deliver a specific and more stable (lower creep) force on the teeth while also being softer and thinner. The instant dental aligners also provide the medical practitioner greater control to customize the treatment based on a patient's therapeutic stage, discreet requirements, and pain tolerance.

Abstract: The invention relates to an invisible dental brace with pressure-sensitive sensors, comprising: a brace body, at least one pressure-sensitive sensor, and/or a processor. The brace body is designed to receive at least one corresponding tooth of an orthodontic patient and reposition said at least one corresponding tooth from an initial position towards a target position according to a prescribed orthodontic treatment plan. Said at least one pressure-sensitive sensor is configured to generate a sensor signal related to the wearing time of the brace body and a force or pressure applied to said at least one corresponding tooth by the brace body. The sensor signal is then transmitted to a cloud database for further analysis or to the processor for processing to generate a performance of the brace body. Finally, the performance is transmitted to a cloud database for an orthodontic practitioner to modify the prescribed orthodontic treatment plan.

Abstract: A dental apparatus for use in direct bonding orthodontic applications to facilitate precise positioning of orthodontic brackets on the user's teeth includes a body portion comprising first, second and third sections, where the first section is uniquely configured with a plurality of guide sections, wherein each guide section generally comprises a first wall, a second wall and a medial wall and is uniquely shaped and sized to permit the ready and accurate positioning, and direct tooth bonding, of orthodontic brackets within each guide section. Associated systems and methods are also described.

Abstract: A bone fixture with various moduli has an implant body. The implant body includes a first implanting segment adapted to be implanted into a cortical bone of a bone and a second implanting segment adapted to be implanted into a cancellous bone of the bone and located below the first implant segment. A first young's modulus of the first implanting segment is smaller than a second young's modulus of the second implanting segment. Because the first young's modulus of the first implanting segment adapted to be implanted in the cortical bone is smaller than the second young's modulus of the second implanting segment adapted to be implanted in the cancellous bone, forces applied to the bone fixture can be evenly distributed to avoid the stress concentration at the cortical bone of the bone.

Abstract: The present invention relates to a method of generating manufacturing parameters during a dental procedure to construct a dental prosthesis, the method comprising the steps of: a) intra-orally scanning a patient to generate intra-oral data; b) extra-orally scanning the patient during a mandibular motion to generate dynamic extra-oral maxillofacial data; c) resolving the intra-oral data with the dynamic extra-oral maxillofacial data to generate a combined data model; d) generating a model representation of the dental prosthesis based on the combined data model and displaying the model representation to a user; and e) generating manufacturing parameters based on the combined data model.

Abstract: A dental prosthesis processing device that processes a workpiece made of ceramic or the like into a prosthesis of a desired shape includes one or more processing tools for processing a workpiece into a prosthesis of a predetermined shape; a spindle on which the processing tools are replaceably mounted and that is spatially movable in position; a processing tool replacement obstruction part located in close proximity to the processing tools and/or the spindle and configured to obstruct the processing tools from being replaced; and a controller configured to determine whether to replace the processing tools. Depending on whether the replacement is necessary or not, the controller allows or prevents the processing tools from being replaced by bringing the processing tools and/or the spindle and the processing tool replacement obstruction part away from or close to each other.

Abstract: A method and system provide segmenting a digital tooth in a 3D digital model of dentition.

Abstract: A method of providing restorative decision support for a dental patient includes receiving image data of an intraoral cavity of a patient, the image data corresponding to one or more imaging modalities; deriving a plurality of parameters from the image data; applying a decision model to the plurality of parameters; and generating a restorative decision recommendation based on an output of the decision model.

Abstract: The invention relates to a method for configurating a split denture. A digital 3D model of the denture comprising a plurality of teeth is provided. The digital 3D model of the denture is split into a digital 3D model of a base part and a digital 3D model of a teeth part. The base part comprises a first artificial gingiva portion. Further, the base part is configured to support the teeth part. The teeth part comprises the plurality of teeth of the denture and a second gingiva portion. The teeth part is configured to be mounted on the base part. The digital 3D model of the split denture is provided for generating at least one of the base part and the teeth part.