Abstract: The present disclosure provides antibodies specific for Nectin-4 and antibody conjugates e.g., antibody-drug conjugates (ADCs), comprising such antibodies. The disclosure also encompasses methods of production of such antibodies and antibody conjugates, as well as methods of using the same. Also provided are compositions that include the antibodies and antibody conjugates of the present disclosure, including in some instances, pharmaceutical compositions. In certain aspects, provided are methods of using the ADC that include administering to an individual having a cell proliferative disorder a therapeutically effective amount of the antibodies or antibody conjugates of the present disclosure.

Abstract: An apparatus includes a first set of scan-enabled flip-flop circuits may be configured to shift a scan-chain pattern from a first test input node to a first test output node using a first clock signal. A particular lockup latch may be coupled to the first test output node and to a second test input node. This particular lockup latch may be configured to, when enabled, delay propagation of the scan-chain pattern from the first test output node to the second test input node. A second set of scan-enabled flip-flop circuits may be configured to shift the scan-chain pattern from the second test input node to a second test output node using a second clock signal, different from the first clock signal. A control circuit may be configured to determine whether to enable the particular lockup latch using a particular scan test signal.

Abstract: A surgical system includes a first surgical instrument having a selected configuration and an image guide disposed relative to a sensor to communicate a signal representative of a position of the image guide. A passive image guide is fixed with vertebral tissue and is disposed relative to the sensor to communicate a signal representative of a position of the passive image guide. The passive image guide includes a first surface. A second surgical instrument is connectable with the first surgical instrument and includes a second surface engageable with the first surface in a mating configuration to provide verification of the selected configuration. Surgical instruments, implants, spinal constructs and methods are disclosed.

Abstract: The present disclosure provides for a compound according to formula (I) or a pharmaceutically acceptable salt thereof as CaV1.22 activators for the treatment of schizophrenia, bipolar disorder, major depressive disorder, substance use disorder, ADHD, Phelan-McDermid Syndrome, autism spectrum disorder, multiple sclerosis, frontotemporal dementia, Alzheimer's disease, Brugada Syndrome, Short QT syndrome, or early repolarization syndrome.

Abstract: This present disclosure relates generally to the production of polypeptides comprised of modified ?1-?2 domains of NKG2D ligands which bind specifically to a non-natural ectodomain of a non-natural NKG2D receptor and wherein heterologous molecules are attached to the modified ?1-?2 domains of NKG2D ligands. The present disclosure further relates to modified ?1-?2 domains of NKG2D ligands attached to heterologous molecules including polypeptides, and in some embodiments, antibodies or fragments of antibodies. The present disclosure also relates to modified forms of the NKG2D receptor engineered to provide a combination of enhanced and diminished binding to non-natural and natural versions of NKG2D ligands, respectively.

Abstract: A surgical system includes a first surgical instrument having a selected configuration and an image guide disposed relative to a sensor to communicate a signal representative of a position of the image guide. A passive image guide is fixed with vertebral tissue and is disposed relative to the sensor to communicate a signal representative of a position of the passive image guide. The passive image guide includes a first surface. A second surgical instrument is connectable with the first surgical instrument and includes a second surface engageable with the first surface in a mating configuration to provide verification of the selected configuration. Surgical instruments, implants, spinal constructs and methods are disclosed.

Abstract: Disclosed herein is a device, and a method for using the device to measure the range-of-motion of a hip joint during a hip resurfacing surgery. The device comprises a temporary femoral component for rigidly affixing an array holder to the resurfaced femoral head to hold a primary array of tracking markers that are tracked through the range-of-motion by a computer-assisted surgical system (CASS).

Abstract: Methods of treating a subject in need thereof are provided which include: administering a recombinant platelet derived growth factor D (PDGF D) composition to a mesenchymal stem cell of the subject and/or a progenitor derived therefrom, in vivo, or ex vivo, producing a treated mesenchymal stem cell of the subject and/or a progenitor derived therefrom, thereby stimulating the mesenchymal stem cell (MSC) and/or a progenitor derived therefrom. Cells expressing a recombinant PDGF D composition of the present are administered to the subject for in vivo delivery of the recombinant PDGF D composition according to aspects of the present disclosure. Methods and compositions are provided including recombinant PDGF D hemidimer (HD) including a full-length PDGF D polypeptide and a C-terminal growth factor domain of PDGF D, which lacks a CUB domain, promoting regulation of bone marrow MSC differentiation into osteogenic lineage cells.

Abstract: The present disclosure relates to non-natural NKG2D receptors attached to mammalian cell surfaces wherein the non-natural receptors do not directly signal or directly activate the cell when the receptor is bound by cognate non-natural ?1-?2 domains of NKG2D ligands modified to specifically bind the non-natural NKG2D receptors. The non-natural ?1-?2 domains of NKG2D ligands may be attached to heterologous atoms or molecules including polypeptides, in some embodiments cytokines or modified cytokines, antibodies or fragments of antibodies.

Abstract: The present disclosure provides for a compound according to formula (I) or a pharmaceutically acceptable salt thereof as CaV1.22 activators for the treatment of schizophrenia, bipolar disorder, major depressive disorder, substance use disorder, ADHD, Phelan-McDermid Syndrome, autism spectrum disorder, multiple sclerosis, frontotemporal dementia, Alzheimer's disease, Brugada Syndrome, Short QT syndrome, or early repolarization syndrome.

Abstract: A series PV arc fault detection method and apparatus demodulates a current signal provided by a DC power source to an inverter to eliminate a DC component and periodic noise. Autocorrelation coefficients are generated from the demodulated current signal to monitor noise energy and variation and, based on the noise energy, a determination is made if an arc fault has occurred.

Abstract: Pink noise analysis, along with unique properties of the photovoltaic (PV) operating point of both the instantaneous current and voltage signal, is used to distinguish arc faults from other noisy loads or PV degradations.

Abstract: A surgical instrument includes a body member and a leg having a first end integrated with and extending from the body member. A head cavity is in the leg portion to hold a head. A channel is formed along a longitudinal length of the leg. An elongated rocker assembly includes an elongated lever arm coupled within the channel about a fulcrum and a spring actuation. A projection of the arm projects in a direction of the head cavity. A rocker slide lock has a collar slidably coupled around the body member and having a first position located between the body member and the actuation tab, such that a portion of the collar is under the actuation tab to limit pivotal motion of the rocker assembly, and a second position having a clearance from under the actuation tab.

Abstract: A system comprising surgical instruments of different types. Each surgical instrument includes a body member and a leg having a first end integrated with and a leg portion extending from the body member. The instrument includes a head cavity formed in a free end of the leg. The cavity holds a head. A channel is formed along a portion of a longitudinal length of the leg. The instrument includes an elongated rocker assembly pivotally coupled within the channel, with a spring actuation tab in proximity to the body member. The instrument includes a collar slidably coupled around the body member and having a first position located between the body member and the actuation tab such that a portion of the collar is under the actuation tab to limit pivotal motion of the rocker assembly and a second position of the collar has a clearance from under the actuation tab.

Abstract: A network-based service may be provided for facilitating queries for a number of items, such as travel services. A user may submit a query including criteria for determining one or more relevant items. Based on the submitted query, the network-based service may present the user with information regarding the actions of other similar users of the network-based service, such as searches performed by the other users. Based on this information, the user may elect to supplement the current query to conform to the actions for other users. In some embodiments, actions by other users may be based at least in part on a category of the querying user. By presenting actions of similar users, a current user may be enabled to select the most relevant query terms for identifying a desired item.

Abstract: A surgical system including a combination instrument for breaking of tabs of a reduction connector and providing a counter torque for a driver is disclosed. The combination instrument may have an elongated rigid structure and include an internal shaft and a magazine portion configured to store at least one tab of a reduction connector. The combination instrument may further include a cut-out portion configured to retain the at least one tab within the magazine portion. In some embodiments, the driver may be configured to be inserted into the internal shaft of the combination instrument. In some embodiments, the driver is rotatable within the internal shaft of the combination instrument and configured to drive a set screw within the reduction connector. Disclosed drivers may be manual drivers or powered drivers. Some embodiments, may include a collar or a cap from which the broken off tabs may be ejected.

Abstract: An energy storage assembly includes an energy storage unit. A supervisor is operable to determine a power reference set point based upon a cost function. A storage unit controller is configured to control the energy storage unit to provide electric energy to at least one load based upon a power reference input that is based upon the power reference set point and at least one dynamically changing power profile from the at least one load.

Abstract: A surgical system includes a first surgical instrument having a selected configuration and an image guide disposed relative to a sensor to communicate a signal representative of a position of the image guide. A passive image guide is fixed with vertebral tissue and is disposed relative to the sensor to communicate a signal representative of a position of the passive image guide. The passive image guide includes a first surface. A second surgical instrument is connectable with the first surgical instrument and includes a second surface engageable with the first surface in a mating configuration to provide verification of the selected configuration. Surgical instruments, implants, spinal constructs and methods are disclosed.

Abstract: Pink noise analysis, along with unique properties of the photovoltaic (PV) operating point of both the instantaneous current and voltage signal, is used to distinguish arc faults from other noisy loads or PV degradations.

Abstract: A surgical system including a combination instrument for breaking of tabs of a reduction connector and providing a counter torque for a driver is disclosed. The combination instrument may have an elongated rigid structure and include an internal shaft and a magazine portion configured to store at least one tab of a reduction connector. The combination instrument may further include a cut-out portion configured to retain the at least one tab within the magazine portion. In some embodiments, the driver may be configured to be inserted into the internal shaft of the combination instrument. In some embodiments, the driver is rotatable within the internal shaft of the combination instrument and configured to drive a set screw within the reduction connector. Disclosed drivers may be manual drivers or powered drivers. Some embodiments, may include a collar or a cap from which the broken off tabs may be ejected.