Abstract: The present invention relates to compositions and methods utilizing anti-TNF antibodies having a heavy chain (HC) comprising SEQ ID NO:36 and a light chain (LC) comprising SEQ ID NO:37 for use in the safe and effective treatment of active Ankylosing Spondylitis (AS).

Abstract: A vehicle drive system includes a first prime mover, a transmission, a power take-off (PTO), a lubrication system for the transmission and the PTO, and a control system. The transmission is powered by the first prime mover. The transmission is configured to rotate a drive shaft of the vehicle. The PTO is connected to the transmission at a first interface. The PTO includes the first interface and a second interface. The control system is configured to control fluid flow through the lubrication system for at least one mode where the input section of the PTO is stationary and the output section rotates.

Abstract: The present disclosure relates to non-natural NKG2D receptors attached to mammalian cell surfaces wherein the non-natural receptors do not directly signal or directly activate the cell when the receptor is bound by cognate non-natural ?1-?2 domains of NKG2D ligands modified to specifically bind the non-natural NKG2D receptors. The non-natural ?1-?2 domains of NKG2D ligands may be attached to heterologous atoms or molecules including polypeptides, in some embodiments cytokines or modified cytokines, antibodies or fragments of antibodies.

Abstract: A foldable electronic device may have a foldable housing. The foldable housing may be configured to bend about a bend axis. First and second portions of the housing that rotate relative to each other may be coupled by a hinge that is aligned with the bend axis. A foldable display may be coupled to the foldable housing and may be configured to bend along the bend axis as the foldable housing is folded. The display may have an array of pixels supported by a metal layer. The pixels may be interposed between a display cover layer and the metal layer. The foldable housing may have a support layer. To help support the display for bending about the bend axis while preventing damage to the display when the display is contacted by an external object, a spring layer may be interposed between the metal layer and the support layer.

Abstract: A sensor for formaldehyde gas, methods of making the same, and methods of using the same, are described.

Abstract: The present invention provides methods for sequencing and analysis of nucleic acids and determining that a subject is positive for a non-usual interstitial pneumonia subtype.

Abstract: An electronic device includes a processor, and a memory containing instructions that, when executed by the processor, cause the electronic device to learn a sound emitted by a legacy device and to issue an output when the electronic device subsequently hears the sound. For example, the electronic device can receive a training input and extract a compact representation of a sound in the training input, which the device stores. The device can receive an audio signal corresponding to an observed acoustic scene and extract a representation of the observed acoustic scene from the audio signal. The electronic device can determine whether the sound is present in the observed acoustic scene at least in part from a comparison of the representation of the observed acoustic scene with the representation of the sound. The electronic device emits a selected output responsive to determining that the sound is present in the acoustic scene.

Abstract: The present disclosure generally relates to user interfaces for managing locks. In some examples, an electronic device displays user interfaces for configuring a lock accessory device based on detected features of the lock accessory device, such as a short-range communication user interface for enabling an express mode of the lock accessory device and/or a pin user interface object for enabling a code for accessing the lock accessory device. In some examples, an electronic device displays a user interface corresponding to a respective user of a home automation system that includes statuses indicating whether the respective user has access to a plurality of lock accessory devices of the home automation system.

Abstract: A handheld electronic device may include a microphone for receiving voice commands, a speaker for providing audio feedback, a display for providing visual output and receiving touch input, and a motion sensor for receiving gesture input. The handheld electronic device may include control circuitry that processes voice commands differently depending on the application running on the handheld electronic device and the icon being displayed on the display. The control circuitry may determine the location of the handheld electronic device and may provide content based on the location. For example, a remote control interface for controlling an external device may be displayed when the handheld electronic device approaches the external device. A head-mounted device may display virtual images based on the location of the handheld electronic device. The virtual images may include a live video feed from a video call, virtual images associated with voice commands, or other virtual images.

Abstract: A watchband can comfortably secure an electronic device to a wrist of a user. The watchband can include a base having a contact surface opposite an engagement surface and an engagement ribbon forming loops on the engagement surface of the base for receiving a hook of a buckle. The engagement ribbon can be interwoven with the base to provide secure anchoring for the hook within one of the loops. The woven portions of the watchband can be securely coupled to end structures, such as the buckle, retaining rings, and/or a connector. The watchband provides adjustable lengths to accommodate different fit configurations as desired.

Abstract: A watchband can comfortably secure an electronic device to a wrist of a user. The watchband can include a base having a contact surface opposite an engagement surface and an engagement ribbon forming loops on the engagement surface of the base for receiving a hook of a buckle. The engagement ribbon can be interwoven with the base to provide secure anchoring for the hook within one of the loops. The woven portions of the watchband can be securely coupled to end structures, such as the buckle, retaining rings, and/or a connector. The watchband provides adjustable lengths to accommodate different fit configurations as desired.

Abstract: A foldable electronic device may bend about a bend axis. A foldable display panel may be configured to bend along the bend axis as the foldable device is folded. A display cover layer may overlap the display panel. The display panel may have an array of pixels configured to display an image viewable through the display cover layer. The display cover layer may be formed from a layer of glass. A recess may be formed in the layer of glass that runs parallel to the bend axis and that overlaps the bend axis. The recess forms a flexible locally thinned portion in the glass that allows the display cover layer to bend. A rough surface texture and polymer coating may be provided in the recess. The recess may have shallowly sloping walls.

Abstract: A watchband can comfortably secure an electronic device to a wrist of a user. The watchband can include a base having a contact surface opposite an engagement surface, contact loops on the contact surface for contacting a user, and engagement loops on the engagement surface for engaging hooks. The hooks can be provided on the engagement surface, opposite some of the contact loops. Edge sections of the base can wrap around a central section to define an end of the base. A tab can extend from an end of the base to facilitate attachment, adjustment, and/or removal of the watch band. The tab can further help maintain the assembled parts in place to enhance durability of the watchband.

Abstract: The present disclosure provides for a compound according to formula (I) or a pharmaceutically acceptable salt thereof as CaV1.22 activators for the treatment of schizophrenia, bipolar disorder, major depressive disorder, substance use disorder, ADHD, Phelan-McDermid Syndrome, autism spectrum disorder, multiple sclerosis, frontotemporal dementia, Alzheimer's disease, Brugada Syndrome, Short QT syndrome, or early repolarization syndrome.

Abstract: A series PV arc fault detection method and apparatus demodulates a current signal provided by a DC power source to an inverter to eliminate a DC component and periodic noise. Autocorrelation coefficients are generated from the demodulated current signal to monitor noise energy and variation and, based on the noise energy, a determination is made if an arc fault has occurred.

Abstract: Pink noise analysis, along with unique properties of the photovoltaic (PV) operating point of both the instantaneous current and voltage signal, is used to distinguish arc faults from other noisy loads or PV degradations.

Abstract: A surgical instrument includes a body member and a leg having a first end integrated with and extending from the body member. A head cavity is in the leg portion to hold a head. A channel is formed along a longitudinal length of the leg. An elongated rocker assembly includes an elongated lever arm coupled within the channel about a fulcrum and a spring actuation. A projection of the arm projects in a direction of the head cavity. A rocker slide lock has a collar slidably coupled around the body member and having a first position located between the body member and the actuation tab, such that a portion of the collar is under the actuation tab to limit pivotal motion of the rocker assembly, and a second position having a clearance from under the actuation tab.

Abstract: A system comprising surgical instruments of different types. Each surgical instrument includes a body member and a leg having a first end integrated with and a leg portion extending from the body member. The instrument includes a head cavity formed in a free end of the leg. The cavity holds a head. A channel is formed along a portion of a longitudinal length of the leg. The instrument includes an elongated rocker assembly pivotally coupled within the channel, with a spring actuation tab in proximity to the body member. The instrument includes a collar slidably coupled around the body member and having a first position located between the body member and the actuation tab such that a portion of the collar is under the actuation tab to limit pivotal motion of the rocker assembly and a second position of the collar has a clearance from under the actuation tab.

Abstract: A network-based service may be provided for facilitating queries for a number of items, such as travel services. A user may submit a query including criteria for determining one or more relevant items. Based on the submitted query, the network-based service may present the user with information regarding the actions of other similar users of the network-based service, such as searches performed by the other users. Based on this information, the user may elect to supplement the current query to conform to the actions for other users. In some embodiments, actions by other users may be based at least in part on a category of the querying user. By presenting actions of similar users, a current user may be enabled to select the most relevant query terms for identifying a desired item.

Abstract: A surgical system including a combination instrument for breaking of tabs of a reduction connector and providing a counter torque for a driver is disclosed. The combination instrument may have an elongated rigid structure and include an internal shaft and a magazine portion configured to store at least one tab of a reduction connector. The combination instrument may further include a cut-out portion configured to retain the at least one tab within the magazine portion. In some embodiments, the driver may be configured to be inserted into the internal shaft of the combination instrument. In some embodiments, the driver is rotatable within the internal shaft of the combination instrument and configured to drive a set screw within the reduction connector. Disclosed drivers may be manual drivers or powered drivers. Some embodiments, may include a collar or a cap from which the broken off tabs may be ejected.