Abstract: A neural processing device and a method of updating translation lookaside buffer thereof are provided. The neural processing device includes at least one processor module each of which includes at least one micro translation lookaside buffer (TLB), a hierarchical memory that is accessed by the at least one micro TLB, and a command processor configured to update the at least one micro TLB in a push mode by generating a first update signal which indicates update of the at least one micro TLB and transmitting the first update signal to the at least one micro TLB.

Abstract: Provided are a myeloid-specific promoter and a use thereof. The myeloid-specific promoter includes a nucleic acid sequence as shown in SEQ ID NO: 1 or SEQ ID NO: 2. The myeloid-specific promoter shows specificity to myeloid tissues. It initiates a gene expression with high efficiency in myeloid cells, but with relative low efficiency in non-myeloid cells. As such, the myeloid-specific promoter regulates the specific expression of a gene in myeloid tissues. The myeloid-specific promoter and the CYBB gene are inserted into a lentiviral vector, and the constructed lentiviral expression vector shows specificity to myeloid tissues and can effectively restore the expression of gp91-phox protein and restore the generation function of ROS, which is of great significance for CGD treatment.

Abstract: A package substrate is provided, in which a first circuit structure is formed on a core board body, and a second circuit structure is formed on the first circuit structure. A second insulating layer of the second circuit structure is made of an ABF material that is different from a material forming a first insulating layer of the first circuit structure, so that a second circuit layer with fine lines/spaces can be formed by the ABF material of the second insulating layer to achieve a purpose of multi-layer fine lines.

Abstract: Method for automatically generating and managing engineering drawings of customized stamping press machine includes following steps. Plural customized parameters are inputted and a stored location is selected through a parameter setting interface of engineering drawings. Assembly file of stamping press machine and plural part files corresponding to plural parts composed of the assembly file are read. Recognition process is performed on each part according to the customized parameters and a customized design rule base of the stamping press machine, thereby determining whether the parts contain plural customized parts that need to regenerate the engineering drawings. CAD software is called to automatically generate plural customized part files corresponding to the customized parts. The CAD software is called to automatically generate plural customized engineering drawings, a customized assembly file and a part list according to the customized parts files.

Abstract: An operation method of a memory controller includes sequentially transmitting a first read command for the first plane and a second read command for the second plane to the nonvolatile memory device, transmitting a first status read command corresponding to the first read command to the nonvolatile memory device, transmitting a first memory access command corresponding to the first read command to the nonvolatile memory device based on first status information, receiving first read data that is output from the nonvolatile memory device, skipping issuing of a status read command corresponding to the second read command and transmitting a second memory access command corresponding to the second read command to the nonvolatile memory device, after receiving the first read data, and receiving second read data that is output from the nonvolatile memory device.

Abstract: The present invention displays an in-the-ear Electroencephalography (EEG) electrode system designed to monitor brain activity in clinical environments, using eartips composed of n-doped silicon or alternative conductive rubber-based materials positioned in the ear canal to accurately detect neurological signals. This electrode system offers wireless and wired configurations, ensuring adaptability to various platforms. This invention addresses the limitations of traditional EEG methodologies by providing a solution for continuous and reliable brain activity monitoring, particularly during intricate surgical procedures. The electrode system displays patient vitals and EEG data in real time, providing medical professionals in diverse clinical settings with comprehensive insights into brain states across a spectrum of frequencies. This system captures Event-Related Potentials (ERPs) and activities in the temporal lobes.

Abstract: Dynamic management method and system for an active state power management (ASPM) mechanism are provided. The method is applicable to a peripheral component interconnect express (PCIe) transmission architecture that includes a host and a PCIe downstream component. The method includes: configuring the PCIe downstream component to perform: determining whether data transmission status between a PCIe upstream component and the PCIe downstream component is in a busy state, a stable idle state or a temporary state; in response to determining that the data transmission status is in the busy state, forcibly disabling the ASPM function; in response to determining that the data transmission state is in the stable idle state, forcibly enabling the ASPM function; and in response to determining that the data transmission state is in the temporary state, determining whether the data transmission state is the busy state, the stable idle state or the temporary state again.

Abstract: The present invention relates to a novel 1,3,4-oxadiazole thiocarbonyl compound having a histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof, pharmaceutically acceptable salts thereof, a use thereof for preparing a medicament, a pharmaceutical composition containing the same, a therapeutic method using the composition, and a preparation method thereof, wherein a novel compound having a selective HDAC6 inhibitory activity is represented by formula I.

Abstract: The present disclosure provides materials and methods related to image processing. In particular, the present disclosure provides methods for enhancing target signal detection using imaging processing analysis that identifies and removes non-specific background signals. The image processing methods of the present disclosure are useful for enhancing target signals in a variety of assays that involve fluorescent detection (e.g., fluorescent in situ hybridization, immunofluorescence).

Abstract: Provided is a method of selecting a two dimension (2D) image for three dimension (3D) reconstruction, the method including: receiving, by an image processing apparatus, 2D images captured at different positions or in different directions; estimating, by the image processing apparatus, a geometric structure of a camera based on feature points detected from the 2D images, and optimizing the geometric structure of the camera using a bundle adjustment (BA) technique; determining, by the image processing apparatus, a priority for each of the 2D images based on a number of tie points used in the BA process; and selecting, by the image processing apparatus, final 2D images to be used for 3D reconstruction based on the priorities of the 2D images.

Abstract: A fixing device includes a docking element having a through hole on the base thereof and two fixing portions at two sides of the base for fixing to a preset first panel, a positioning mechanism, and a rotating mechanism. Turning the rotating element generates a linkage between the rotating sleeve and the positioning element, and forms a rotating and lifting displacement for the positioning sleeve set inside the rotating sleeve to generate a clamp and cause the positioning element to generate a rotating and lifting displacement. Through the positioning portion of the positioning element, it passes through the through hole of the docking element and is held against the base of the docking element to achieve a solid combination of the preset first panel and the preset second panel. It has the purpose of being stable and not easy to loosen and break away, and has the effect of easy operation.

Abstract: A multifunctional pipette includes a pipette module, a heater module and a magnetic module. The pipette module includes one or more pipette heads. The heater module has a first joint part, and the heater module configured to removably connect to the pipette module by coupling the first joint part to at least one of the plurality of pipette heads. The magnetic module has a second joint part, and the magnetic module configured to removably connect to the pipette module by coupling the second joint part to at least one of the plurality of pipette heads. The multifunctional pipette can be further applied in an automatic detection machine.

Abstract: An electronic package is provided, in which an electronic element is disposed on a carrier with a circuit layer, and an encapsulation layer encapsulating the electronic element has an opening exposing the circuit layer, where a metal structure can be contact-bonded on a wall surface of the opening, and a conductive element is formed on the metal structure and electrically connected to the circuit layer. Therefore, no gap is formed between the conductive element and the wall surface of the opening, such that the DC resistance of the conductive element can be reduced.

Abstract: Biocompatible microparticles include an ophthalmically active cyclic lipid component and a biodegradable polymer that is effective, when placed into the subconjunctival space, in facilitating release of the cyclic lipid component into the anterior and posterior segments of an eye for an extended period of time. The cyclic lipid component can be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the cyclic lipid component can be encapsulated by the polymeric component. The present microparticles include oil-in-water emulsified microparticles. The subconjunctivally administered microparticles can be used to treat or to reduce at least one symptom of an ocular condition, such as glaucoma or age related macular degeneration.

Abstract: A power module includes a substrate, chips, supporting pillars, a metal plate and bonding bodies is disclosed. The substrate includes a metallic layer. The chips are on the metallic layer of the substrate, and each of the chips includes a source, a gate, and a drain. The supporting pillars are on the chips. The metal plate is on the supporting pillars and connected with the supporting pillars. The bonding bodies connect the metal plate and the metallic layer.

Abstract: A pressure sensor includes a substrate, a pressure sensing element, a first signal line, a second signal line, an elastomer, and an opposite substrate. The pressure sensing element includes a first resistor and a second resistor connected in series, a third resistor and a fourth resistor connected in series, a first switch component, and a second switch component. The first and the second resistor are connected in parallel to the third and the fourth resistor. The first switch component is electrically connected between the first and the second resistor. The second switch component is electrically connected between the third and the fourth resistor. The first signal line is electrically connected between the first and the fourth resistor. The second signal line is electrically connected between the second and the third resistor. The elastomer includes a cavity. The first resistor to the fourth resistor overlap with the cavity.

Abstract: An interconnect structure includes a first dielectric layer, a first metal layer, a metal via, and a second metal layer. The first dielectric layer is over a substrate. The first metal layer is over the first dielectric layer and has a first segment and a second segment separated from the first segment. The metal via includes a first portion between the first and second segments of the first metal layer, and a second portion above the first metal layer. The second metal layer is over the metal via. From a top view, the second metal layer includes a metal line extending across the first and second segments of the first metal layer. From a cross-sectional view, the first portion of the metal via has opposite sidewalls respectively offset from opposite sidewalls of the second portion of the metal via.

Abstract: The present invention provides methods of making anti-cancer compositions by activating 4-1BBL+ B cells using a CD40 agonist and IFN?. The anti-cancer compositions produced by these methods may be used as an immunotherapy for the treatment of cancer. either alone or in combination with radiation, chemotherapeutics and/or checkpoint blockade.

Abstract: A disinfection cap is described for connection to a medical connector, the disinfection cap includes a housing having a top wall and sidewall forming a cavity, disinfectant or antimicrobial agent and a ball disposed within the cavity. An outer surface of the housing includes a thread sufficient to interlock with a mating feature of a threaded connector, or more specifically a male luer connector. The cap may also include a peelable seal to prevent the disinfectant or the antimicrobial agent from exiting the cavity. The cavity of the cap may also include one or more ribs disposed on the inner surface of the cavity to retain the ball in the cavity, forming a flow channel as the ball is depressed further into the cavity. An exterior sidewall surface of the housing may include a plurality of grip members.

Abstract: A head mounted display device and a strap module thereof are provided. The strap module includes a casing, two straps, two elastic elements, a coupling element and a braking element. The ends of the two straps are respectively connected to opposite sides of a host. The two straps are at least partially overlapped and accommodated in the casing. Two ends of the first elastic element are respectively connected to the casing and the first strap. Two ends of the second elastic element are respectively connected to the casing and the second strap. The elastic recovery force of the two elastic elements is used to drive the two straps to move relative to the casing to increase the overlapping degree of the two straps. The coupling element is rotatably disposed at the casing and simultaneously couples the two straps. The braking element is movably disposed at the casing. When the braking element is in a brake position, the coupling element is braked to fix the overlapping degree of the two straps.