Patent number: 10239873
Abstract: Provided are 7-azaindole or 4,7-diazaindole derivatives as an IKK? (I-kappa-B kinase epsilon) and TBK1 (TANK-binding kinase 1) inhibitor. The 7-azaindole or 4,7-diazaindole derivative effectively inhibits IKK? and TBK1, and thus is useful not only as an anticancer agent for the treatment of various cancers including colorectal cancer, breast cancer, CNS cancer, colon cancer, non-small cell lung cancer, kidney cancer, prostate cancer, ovarian cancer, uterus cancer, stomach cancer, liver cancer, skin cancer, lung cancer, brain cancer, bladder cancer, esophageal cancer, pancreatic cancer, thyroid cancer, head and neck cancer, squamous cell carcinoma, osteosarcoma, B-cell or T-cell lymphoma, acute or chronic leukemia and multiple myeloma, but as a therapeutic agent for chronic inflammation.
Type:
Grant
Filed:
March 24, 2016
Date of Patent:
March 26, 2019
Assignee:
GREEN CROSS CORPORATION
Inventors:
Soongyu Choi, Kwang-Seop Song, Hee Jeong Seo, Sang-ho Ma, Eun-Jung Park, Younggyu Kong, So Ok Park, Kisoo Park, Ickhwan Son, Min Ju Kim, Man-Young Cha, Mi-Soon Kim, Sang Mi Kang, Dong Hyuk Jang, Jangwon Hong
Publication number: 20190088930
Abstract: A prelithiated and surface-stabilized anode active material for use in a lithium battery, comprising a protected anode active material particle comprising a surface-stabilizing layer embracing a core particle, wherein the surface-stabilizing layer comprises a lithium- or sodium-containing species chemically bonded to the core particle and the lithium- or sodium-containing species is selected from Li2CO3, Li2O, Li2C2O4, LiOH, LiX, ROCO2Li, HCOLi, ROLi, (ROCO2Li)2, (CH2OCO2Li)2, Li2S, LixSOy, Li4B, Na4B, Na2CO3, Na2O, Na2C2O4, NaOH, NaiX, ROCO2Na, HCONa, RONa, (ROCO2Na)2, (CH2OCO2Na)2, Na2S, NaxSOy, or a combination thereof, wherein X=F, Cl, I, or Br, R=a hydrocarbon group, 0<x?1, and 1?y?4; wherein the lithium- or sodium-containing species is preferably derived from an electrochemical decomposition reaction and the core particle is prelithiated to contain an amount of lithium from 1% to 100% of the maximum lithium content that can be included in the core particle of anode active material.
Type:
Application
Filed:
September 18, 2017
Publication date:
March 21, 2019
Applicant:
Nanotek Instruments, Inc.
Inventors:
Aruna Zhamu, Bor Z. Jang