Abstract: Provided is a composition for improving a hair or scalp condition including hydrangenol as an active ingredient. The composition including hydrangenol as an active ingredient inhibits the activity of 5?-reductase, which is a hair loss mediating factor, promotes growth of dermal papilla cells, alleviates roughness of hair cuticles, and increases the tensile strength of hair. Accordingly, the composition can be effectively used to improve the condition of hair or scalp.

Abstract: Provided is a method for preventing or improving UV-induced skin damage of a subject in need thereof, which comprises administering to the subject an effective amount of a composition containing hydrangenol derived from the extract of Hydrangea serrata as an active ingredient. The composition containing hydrangenol derived from the extract of Hydrangea serrata is able to increase secretion of hyaluronic acid and procollagen type-1 and inhibit secretion of MMP-1 in skin cells, and therefore effective in preventing or improving UV-induced damage of skin cells. Accordingly, the hydrangenol-containing composition is usefully available as a quasi-drug, drug, food, or cosmetic composition.

Abstract: Disclosed in the present invention are: a pharmaceutical composition for preventing or treating fibrotic diseases, comprising hyaluronan and proteoglycan link protein 1 (HAPLN1) or a gene encoding same as an active ingredient; and a method for preventing or treating fibrotic diseases using the composition. According to the present invention, fibrosis of cells or tissues is prevented and inhibited such that the occurrence or progression of various kinds of diseases caused by fibrosis is fundamentally suppressed, and thus the diseases can be prevented or treated.

Abstract: A display device includes a display panel including a display area, a pad area spaced apart from the display area, and a bending area adjacent to the display area in a first direction, disposed between the display area and the pad area, and bent from the display area, a window member disposed on a first surface of the display panel, and a spacer disposed on a second surface of the display panel opposite to the first surface and overlapping the display area and the pad area. A first opening pattern is defined at an end portion of the spacer.

Abstract: The present invention relates to a composition for repairing vascular degeneration and vascular injuries and preventing or treating vascular diseases, containing hyaluronan and proteoglycan link protein 1 (HAPLN1) as an active ingredient. More specifically, provided is a pharmaceutical composition and a health functional food composition for preventing or treating vascular diseases, containing HAPLN1 as an active ingredient. HAPLN1 inhibits and alleviates, in blood vessel walls, damage to the elastin fiber layer and loss of transgelin, and effectively inhibits the phosphorylation of NF-?B or focal adhesion kinase (FAK) in vascular smooth muscle cells (VSMCs), and thus can be used for preventing, alleviating or treating vascular injuries and various diseases caused by aging or a high-fat diet.

Abstract: An apparatus and a method for a data learning server is provided. The apparatus of the disclosure includes a communicator configured to communicate with an external device, at least one processor configured to acquire a set temperature set in an air conditioner and a current temperature of the air conditioner at the time of setting the temperature via the communicator, and a generate or renew a learning model using the set temperature and the current temperature, and a storage configured to store the generated or renewed learning model to provide a recommended temperature to be set in the air conditioner as a result of generating or renewing the learning model. For example, the data learning server of the disclosure may generate a learned learning model to provide a recommended temperature using a neural network algorithm, a deep learning algorithm, a linear regression algorithm, or the like as an artificial intelligence algorithm.

Abstract: Provided are a medium composition for culturing animal cells for producing a recombinant extracellular matrix protein, a method of producing the recombinant extracellular matrix protein with high purity, and a method of assaying a monomer of the recombinant extracellular matrix protein.

Abstract: A display device includes a substrate comprising a plurality of pixel areas and a non-pixel area surrounding each of the plurality of pixel areas. The non-pixel area includes a plurality of first areas and a second area surrounding the plurality of first areas. A functional layer is disposed on the substrate and includes a plurality of first holes defined through the functional layer and overlapping the plurality of first areas. An element layer is disposed on the functional layer. A pixel definition layer is disposed on the element layer and overlaps the non-pixel area. The pixel definition layer includes pixel openings defined therethrough. The pixel openings overlap the plurality of pixel areas. A plurality of light emitting elements is disposed on the element layer and is disposed in the pixel openings.

Abstract: The present disclosure relates to a composition for the prevention, improvement, or treatment of cartilage-related diseases or symptoms, the composition including hyaluronan and proteoglycan link protein 1 (HAPLN1) as an active ingredient. In detail, the present disclosure provides a composition for regenerating cartilage, a composition for the prevention, improvement, or treatment of osteoarthritis, or a composition for regenerating growth plate cartilage, each composition including HAPLN1 as an active ingredient.

Abstract: The present disclosure relates to a copper alloy tube for a heat exchanger having excellent breaking strength and a method of manufacturing the same, and more particularly, to a Cu alloy tube having excellent breaking strength and thermal conductivity and suitable for use in a heat exchanger, and a method of manufacturing the same.

Abstract: According to one aspect of the invention, a flexible pad for a display device lamination process includes: a generally straight area having an upper surface defining substantially the same height along a first direction and a generally convex shape along a second direction generally perpendicular to the first direction; a first inclined area having a first upper surface inclined along the first direction at a first inclination angle and being generally flat along the second direction; and a second inclined area disposed between the first inclined area and the generally straight area, wherein the second inclined area has a second upper surface inclined along the first direction at a second inclination angle smaller than the first inclination angle.

Abstract: Provided are a recombinant hyaluronan and proteoglycan link protein 1 (HAPLN1), and a composition for preventing or treating pulmonary diseases, the composition comprising at least one selected from the group consisting of HAPLN1 (hyaluronan and proteoglycan link protein 1) protein, a gene coding for the HAPLN1 protein, and an effective agent for promoting the expression or activating the functions of HAPLN1 protein or gene as an active ingredient. The recombinant HAPLN1 according to the present disclosure may have superior effects of improving alveolar damage caused by aging or elastin reduction, and thus may effectively prevent or treat pulmonary diseases, such as chronic bronchitis, asthma, emphysema, and chronic obstructive pulmonary disease.

Abstract: Provided are a medium composition for culturing animal cells for producing a recombinant extracellular matrix protein, a method of producing the recombinant extracellular matrix protein with high purity, and a method of assaying a monomer of the recombinant extracellular matrix protein.

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating hair loss, comprising hyaluronan and proteoglycan link protein 1 (HAPLN1) as an active ingredient. When administered, the HAPLN1 protein of the present invention grows hair by promoting the proliferation of hair germinal matrix cells through a Ras-ERK1/2 signaling pathway activated by a TGF-? protein.

Abstract: A compound having one of formula (1), formula (2), formula (3) and formula (4) or a pharmacologically acceptable salt thereof.

Abstract: The present disclosure relates to a copper alloy tube for a heat exchanger having excellent breaking strength and a method of manufacturing the same, and more particularly, to a Cu alloy tube having excellent breaking strength and thermal conductivity and suitable for use in a heat exchanger, and a method of manufacturing the same.

Abstract: An apparatus and a method for a data learning server is provided. The apparatus of the disclosure includes a communicator configured to communicate with an external device, at least one processor configured to acquire a set temperature set in an air conditioner and a current temperature of the air conditioner at the time of setting the temperature via the communicator, and a generate or renew a learning model using the set temperature and the current temperature, and a storage configured to store the generated or renewed learning model to provide a recommended temperature to be set in the air conditioner as a result of generating or renewing the learning model. For example, the data learning server of the disclosure may generate a learned learning model to provide a recommended temperature using a neural network algorithm, a deep learning algorithm, a linear regression algorithm, or the like as an artificial intelligence algorithm.

Abstract: Provided is a method of regenerating cartilage tissues by treatment with hyaluronan and proteoglycan link protein 1 (HAPLN1), and a composition for regenerating cartilage, the composition including HAPLN1 as an active ingredient. According to the present disclosure, the HAPLN1 protein may have cartilage formation-stimulating ability and articular cartilage regeneration ability, may increase an expression level of TGF-? receptor I of chondrocytes to increase a component ratio of cells having cartilage formation ability, and to induce regeneration of cartilage tissues. Accordingly, the HAPLN1 protein of the present disclosure, which is a novel composition regulating TGF-? signaling, may be usefully applied as a pharmaceutical composition for regenerating cartilage, a health food composition for regenerating cartilage, or a reagent composition for regenerating cartilage.

Abstract: The present disclosure relates to HAPLN1 protein of an aged individual. The HAPLN1 protein exhibits reduced expression with aging, and when administered, its effect in alleviating and reversing skin aging including wrinkles is excellent. Therefore, by exploiting the difference in expression, provided are a biomarker composition for measuring skin aging, capable of diagnosing skin aging; a kit; and a method of screening for skin aging alleviating agents, comprising detecting the expression level of HAPLN1 protein or HAPLN1 gene. In addition, provided are a pharmaceutical composition, cosmetic composition, or health functional food for preventing or alleviating skin aging, and a cosmetic composition or health functional food for alleviating wrinkles, each containing any one or more selected from the group consisting of HAPLN1 protein, a gene encoding the same, and an effective agent for promoting the expression or activating the functions of HAPLN1 protein or gene.

Abstract: An apparatus and a method for a data learning server is provided. The apparatus of the disclosure includes a communicator configured to communicate with an external device, at least one processor configured to acquire a set temperature set in an air conditioner and a current temperature of the air conditioner at the time of setting the temperature via the communicator, and a generate or renew a learning model using the set temperature and the current temperature, and a storage configured to store the generated or renewed learning model to provide a recommended temperature to be set in the air conditioner as a result of generating or renewing the learning model. For example, the data learning server of the disclosure may generate a learned learning model to provide a recommended temperature using a neural network algorithm, a deep learning algorithm, a linear regression algorithm, or the like as an artificial intelligence algorithm.