Abstract: An integrated heat exchanger in which a flow path, in which a first heat exchange medium flows, and a flow path, in which a second heat exchange medium flues, are separated by a baffle, and includes a support surface having a slope of which the height lowers toward the outside, and formed at a header portion coming in contact with a gasket baffle sealing part, and the gasket baffle sealing part formed in a shape corresponding to the support surface of a header such that the deformation of a gasket is prevented during coupling; and problems in which the gasket of a coupling part, at which the baffle is positioned, is non-uniformly compressed or the gasket is broken or separated from a designated position by means of force of the other direction is prevented.

Abstract: Provided is a recombinant microorganism for producing carnosine, histidine and beta-alanine and a method for producing carnosine, histidine and beta-alanine by using same and, more particularly, to: a recombinant microorganism for high production of carnosine, histidine and beta-alanine produced through the redesign of metabolic pathways; a method for producing same; and a method for producing carnosine, histidine and beta-alanine by using same.

Abstract: The present invention relates to a heat exchanger for a motor vehicle provided on the front surface of an engine room of the vehicle, and, more particularly, to a heat exchanger for a motor vehicle including a sealing member provided on the circumference of the heat exchanger in order to prevent driving-induced wind from leaking to the outside of the heat exchanger without passing through the heat exchanger.

Abstract: The present invention relates to a cooling module for a vehicle, and more particularly, to a cooling module for a vehicle including a condenser, a first radiator through which coolant for an engine flow, a second radiator through which coolant for electrical components flows, and an intercooler, and capable of evenly distributing air resistance of the front surface of the first radiator to secure an overall balance of an air volume distribution by disposing the condenser, the second radiator, and the first radiator in a flow direction of air or disposing the second radiator, the condenser, and the first radiator in this order, and disposing the intercooler on lower sides of the condenser and the second radiator, and capable of minimizing a gap of each heat exchange period by disposing the condenser C and the first radiator R to be in closely contact with the second radiator L.

Abstract: An antenna apparatus includes a dielectric layer; a patch antenna pattern disposed on an upper surface of the dielectric layer and including an upper surface having a polygonal shape, a plurality of feed vias respectively disposed to penetrate the dielectric layer by at least a portion of a thickness of the dielectric layer, respectively disposed to be biased toward a first side and a second side, different from each other, from a center of the polygonal shape of the patch antenna pattern, and respectively disposed to be spaced apart from the patch antenna pattern, and a plurality of feed patterns respectively electrically connected to an upper end of a corresponding feed via, among the plurality of feed vias, respectively disposed to be spaced apart from the patch antenna pattern, and configured to provide a feed path to the patch antenna pattern, wherein the polygonal shape of the patch antenna pattern has a structure in which the first side and a third side between the first and second sides form an obtuse

Abstract: The present disclosure relates to a water supply module integrated with a reservoir tank, the module comprising: a reservoir tank in which a hollow portion is formed to accommodate cooling water therein, and which includes a first mounting part provided on one side thereof and a second mounting part provided on the other side thereof; a first component mounted on the first mounting part; and a second component mounted on the second mounting part, wherein the first component and the second component pass through the reservoir tank so as to be connected such that cooling water paths are directly connected to each other without bypassing the reservoir tank, and thus a cooling circuit of a vehicle cooling system can be simplified and formed to be integrated.

Abstract: The present invention relates to a feedback device and a method of providing thermal feedback using the same. A method for calibration of an intensity of a thermal feedback of a feedback device may comprise: outputting the thermal feedback in order from a weak intensity to a strong intensity among a plurality of intensities of the thermal feedback; obtaining a first user input; setting an intensity of the thermal feedback outputted at the time of the obtaining the first user input to a lowest intensity of the thermal feedback; obtaining a second user input; setting an intensity of the thermal feedback outputted at the time of the obtaining the second user input to a highest intensity of the thermal feedback; setting at least one intermediate intensity; and outputting the thermal feedback by using the lowest intensity, the highest intensity and the at least one intermediate intensity.

Abstract: An antenna apparatus includes a dielectric layer; a patch antenna pattern disposed on an upper surface of the dielectric layer and including an upper surface having a polygonal shape, a plurality of feed vias respectively disposed to penetrate the dielectric layer by at least a portion of a thickness of the dielectric layer, respectively disposed to be biased toward a first side and a second side, different from each other, from a center of the polygonal shape of the patch antenna pattern, and respectively disposed to be spaced apart from the patch antenna pattern, and a plurality of feed patterns respectively electrically connected to an upper end of a corresponding feed via, among the plurality of feed vias, respectively disposed to be spaced apart from the patch antenna pattern, and configured to provide a feed path to the patch antenna pattern, wherein the polygonal shape of the patch antenna pattern has a structure in which the first side and a third side between the first and second sides form an obtuse

Abstract: An antenna apparatus includes a ground plane, a patch antenna pattern disposed on an upper surface of the ground plane, a feed via penetrating the ground plane and spaced apart from the patch antenna pattern, and a coiled feed pattern electrically connected to an upper end of the feed via, spaced apart from the patch antenna pattern, and configured to provide a feed path to the patch antenna pattern, wherein at least a portion of the coiled feed pattern is coiled, wherein the patch antenna pattern includes an aperture portion corresponding to the coiled feed pattern.

Abstract: The present invention relates to a feedback device and a method of providing thermal feedback using the same. A method for calibration of an intensity of a thermal feedback of a feedback device may comprise: outputting the thermal feedback in order from a weak intensity to a strong intensity among a plurality of intensities of the thermal feedback; obtaining a first user input; setting an intensity of the thermal feedback outputted at the time of the obtaining the first user input to a lowest intensity of the thermal feedback; obtaining a second user input; setting an intensity of the thermal feedback outputted at the time of the obtaining the second user input to a highest intensity of the thermal feedback; setting at least one intermediate intensity; and outputting the thermal feedback by using the lowest intensity, the highest intensity and the at least one intermediate intensity.

Abstract: The present disclosure relates to an integrated housing capable of integrally connecting several components of a water supply module, and the water supply module including same. According to the present disclosure, hoses or pipes are removed or a pipe length is reduced through the integration of components constituting a cooling system, and thus a reduction in size and weight can be promoted.

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating pancreatic cancer associated with a RON mutation and a method using the same. The pharmaceutical composition for preventing or treating cancer according to the present invention may be applied to patients with pancreatic cancer in which a RON mutation is present. In particular, the present invention may be usefully used as a precision medicine for patients with pancreatic cancer which has resistance to cetuximab used in conventional anticancer therapy and has the RON?155, RON?160, or RON?165 mutation.

Abstract: The present invention relates to: a biomarker composition for predicting the prognosis of brain disease caused by microplastic exposure; and a use thereof. More particularly, it was confirmed that polyethylene microspheres (PS) in a mouse animal model orally administered with the PS penetrate brain tissue to change the level of metabolites inside the brain tissue and the diversity of intestinal microorganisms, thereby causing brain disease, and thus the present invention is intended to provide a biomarker composition for predicting the prognosis of brain disease caused by microplastic exposure, and a method for predicting the prognosis of brain disease using same.

Abstract: The present invention relates to a heat exchanger comprising: a header tank having a plurality of flow paths in which a heat exchange medium flows; multiple rows of tubes connected to the header tank; and heat radiation fins interposed between the tubes, wherein the tubes include a heat exchange part coupled to the heat radiation fins and a coupling part that is formed on a longitudinal end of the heat exchange part and coupled to the header tank, the width of the coupling part is formed to be less than the width of the heat exchange part so that the overall package size of the heat exchanger may be reduced, thus enabling a compact configuration, and the space between neighboring rows of the tubes may be reduced, thus making it possible to reduce the material of the heat radiation fins.

Abstract: A pharmaceutical composition that is useful preventing or treating cancer with a KRAS mutation and activated RON is disclosed. The pharmaceutical composition may be utilized as an anticancer drug that exhibits an excellent cell death-inducing ability on cancer cells with KRAS G13 mutation or KRAS G12 mutation and a RON mutation or tyrosine-phosphorylated RON (pTyr-RON).

Abstract: A method for providing a thermal feedback, includes executing a virtual reality application providing a virtual space that includes a virtual area to which an area temperature attribute is assigned, and a virtual object to which an object temperature attributed is assigned. An area event that reflects that a player character enters the virtual area is detected. A feedback device is controlled to output thermal feedback associated to the area temperature attribute when the area event is detected, the feedback device outputting the thermal feedback using a thermoelectric element performing a thermoelectric operation. An object event reflecting the player character is influenced by the virtual object is detected. The feedback device is controlled to override the thermal feedback associated to the area temperature attribute and output thermal feedback associated to the object temperature when the object is detected while the player character is in the virtual area.

Abstract: The present invention relates to a heat exchanger for a motor vehicle provided on the front surface of an engine room of the vehicle, and, more particularly, to a heat exchanger for a motor vehicle including a sealing member provided on the circumference of the heat exchanger in order to prevent driving-induced wind from leaking to the outside of the heat exchanger without passing through the heat exchanger.

Abstract: An oxo-pyridine fusion ring compound of chemical formula 1 or a pharmaceutically acceptable salt thereof effectively inhibits the activity of RON and can not only effectively suppress the cell growth of cancer cell lines in which RON is activated, but also can effectively kill the cancer cell lines.

Abstract: The present invention relates to a feedback device and a method of providing thermal feedback using the same. A method for calibration of an intensity of a thermal feedback of a feedback device may comprise: outputting the thermal feedback in order from a weak intensity to a strong intensity among a plurality of intensities of the thermal feedback; obtaining a first user input; setting an intensity of the thermal feedback outputted at the time of the obtaining the first user input to a lowest intensity of the thermal feedback; obtaining a second user input; setting an intensity of the thermal feedback outputted at the time of the obtaining the second user input to a highest intensity of the thermal feedback; setting at least one intermediate intensity; and outputting the thermal feedback by using the lowest intensity, the highest intensity and the at least one intermediate intensity.

Abstract: A method for providing a thermal feedback, includes executing a virtual reality application providing a virtual space that includes a virtual area to which an area temperature attribute is assigned, and a virtual object to which an object temperature attributed is assigned. An area event that reflects that a player character enters the virtual area is detected. A feedback device is controlled to output thermal feedback associated to the area temperature attribute when the area event is detected, the feedback device outputting the thermal feedback using a thermoelectric element performing a thermoelectric operation. An object event reflecting the player character is influenced by the virtual object is detected. The feedback device is controlled to override the thermal feedback associated to the area temperature attribute and output thermal feedback associated to the object temperature when the object is detected while the player character is in the virtual area.