Abstract: The present invention relates to a pyrrolobenzodiazepine dimer prodrug and a ligand-linker conjugate compound thereof, a composition containing these, and therapeutic use thereof particularly as an anticancer drug. The stability of the compounds themselves and the stability thereof in plasma are excellent and the compounds are advantageous in terms of manifestation of toxicity, and thus the compounds are industrially useful in that it is possible to target proliferative diseases such as cancer, to perform a specific treatment, to maximize the drug efficacy, and to minimize the occurrence of side effects.

Abstract: The present disclosure relates to antibody-drug conjugates (ADCs) wherein one or more active agents are conjugated to an anti-CD19 antibody through a linker. The linker may comprise a unit that covalently links active agents to the antibody. The disclosure further relates to monoclonal antibodies and antigen binding fragments, variants, multimeric versions, or bispecifics thereof that specifically bind CD19, as well as methods of making and using these anti-CD19 antibodies and antigen-binding fragments thereof in a variety of therapeutic, diagnostic and prophylactic indications.

Abstract: A display device includes a display panel including a display area and a pad area. The display panel includes a base substrate, a pixel, a pad group, an alignment mark, and a protective layer. The pad group includes a plurality of pads arranged in a first direction. The alignment mark is spaced apart from the pad group in the first direction. The protective layer covers the pads and the alignment mark and a plurality of openings respectively exposing upper surfaces of the pads is defined in the protective layer. Each of the pads includes at least one pad pattern, and the alignment mark is disposed in a same layer as a pad pattern spaced farthest from the base substrate among the at least one pad pattern.

Abstract: A display apparatus includes a flexible circuit board including a plurality of first substrate pads and a plurality of second substrate pads, a main circuit board connected to the flexible circuit board, and a display panel including a plurality of first display pads and a plurality of second display pads, where the plurality of first display pads is connected to the main circuit board through the flexible circuit board and each of the plurality of first display pads at least partially overlaps corresponding substrate pad of the plurality of first substrate pads, respectively, and each of the plurality of second display pads at least partially overlaps corresponding substrate pad of the plurality of second substrate pads, respectively.

Abstract: A chip on film for a display device, the chip on film includes: a base substrate; a lead wire disposed on the base substrate; and a driving chip connected to the lead wire, wherein the lead wire includes: a first lead part having a first thickness; and a second lead part disposed between the first lead part and the driving chip and having a second thickness greater than the first thickness, the second lead part being connected to the driving chip. The first lead part and the second lead part include a same material.

Abstract: The present invention provide a filler metal for TIG welding capable of stable welding, of which heat flux feeding area is wider than conventional wire filler metal and heat input per unit length is increased. The filler metal for TIG welding which is continuously supplied on a base metal to be melted by an arc after forming the arc between the base metal and an electrode over the base metal and supplying shield gas around the arc, wherein the cross-section of the filler metal has curved shape of which surface facing the electrode is concavely curved to the electrode.

Abstract: The present disclosure relates to pyrrolobenzodiazepine dimer prodrugs and ligand-linker conjugates thereof. The present disclosure also relates to compositions and uses of said prodrugs and conjugates.

Abstract: The present invention relates to a high temperature-superconducting wire having a superconducting layer laminated thereon and a method of manufacturing the same. The method includes: preparing a pair of superconducting wires each of which includes a metal substrate, a buffer layer, a superconducting layer, and a protective layer; laminating the pair of superconducting wires to allow respective protective layers to face each other; performing thermal treatment to the laminated superconducting wires to join the protective layers together; separating the metal substrate and the buffer layer from the superconducting layer on one side; and forming a protective layer on an upper part of the superconducting layer having a surface exposed.

Abstract: A display device may include a display panel including an active area displaying an image and a peripheral area surrounding the active area, pad parts disposed on a side surface of the display panel, a light blocking layer disposed on a portion of the peripheral area adjacent to the side surface of the display panel, and circuit units electrically connected to the pad parts.

Abstract: A bonding apparatus includes: an anisotropic conductive film (“ACF”) attachment unit which attaches a first ACF and a second ACF onto a display panel assembly; a compression unit which compresses a first chip-on-film (“COF”) on the first ACF and compresses a second COF on the second ACF; and a buffer unit which rotates the display panel assembly, on which the first ACF and the second COF are compressed, on a plane.

Abstract: The present invention relates to novel compounds as autotoxin inhibitors for treatment and prophylaxis of conditions or a disorder caused by autotaxin activation or increased concentration of lysophosphatidic acid, and also a pharmaceutical composition containing the same. The novel compounds of the present invention are autotoxin inhibitors, and by inhibiting the production of lysophosphatidic acid, they are useful for treatment or prophylaxis of cardiovascular disorder, cancer, metabolic disorder, kidney disorder, liver disorder, inflammatory disorder, nervous system disorder, respiratory system disorder, fibrotic disease, ocular disorder, cholestatic and other forms of chronic pruritus, or acute or chronic organ transplant rejection.

Abstract: A display apparatus, includes: a flexible circuit board including a first board pad and a second board pad, which are spaced apart from each other in a first direction and extend in a second direction intersecting the first direction; a main circuit board coupled to the flexible circuit board; and a display panel coupled to the flexible circuit board, the display panel including a first display pad overlapped with the first board pad and a second display pad overlapped with the second board pad, wherein the first board pad includes a first, second, and third portions, and the second board pad includes a first, second, and third portions.

Abstract: The present invention relates to a metal ion-start DNA polymerase switch, a composition for isothermal polymerase amplification containing the same, and an isothermal amplification method using the metal ion-start DNA polymerase switch. The metal ion-start DNA polymerase switch according to the present invention may comprise: a binding module composed of TQ30 aptamer; a locking or unlocking module; and a catalytic module connecting between the binding module and the locking or unlocking module and composed of DNAzyme.

Abstract: An apparatus for dispensing a consumable to a user includes a body, a bar movable relative to the body, an air inlet, a flow generator to receive inlet air from the air inlet and to generate an airflow, a consumable dispensing unit to receive a quantity of a consumable, and a nozzle operatively connected to the consumable dispensing unit to receive the consumable from the consumable dispensing unit. The nozzle provided within a flow path of the airflow from the flow generator such that the consumable is drawn from the consumable dispensing unit, mixed with the airflow, and expelled from the nozzle.

Abstract: Provided is a method of fabricating a core-shell structured nanowire on a tip of an optical fiber, on a substrate, or any position on other target objects, and a nanowire fabricated by the method. The nanowire fabricated by the method of the present invention may be used for a drug delivery system, a sensor, an optical waveguide, and the like.

Abstract: A drying apparatus includes a body, an air inlet, a flow generator to receive inlet air from the air inlet and generate an airflow, an air outlet at the body for exhausting the airflow from the flow generator, the air outlet extending along a vertical height of the body, and an outlet airflow steering mechanism operable to control a lateral extent of the airflow from the air outlet. A controller is configured to operate the outlet airflow steering mechanism to control the lateral extents of the airflow from the air outlet.

Abstract: A drying arrangement includes a primary drying module having: a body, a bar movable relative to the body, the bar having an air outlet for exhausting an airflow in a first airflow direction; and a secondary drying module having a housing, the housing having an air outlet for exhausting an airflow in a second airflow direction; wherein the first airflow direction and the second airflow direction differ from one another.

Abstract: A display device may include a display panel including an active area displaying an image and a peripheral area surrounding the active area, pad parts disposed on a side surface of the display panel, a light blocking layer disposed on a portion of the peripheral area adjacent to the side surface of the display panel, and circuit units electrically connected to the pad parts.

Abstract: A multilayer ceramic electronic component includes a ceramic body including first and second internal electrodes disposed to face each other and a dielectric layer interposed therebetween. When an average thickness of the dielectric layer is denoted as ‘td,’ an average thickness of the first and second internal electrodes is denoted as ‘te,’ and a standard deviation of thicknesses of an internal electrode, measured at a plurality of points in a predetermined region of the internal electrode, is denoted as ‘?te,’ a ratio of the standard deviation of thicknesses of the internal electrode to the average thickness of the dielectric layer, which is denoted as ‘?te/td,’ satisfies 0.12??te/td?0.21.

Abstract: A drying apparatus includes a body, a bar movable relative to the body; an air inlet, a flow generator to receive inlet air from the air inlet and generate an airflow, and a bar air outlet at the bar for exhausting the airflow from the flow generator. A bar orientation mechanism is operable to control an orientation of the bar.