Abstract: Provided are fusion proteins and related molecules useful for conducting base editing with reduced or no off-target mutations. The fusion proteins may include a first fragment comprising a nucleobase deaminase or a catalytic domain thereof, a second fragment comprising a nucleobase deaminase inhibitory domain, and a protease cleavage site between the first fragment and the second fragment. Also provided are improved prime editing systems, including prime editing guide RNA with improved stability.

Abstract: A semiconductor device including: an active region; first, second and third metal-to-drain/source (MD) contact structures which extend in a first direction and correspondingly overlap the active region; a via-to-via (V2V) rail which extends in a second direction perpendicular to the first direction, and overlaps the first, second and third MD contact structures; a first conductive segment which overlaps the V2V rail, is in a first metallization layer, and, relative to the second direction, overlaps each of the first, second and third MD contact structures; and a first via-to-MD (VD) structure between the first MD contact structure and the first conductive segment, the first VD structure electrically coupling the first conductive segment, the V2V rail and the first MD contact structure; wherein at least one of the second or third MD contact structures is electrically decoupled from the V2V rail.

Abstract: A method for storing an evidence collection process video segment includes: obtaining a clip-for-storage request initiated by a user, the clip-for-storage request specifying a to-be-clipped evidence collection process video and clipping range information, and the evidence collection process video being obtained by the evidence collection service device by recording evidence collection processes for at least two web pages; determining whether the evidence collection process video is stored in a blockchain, and clipping a video segment from the evidence collection process video based on the clipping range information in response to determining that the evidence collection process video is stored in the blockchain, the video segment recording an evidence collection process corresponding to any one of the at least two web pages; and committing the video segment to the blockchain for storage.

Abstract: Provided herein are tetravalent antigen binding complexes having agonist activity for a cell surface receptor. In some embodiments, the complexes comprise binding specificities for multiple epitopes of the same cell surface receptor. Further provided herein are nucleic acids, vectors, host cells, pharmaceutical compositions, and methods of production related thereto.

Abstract: A fabrication method of an electronic device bonding structure includes the following steps. A first electronic component including a first conductive bonding portion is provided. A second electronic component including a second conductive bonding portion is provided. A first organic polymer layer is formed on the first conductive bonding portion. A second organic polymer layer is formed on the second conductive bonding portion. Bonding is performed on the first electronic component and the second electronic component through the first conductive bonding portion and the second conductive bonding portion, such that the first electronic component and the second electronic component are electrically connected. The first organic polymer layer and the second organic polymer layer diffuse into the first conductive bonding portion and the second conductive bonding portion after the bonding. An electronic device bonding structure is also provided.

Abstract: An implantable spacer for placement between adjacent spinous processes in a spinal motion segment is provided. The spacer includes a body defining a longitudinal axis and passageway. A first arm and a second arm are connected to the body. Each arm has a pair of extensions and a saddle defining a U-shaped configuration for seating a spinous process therein. Each arm has a proximal earning surface and is capable of rotation with respect to the body. An actuator assembly is disposed inside the passageway and connected to the body. When advanced, a threaded shaft of the actuator assembly contacts the earning surfaces of arms to rotate them from an undeployed configuration to a deployed configuration. In the deployed configuration, the distracted adjacent spinous processes are seated in the U-shaped portion of the arms.

Abstract: A method of controlling a fan speed for a battery unit includes determining power discharge and a current temperature of a battery unit and obtaining a relationship between fan speed for the battery unit and temperature of the battery unit based on the power discharge and the current temperature of the battery unit. The method further includes identifying a minimum fan speed based on the relationship between fan speed and temperature and a maximum operating temperature of the battery unit and controlling the fan by setting the speed of the fan to the minimum fan speed.

Abstract: An electrode assembly and a lithium-ion battery are described. The electrode assembly includes a positive electrode plate, a separator, and a negative electrode plate, where the negative electrode plate includes a negative electrode current collector and a negative electrode active substance layer, the negative electrode plate further includes a lithium metal layer, the lithium metal layer is formed by a plurality of regular or irregular strip-shaped lithium-rich regions, and the plurality of lithium-rich regions present a discontinuous pattern of spaced distribution in a length direction of the negative electrode plate. The electrode assembly further satisfies that: negative electrode capacity per unit area/positive electrode capacity per unit area=1.2 to 2.1 and negative electrode capacity per unit area/(positive electrode capacity per unit area+capacity of the lithium metal layer on the surface of the negative electrode active substance layer per unit area×80%)?1.10.

Abstract: A water-harvesting system can operate with a material that can take up and release water with minimum energy requirements and powered by low-grade energy sources, such as sunlight, in order to potentially allow its deployment into households, especially those located in sunny regions. A water-harvesting method and system can include multiple layers of adsorptive material.

Abstract: The exemplary embodiments relate to converting standard dynamic range (SDR) content to high dynamic range (HDR) content. An SDR image may be decomposed into a base layer of the SDR image that includes low frequency information from the SDR image and a detail layer of the SDR image that includes high frequency information from the SDR image. A base layer of an HDR image may be generated using the base layer of the SDR image and a detail layer of the HDR image may be generated using the detail layer of the SDR image. An HDR image is then generated using the base layer of the HDR image and the detail layer of the HDR image.

Abstract: The present disclosure relates to the field of miRNA and exosomes, in particular to the use of miRNA in preparation of drugs for preventing and treating osteoarthritis, and the use of miRNA exosomes with high expression. The present disclosure provides the use of miR-155-5p in preparation of drugs for preventing and/or treating osteoarthritis. The nucleotide sequence of miR-155-5p is set forth in SEQ ID NO.:1. Use of the present disclosure can improve miR-155-5p expression by targeting miR-155-5p to Runx2, promote chondrocyte growth proliferation, migration, and extracellular matrix secretion and inhibition of cell apoptosis, thus producing the effect of preventing or treating osteoarthritis.

Abstract: A connector visual inspection apparatus comprises a rotatable clamp for clamping a connector to be inspected. A first camera of the apparatus is arranged on one side of the clamp for capturing an end face image of the clamped connector along an axial direction of the connector. A computing device calculates an angular difference between an initial loading orientation and a predetermined orientation of the clamped connector according to the captured end face image. A drive device rotates the clamp around an axis that coincides with a central axis of the clamped connector by the calculated angular difference and into the predetermined orientation.

Abstract: A pacemaker has a housing and a therapy delivery circuit enclosed by the housing for generating pacing pulses for delivery to a patient's heart. An electrically insulative distal member is coupled directly to the housing and at least one non-tissue piercing cathode electrode is coupled directly to the insulative distal member. A tissue piercing electrode extends away from the housing.

Abstract: The invention discloses a speech processing method and system in a cochlear implant. The method includes: obtaining a sound signal, and converting the sound signal into a digital signal; decomposing the digital signal using a mode decomposition method, obtaining a plurality of intrinsic mode functions, and converting the plurality of intrinsic mode functions into instantaneous frequencies and instantaneous amplitudes or instantaneous energy intensities; sorting the instantaneous frequencies to corresponding the preset electrode frequency bands of the electrodes in the cochlear implant; selecting N most energetic components from the corresponding frequency bands of the electrodes, and generating corresponding electrode stimulation signals according to the selected components. The present invention analyzes sound and composes the final electrode signals all in the time domain based on Hilbert-Huang transform; it is not limited by the principle of uncertainty, and there is no noise generated by harmonics.

Abstract: Exemplary methods of semiconductor processing may include flowing a silicon-containing precursor, a nitrogen-containing precursor, and diatomic hydrogen into a processing region of a semiconductor processing chamber. A substrate may be housed within the processing region of the semiconductor processing chamber. The methods may also include forming a plasma of the silicon-containing precursor, the nitrogen-containing precursor, and the diatomic hydrogen. The plasma may be formed at a frequency above 15 MHz. The methods may also include depositing a silicon nitride material on the substrate.

Abstract: A display device includes a diffractive optical element and a tunable light source operable in different states including a first state and a second state. The tunable light source provides first light having a first wavelength while the tunable light source is in the first state and second light having a second wavelength, distinct from the first wavelength, while the tunable light source is in the second state. The first wavelength and the second wavelength correspond to a first color band. The diffractive optical element is positioned to receive and redirect the first light and receive and redirect the second light. The diffractive optical element has a first focal length for the first light and a second focal length, distinct from the first focal length, for the second light.

Abstract: Disclosed are a method and apparatus for controlling the power consumption of a terminal, and a storage medium. The method comprises: obtaining a temperature of the terminal; and in response to the temperature being greater than a first temperature threshold, controlling the terminal to switch from a dual-connection mode to a single-connection mode based on a power consumption adjustment strategy; wherein the terminal supports the dual-connection mode; the terminal is configured to communicate with a first base station and to communicate with a second base station in the dual connection mode; the first base station is a primary base station, and the second base station is a secondary base station.

Abstract: Provided is a barrier film, comprising: a base layer; and an inorganic layer including a first region and a second region, which have different elemental contents (atomic %) of Si, N, and O from each other as measured by XPS, and having a compactness expressed through an etching rate of 0.17 nm/s or less in the thickness direction for an Ar ion etching condition to etch Ta2O5 at a rate of 0.09 nm/s, wherein the second region has a higher elemental content of N than that of the first region, the first region has a thickness of 50 nm or more, and the ratio (d1/d2) of the thickness (d1) of the first region to the thickness (d2) of the second region is 2 or less, the barrier film having excellent barrier properties and optical properties. The barrier film can be used for electronic products sensitive to moisture or the like.

Abstract: Provided are a device synchronization method and apparatus, a device, and a storage medium. The device synchronization method includes: in response to determining that a second device does not receive a first data packet, determining a target time cycle for sending data packets by the second device based on a preset cycle adjustment parameter and a preset time slice length; determining whether the second device receives a second data packet sent by the first device based on the time slice length and the target time cycle of the second device; and in response to determining that the second device receives the second data packet sent by the first device, determining a time point for sending a data packet next time by the second device according to data packet information of the first device, achieving cycle synchronization of the second device in a preset synchronization cycle time period.

Abstract: A slide rail assembly includes a first rail, a second rail, a blocking feature, and a component. The two rails can be displaced with respect to each other. The blocking feature is provided at one of the two rails, and the component at the other of the two rails. When the second rail is at a predetermined position with respect to the first rail, a blocking portion of the blocking feature and a predetermined portion of the component are blocked by each other to prevent the second rail from being displaced with respect to the first rail from the predetermined position in a predetermined direction. One of the blocking portion and the predetermined portion forms a non-vertical structure.