Abstract: An acoustic tweezer is disclosed. The acoustic tweezer includes a function signal generator configured to generate a function signal for an ultrasound signal, a power amplifier configured to amplify the ultrasound signal based on the function signal, and an ultrasound transducer of a single channel in which a hologram thin film having different thin film thicknesses for each region is attached to an ultrasound oscillating surface of the ultrasound transducer, and the ultrasound transducer is configured to generate a plurality of ultrasound signals having different phase differences by allowing an oscillated ultrasound signal to pass through the hologram thin film.

Abstract: The training apparatus according to an embodiment includes: a support unit; a guide unit fixed on the support unit and including rails which extend in a front-rear direction; a sliding unit which is movable in the front-rear direction along the rails of the guide unit; a pillar-shaped rotation axis fixed on the support unit; a footrest unit which supports a user's foot; a lower support formed below the footrest unit; and a connection rotating unit formed below the footrest unit and connected to the rotation axis of the support unit through insertion to allow the footrest unit to rotate around the rotation axis. A plurality of springs installed inward from two sidewalls of the sliding unit is configured to come into contact with the lower support of the footrest unit and apply pressure from two sides when the footrest unit rotates.

Abstract: According to an embodiment of the present disclosure, there is provided a completely new type of 3-dimensional (3D) printing method for producing an object by focusing ultrasound onto material that changes in state by stimulation to solidify it into a desired shape. The method for 3D printing according to an embodiment includes providing material which changes in state by stimulation, setting a target focal point in the material, focusing ultrasound onto the target focal point using at least one ultrasound transducer, and applying stimulation to the material using the focused ultrasound to induce a change in state of the material. According to the embodiments, it is possible to control the precision of the output by controlling the frequency of the ultrasound transducer or the size of the target focal point on system.

Abstract: The present disclosure relates to a biodegradable polymer-gelatin hydrogel composite, a method for preparing the same and a medical implant including the biodegradable polymer-gelatin hydrogel composite. The multi-layered biodegradable polymer-gelatin hydrogel composite of the present disclosure, wherein the biodegradable polymer membrane of a 3D reticular structure and the gelatin hydrogel are stacked, has superior durability and resilience and may exhibit improved elasticity and swellability upon wetting under hydration environment. In addition, it can be shrunk down to 50% of its initial volume upon drying and can maintain elasticity even after the shrinkage. Furthermore, when used in a medical implant, it can protect the joint from the frictional environment in the body, reinforce the muscle torn or ruptured by trauma, relive pain by maintaining space, and induce the improvement of symptoms.

Abstract: A high-low intensity focused ultrasound treatment apparatus according to the present disclosure includes a plurality of ultrasound sources, and a controller to control a center frequency and intensity of focused ultrasound outputted from the ultrasound sources, wherein each of the ultrasound sources includes a first ultrasound transducer to output low-intensity focused ultrasound to detect a lesion, and a second ultrasound transducer to output high-intensity focused ultrasound to ablate or remove the detected lesion. The low-intensity focused ultrasound outputted from the first transducer may be used to detect a lesion in a patient's brain by applying a stimulus to the brain, and at the same time, investigating a response, and the high-intensity focused ultrasound outputted from the second transducer may be used to ablate or remove the detected lesion by applying a thermal or mechanical stimulus to the lesion.

Abstract: A guide framework for positioning an ultrasonic transducer which emits a focused ultrasound to a target point in carrying out surgery to apply ultrasonic stimulation to a subject's brain, includes a body in a shape of a mask that is laid on the subject's face, and a positioning hole formed through an inner surface and an outer surface of the mask body, the positioning hole into which the ultrasonic transducer is inserted, wherein the inner surface of the mask body is formed to conform a facial contour of the subject, and when the guide framework is laid on the subject's face and the ultrasonic transducer is disposed at the positioning hole, the position of the target point is naturally disposed at a preset stimulation site of the brain. An ultrasonic stimulation device includes an ultrasonic transducer and the guide framework for positioning the ultrasonic transducer.

Abstract: The training apparatus according to an embodiment includes: a support unit; a guide unit fixed on the support unit and including rails which extend in a front-rear direction; a sliding unit which is movable in the front-rear direction along the rails of the guide unit; a pillar-shaped rotation axis fixed on the support unit; a footrest unit which supports a user's foot; a lower support formed below the footrest unit; and a connection rotating unit formed below the footrest unit and connected to the rotation axis of the support unit through insertion to allow the footrest unit to rotate around the rotation axis. A plurality of springs installed inward from two sidewalls of the sliding unit is configured to come into contact with the lower support of the footrest unit and apply pressure from two sides when the footrest unit rotates.

Abstract: The present invention relates to a stress analysis method including: acquiring bio-signals from a test subject; calculating a probability of each of a plurality of stress level values by processing the bio-signals using a deep neural network algorithm; estimating a stress level value with the maximum probability of the plurality of stress level values as a stress level value of the test subject; determining usefulness of the estimated stress level value; and outputting the estimated stress level value determined to be useful through the determination of usefulness, as the final stress level.

Abstract: A bidirectional self-healing neural interface includes a first elastic substrate; a neural electrode disposed on the first elastic substrate and comprising a conductive polymer composite; and a second elastic substrate disposed on the neural electrode. The conductive polymer composite includes a matrix formed of a self-healing polymer material; and a plurality of electrical conductor clusters distributed in the matrix. Each of the electrical conductor clusters includes particles of a first electrical conductor; and a plurality of particles of a second electrical conductor formed of the same material as that of the first electrical conductor, distributed around each of the particles of the first electrical conductor, and having sizes that are smaller than those of the particles of the first electrical conductor. The first electrical conductor is a source for generating the second electrical conductor.

Abstract: An apparatus for tissue ablation according to an embodiment of the present disclosure includes an ultrasound output unit to output focused ultrasound, and a control unit to control an intensity of the focused ultrasound, wherein the control unit may be configured to control the intensity of the focused ultrasound below a setting value, when a first condition in which a vapor bubble is formed in a tissue or a second condition in which a temperature of the tissue reaches a threshold is accomplished during the output of the focused ultrasound to the tissue. According to this embodiment, it is possible to precisely control vapor bubble dynamics without generating the shockwave scattering effect by instantaneously controlling the acoustic pressure and the intensity of the focused ultrasound, and prevent damage to a tissue other than a lesion to be removed.

Abstract: Provided is a bidirectional neural interface having excellent elasticity and electrical conductivity improved by deformation, and further having self-healability and a method of manufacturing the same. The bidirectional neural interface includes a first elastic substrate, a neural electrode disposed on the first elastic substrate and including a conductive polymer composite, and a second elastic substrate disposed on the neural electrode, wherein the conductive polymer composite includes a matrix formed of a self-healing polymer material, and a plurality of electrical conductor clusters distributed in the matrix, wherein each of the electrical conductor clusters includes particles of a first electrical conductor, and a plurality of particles of a second electrical conductor formed of the same material as that of the first electrical conductor, distributed around each of the particles of the first electrical conductor and having smaller sizes than sizes of the particles of the first electrical conductor.

Abstract: According to an embodiment of the present disclosure, there is provided a completely new type of 3-dimensional (3D) printing method for producing an object by focusing ultrasound onto material that changes in state by stimulation to solidify it into a desired shape. The method for 3D printing according to an embodiment includes providing material which changes in state by stimulation, setting a target focal point in the material, focusing ultrasound onto the target focal point using at least one ultrasound transducer, and applying stimulation to the material using the focused ultrasound to induce a change in state of the material. According to the embodiments, it is possible to control the precision of the output by controlling the frequency of the ultrasound transducer or the size of the target focal point on system.

Abstract: The present invention relates to a stress analysis method including: acquiring bio-signals from a test subject; calculating a probability of each of a plurality of stress level values by processing the bio-signals using a deep neural network algorithm; estimating a stress level value with the maximum probability of the plurality of stress level values as a stress level value of the test subject; determining usefulness of the estimated stress level value; and outputting the estimated stress level value determined to be useful through the determination of usefulness, as the final stress level.

Abstract: A high-low intensity focused ultrasound treatment apparatus according to the present disclosure includes a plurality of ultrasound sources, and a controller to control a center frequency and intensity of focused ultrasound outputted from the ultrasound sources, wherein each of the ultrasound sources includes a first ultrasound transducer to output low-intensity focused ultrasound to detect a lesion, and a second ultrasound transducer to output high-intensity focused ultrasound to ablate or remove the detected lesion. The low-intensity focused ultrasound outputted from the first transducer may be used to detect a lesion in a patient's brain by applying a stimulus to the brain, and at the same time, investigating a response, and the high-intensity focused ultrasound outputted from the second transducer may be used to ablate or remove the detected lesion by applying a thermal or mechanical stimulus to the lesion.

Abstract: A nerve probe array has a connector made of a flexible material; and a plurality of probes coupled to the connector, each of the plurality of probe having an electrode formed at a body thereof. The plurality of probes are arranged with intervals in a length direction of the connector, and the connector surrounds an outer circumference of a nerve, and the plurality of probes pierce the outer circumference of the nerve and are inserted into the nerve.

Abstract: An image registration system using a subject-specific tracker includes: a photographing unit for obtaining a scanning image; a fabricated tracker based on anatomical data of the user including tracking markers for defining relative positions; a recognizing unit configured to recognize positions of the tracking markers and an image registration unit configured to register the scanning image based on the positions of the tracking markers. According to the system, a body part of the user and a scanning image may be automatically registered without a conventional image registration process such as an attachment of a fiducial marker and a confirmation of the fiducial marker position using CT/MRI imaging. Accordingly, it is possible to minimize an error caused by human, ensure precise registration, allow trackers to be attached or detached as necessary during surgery operation, and keep the accuracy of registration after the trackers are attached or detached.

Abstract: A focused ultrasound stimulation apparatus according to the present disclosure includes a transducer which outputs low intensity/high intensity ultrasound, an acoustic lens which is placed in close contact with a user's skin and is customized to focus the ultrasound onto a target focal point, and a fixture for fixing the transducer and the acoustic lens to each other. The acoustic lens is customized using a 3-dimensional (3D) printer based on the pre-captured user's cranial shape, to focus the ultrasound a desired focus target for each user, thereby improving accuracy compared to conventional ultrasound stimulation apparatus.

Abstract: A guide framework for positioning an ultrasonic transducer which emits a focused ultrasound to a target point in carrying out surgery to apply ultrasonic stimulation to a subject's brain, includes a body in a shape of a mask that is laid on the subject's face, and a positioning hole formed through an inner surface and an outer surface of the mask body, the positioning hole into which the ultrasonic transducer is inserted, wherein the inner surface of the mask body is formed to conform a facial contour of the subject, and when the guide framework is laid on the subject's face and the ultrasonic transducer is disposed at the positioning hole, the position of the target point is naturally disposed at a preset stimulation site of the brain. An ultrasonic stimulation device includes an ultrasonic transducer and the guide framework for positioning the ultrasonic transducer.

Abstract: Disclosed is an apparatus for measuring electrocardiogram (ECG) using wireless communication, including a first measuring device and a second measuring device connected to each other using wireless communication, wherein the first measuring device includes a first electrode configured to measure a first signal generated by a heartbeat, and a slave signal generation unit configured to generate a slave signal based on the first signal and a wireless virtual ground signal received from the second measuring device, and the second measuring device includes a second electrode configured to measure a second signal generated by a heartbeat, a ground electrode configured to measure a ground signal, a wireless virtual ground unit configured to generate the wireless virtual ground signal based on the ground signal, and an ECG measuring unit configured to measure ECG based on the slave signal, the second signal, and the wireless virtual ground signal.

Abstract: The present disclosure relates to a method for in vivo targeting of a nanoparticle via bioorthogonal copper-free click chemistry, more particularly to a method for in vivo targeting of a nanoparticle, including: injecting a precursor capable of being metabolically engineered in vivo when injected into a living system and having a first bioorthogonal functional group into the living system; and injecting a nanoparticle having a second bioorthogonal functional group which can perform a bioorthogonal copper-free click reaction with the first bioorthogonal functional group attached thereto into the living system. In accordance with the present disclosure, accumulation of nanoparticles at a target site in a living system can be increased remarkably and the biodistribution of the nanoparticles can be controlled since the nanoparticles bound to a cell surface are taken up into the cell with time.