Patents by Inventor Inchul You

Inchul You has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ERK5 DEGRADERS AND USES THEREOF
    Publication number: 20240374737
    Abstract: Described are the bifunctional compounds, compositions and methods of treating a disease or disorder characterized by aberrant extracellular-signal-regulated kinase 5 (ERK5) activity.
    Type: Application
    Filed: September 19, 2022
    Publication date: November 14, 2024
    Applicant: DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: Inchul You, Eric Wang, Nathanael S. Gray
  • SMALL MOLECULE CYCLIN DEPENDENT KINASE 4/6 (CDK4/6) AND IKZF2 (HELIOS) DEGRADERS AND METHODS OF USE THEREOF
    Publication number: 20240376096
    Abstract: The present application provides bifunctional compounds that act as protein degradation inducing moieties for cyclin-dependent kinase 4 (CDK4), cyclin-dependent kinase 6 (CDK6) and Ikaros Family Zinc Finger 2 (IKZF2), also known as Helios. Also disclosed are methods for the treatment of disorders modulated by CDK4, CDK6, and IKZF2.
    Type: Application
    Filed: July 15, 2022
    Publication date: November 14, 2024
    Applicant: DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: Alyssa Verano, Eric Wang, Inchul You, Nathanael Gray
  • INHIBITORS OF THE PEPTIDYL-PROLYL CIS/TRANS ISOMERASE (PIN1) AND USES THEREOF
    Publication number: 20240197678
    Abstract: Disclosed are compounds which inhibit Pin1 activity, methods of making the compounds, pharmaceutical compositions containing the compounds, and methods of using the compounds to treat diseases or disorders characterized or mediated by dysregulated Pin1 activity.
    Type: Application
    Filed: March 18, 2022
    Publication date: June 20, 2024
    Applicants: DANA-FARBER CANCER INSTITUTE, INC., YEDA RESEARCH AND DEVLOPMENT CO. LTD.
    Inventors: Inchul You, Nathanael S. Gray, Tinghu Zhang, Sirano Dhe-Paganon, Nir London, Christian Dubiella
  • ERK5 DEGRADERS AS THERAPEUTICS IN CANCER AND INFLAMMATORY DISEASES
    Publication number: 20220378919
    Abstract: Disclosed are bispecific compounds (degraders) that target ERK5 for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the compounds to treat cancer and inflammatory diseases.
    Type: Application
    Filed: September 24, 2020
    Publication date: December 1, 2022
    Applicant: DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: Nathanael S. Gray, Jinhua Wang, Fleur Marcia Ferguson, Jie Jiang, Inchul You
  • DEGRADATION OF AKT BY CONJUGATION OF ATP-COMPETITIVE AKT INHIBITOR GDC-0068 WITH E3 LIGASE LIGANDS AND METHODS OF USE
    Publication number: 20220226481
    Abstract: Disclosed are bifunctional compounds comprising a GDC-0068 analog that binds AKT isoforms AKT1, 2 and 3, pharmaceutical compositions, and methods for treating diseases or conditions mediated by dysfunctional AKT activity.
    Type: Application
    Filed: April 8, 2020
    Publication date: July 21, 2022
    Applicants: DANA-FARBER CANCER INSTITUTE, INC., BETH ISRAEL DEACONESS MEDICAL CENTER, INC.
    Inventors: Nathanael Gray, Inchul You, Tinghu Zhang, Eric Fischer, Katherine Donovan, Emily Erickson, Alex Toker