Abstract: Provided herein are methods of treating a disorder ameliorated by activating muscarinic receptors in a patient 55 years or older in need thereof. The method comprises administering a total daily dose of between 25 and 200 mg xanomeline and/or a salt thereof and between 5 and 30 mg of a salt of trospium to the patient, such as a total daily dose of between 100 and 200 mg xanomeline and/or a salt thereof and between 20 and 30 mg of a salt of trospium. The present disclosure also provides a method for treating dementia-related psychosis and a method decreasing the risk of relapse in a patient having dementia-related psychosis.

Abstract: Provided herein are methods for treating a sleep disorder, e.g., insomnia, in a subject, comprising administering to the subject an effective amount of a compound having the formula or a pharmaceutically acceptable salt thereof.

Abstract: Provided herein are methods for treating a sleep disorder, e.g., insomnia, in a subject, comprising administering to the subject an effective amount of a compound having the formula (Compound 1) or a pharmaceutically acceptable salt thereof.