Patents by Inventor Indigo KING

Indigo KING has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant influenza antigens
    Patent number: 12630591
    Abstract: The invention provides recombinant influenza A hemagglutinin (HA) polypeptides, comprising an HA1 and a HA2 domain of an influenza A virus HA, and comprising an amino acid sequence wherein: (a) the amino acid at position 355 is W; and (b) the amino acid at position 432 is I and/or the amino acid at position 380 is I; and wherein the numbering of the amino acid positions in the amino acid sequence of the HA polypeptide is according to the numbering of amino acids in the amino acid sequence of HA from a reference H3N2 influenza strain, in particular the reference strain H3N2 A/Aichi/2/68 (SEQ ID NO: 1), immunogenic fragments thereof, nucleic acid molecules encoding said polypeptides or immunogenic fragments, and uses thereof.
    Type: Grant
    Filed: April 23, 2020
    Date of Patent: May 19, 2026
    Assignee: JANSSEN VACCINES & PREVENTION B.V.
    Inventors: Boerries Brandenburg, Tina Ritschel, Ferdinand Jacobus Milder, Mandy Antonia Catharina Jongeneelen, Indigo King, Yifan Song, Johannes Petrus Maria Langedijk
  • ENGINEERED TYPE II CAS POLYNUCLEOTIDES WITH REDUCED IMMUNOGENICITY AND USES THEREOF
    Publication number: 20260028648
    Abstract: Engineered Type II Cas polypeptides with reduced immunogenicity, CRISPR-Cas systems thereof, compositions thereof, delivery systems thereof, and methods of use thereof for modifying target polynucleotides, such as, for example, in cells.
    Type: Application
    Filed: October 2, 2025
    Publication date: January 29, 2026
    Inventors: Feng Zhang, Rumya Raghavan, Rhiannon Macrae, Yifan Song, Lucas Nivon, Indigo King
  • Influenza virus vaccines and uses thereof
    Patent number: 12454554
    Abstract: Provided herein are group 2 influenza hemagglutinin stem polypeptides, nucleic acids encoding said polypeptides, vectors comprising said nucleic acid and pharmaceutical compositions comprising the same, as well as methods of their use, in particular in the prevention and/or treatment of influenza virus infections.
    Type: Grant
    Filed: September 3, 2020
    Date of Patent: October 28, 2025
    Assignee: Janssen Vaccines & Prevention B.V.
    Inventors: Mandy Antonia Catharina Jongeneelen, Tina Ritschel, Ferdinand Jacobus Milder, Indigo King, Yifan Song, Johannes Petrus Maria Langedijk, Boerries Brandenburg
  • INFLUENZA VIRUS VACCINES AND USES THEREOF
    Publication number: 20230250135
    Abstract: Provided herein are group 2 influenza hemagglutinin stem polypeptides, nucleic acids encoding said polypeptides, vectors comprising said nucleic acid and pharmaceutical compositions comprising the same, as well as methods of their use, in particular in the prevention and/or treatment of influenza virus infections.
    Type: Application
    Filed: September 3, 2020
    Publication date: August 10, 2023
    Inventors: Mandy Antonia Catharina JONGENEELEN, Tina RITSCHEL, Ferdinand Jacobus MILDER, Indigo KING, Yifan SONG, Johannes Petrus Maria LANGEDIJK, Boerries BRANDENBURG
  • RECOMBINANT INFLUENZA ANTIGENS
    Publication number: 20220204567
    Abstract: The invention provides recombinant influenza A hemagglutinin (HA) polypeptides, comprising an HA1 and a HA2 domain of an influenza A virus HA, and comprising an amino acid sequence wherein: (a) the amino acid at position 355 is W; and (b) the amino acid at position 432 is I and/or the amino acid at position 380 is I; and wherein the numbering of the amino acid positions in the amino acid sequence of the HA polypeptide is according to the numbering of amino acids in the amino acid sequence of HA from a reference H3N2 influenza strain, in particular the reference strain H3N2 A/Aichi/2/68 (SEQ ID NO: 1), immunogenic fragments thereof, nucleic acid molecules encoding said polypeptides or immunogenic fragments, and uses thereof.
    Type: Application
    Filed: April 23, 2020
    Publication date: June 30, 2022
    Inventors: Boerries BRANDENBURG, Tina RITSCHEL, Ferdinand Jacobus MILDER, Mandy Antonia, Catharina JONGENEELEN, Indigo KING, Yifan SONG, Johannes Petrus, Maria LANGEDIJK