Abstract: A method to produce novel split-protein sensors are described herein. The method implements a sequence dissimilarity (SD) based design that can identify potential split-sites in proteins to generate a split-protein pair, and then employs structure guided mutagenesis of the fragmented protein interface to generate split-protein sensors. The sensors have a signal to background ratio >200 and can be readily used to monitor protein-protein interactions and their inhibition in cells.

Abstract: The present invention provides novel heterocyclic compounds as anticancer agents, especially as estrogen receptor (ER) antagonists/degraders and process for their preparation.

Abstract: The present invention provides novel heterocyclic compounds as anticancer agents, especially as estrogen receptor (ER) antagonists/degraders and process for their preparation.

Abstract: The present invention provides novel heterocyclic compounds as anticancer agents, especially as estrogen receptor (ER) antagonists/degraders and process for their preparation.

Abstract: The present invention provides novel heterocyclic compounds as anticancer agents, especially as estrogen receptor (ER) antagonists/degraders and process for their preparation.

Abstract: Provided are rapid and sensitive cell-free assay methods for detecting and/or measuring specific bimolecular or higher order interactions via reassembly of a split monomeric reporter protein, and methods of detecting or identifying modulators of such interactions by the effect on the signal provided by the reassembled split reporter protein. This methodology is adaptable to protein-protein, protein-peptide, protein-nucleic acid, protein-methylated or nonmethylated nucleic acid and other small or large molecule ligands and binding proteins.

Abstract: Provided are rapid and sensitive cell-free assay methods for detecting and/or measuring specific bimolecular or higher order interactions via reassembly of a split monomeric reporter protein, and methods of detecting or identifying modulators of such interactions by the effect on the signal provided by the reassembled split reporter protein. This methodology is adaptable to protein-protein, protein-peptide, protein-nucleic acid, protein-methylated or nonmethylated nucleic acid and other small or large molecule ligands and binding proteins.

Abstract: The present invention provides a nucleotide sequence detection system in which a reporter enzyme is split into two halves each half of which is associated with at least one zinc finger domain. Upon DNA binding to the specific sequence defined by the zinc finger domains associated with the respective halves, the split-protein reassembles to reconstitute a functional enzyme. As such, the present invention provides methods of using the nucleotide sequence detection system for various diagnostic and identification purposes.

Abstract: A configurable filter module for providing shared filter resource between an overlay engine and a texture mapping engine of a graphics system. The configurable filter may comprise a plurality of linear blend units each of which receives data input from one of the overlay engine and a mapping engine cache, and generates a linear blend filter output respectively; and a filter output multiplexer which receives data output from the linear blend units and selects a proper byte ordering output, wherein the linear blend units serve as an overlay interpolator filter to perform linear blending of the data input from the overlay engine during a linear blend mode, and serve as a texture bilinear filter to perform bilinear filtering of the data input from the mapping engine cache during a bilinear filtering mode.

Abstract: The present invention provides a system and a method for filtering a plurality of frames sent between devices coupled to a fabric by Fiber Channel connections. Frames are reviewed against a set of individual frame filters. Each frame filter is associated with an action, and actions selected by filter matches are prioritized. Groups of devices are “zoned” together and frame filtering ensures that restrictions placed upon communications between devices within the same zone are enforced. Zone group filtering is also used to prevent devices not within the same zone from communicating. Zoning may also be used to create LUN-level zones, protocol zones, and access control zones. In addition, individual frame filters may be created that reference selected portions of frame header or frame payload fields.

Abstract: A configurable filter module for providing shared filter resource between an overlay engine and a texture mapping engine of a graphics system. The configurable filter may comprise a plurality of linear blend units each of which receives data input from one of the overlay engine and a mapping engine cache, and generates a linear blend filter output respectively; and a filter output multiplexer which receives data output from the linear blend units and selects a proper byte ordering output, wherein the linear blend units serve as an overlay interpolator filter to perform linear blending of the data input from the overlay engine during a linear blend mode, and serve as a texture bilinear filter to perform bilinear filtering of the data input from the mapping engine cache during a bilinear filtering mode.

Abstract: The present invention provides a method for identifying a polypeptide that interacts with a known protein, which method uses fusion proteins with GFP fragments.

Abstract: A configurable filter module for providing shared filter resource between an overlay engine and a texture mapping engine of a graphics system. The configurable filter may comprise a plurality of linear blend units each of which receives data input from one of the overlay engine and a mapping engine cache, and generates a linear blend filter output respectively; and a filter output multiplexer which receives data output from the linear blend units and selects a proper byte ordering output, wherein the linear blend units serve as an overlay interpolator filter to perform linear blending of the data input from the overlay engine during a linear blend mode, and serve as a texture bilinear filter to perform bilinear filtering of the data input from the mapping engine cache during a bilinear filtering mode.

Abstract: The present invention provides a system and a method for filtering a plurality of frames sent between devices coupled to a fabric by Fibre Channel connections. Frames are reviewed against a set of individual frame filters. Each frame filter is associated with an action, and actions selected by filter matches are prioritized. Groups of devices are “zoned” together and frame filtering ensures that restrictions placed upon communications between devices within the same zone are enforced. Zone group filtering is also used to prevent devices not within the same zone from communicating. Zoning may also be used to create LUN-level zones, protocol zones, and access control zones. In addition, individual frame filters may be created that reference selected portions of frame header or frame payload fields.

Abstract: The present invention provides a method for identifying a polypeptide that interacts with a known protein, which method uses fusion proteins with GFP fragments.

Abstract: The present invention provides assays using fusion proteins with GFP fragments and test polypeptides for investigating protein-protein interactions.

Abstract: A method, apparatus and system for storing data wherein pieces of data are selectively combined at times when a storage device is not able to accept requests to store data for a duration sufficient that multiple additional pieces of data have been received since the last request to store data was made and at least two of those pieces of data are able to be combined into a piece of data that is better configured for storage.

Abstract: A configurable filter module for providing shared filter resource between an overlay engine and a texture mapping engine of a graphics system. The configurable filter may comprise a plurality of linear blend units each of which receives data input from one of the overlay engine and a mapping engine cache, and generates a linear blend filter output respectively; and a filter output multiplexer which receives data output from the linear blend units and selects a proper byte ordering output, wherein the linear blend units serve as an overlay interpolator filter to perform linear blending of the data input from the overlay engine during a linear blend mode, and serve as a texture bilinear filter to perform bilinear filtering of the data input from the mapping engine cache during a bilinear filtering mode.

Abstract: A configurable filter module for providing shared filter resource between an overlay engine and a texture mapping engine of a graphics system. The configurable filter may comprise a plurality of linear blend units each of which receives data input from one of the overlay engine and a mapping engine cache, and generates a linear blend filter output respectively; and a filter output multiplexer which receives data output from the linear blend units and selects a proper byte ordering output, wherein the linear blend units serve as an overlay interpolator filter to perform linear blending of the data input from the overlay engine during a linear blend mode, and serve as a texture bilinear filter to perform bilinear filtering of the data input from the mapping engine cache during a bilinear filtering mode.

Abstract: The present invention discloses a method of reconstituting, folding, or reassembling peptides or other binding pairs into a functionally active protein or other complex using an antiparallel leucine zipper. The present invention also provides assays using fusion proteins comprising GFP fragments and test polypeptides for investigating protein-protein interactions.