Abstract: A computer-implemented method for generating and/or delivering a radiation treatment plan is provided. The method comprises reading a modular radiation dose kernel that defines a three dimensional radiation isocenter dose formed from a sum of a plurality of radiation beams, reading serial slice data that define three dimensional closed surfaces representing a lesion, critical structure, or organ and generating a radiation treatment plan based on the radiation kernel file and the data that defines the three dimensional closed surface. The treatment plan can be translated for use by virtually any automated radiation delivery device.