Patents by Inventor Indrani Mukharji

Indrani Mukharji has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biosynthesis of zeaxanthin and glycosylated zeaxanthin in genetically engineered hosts
    Patent number: 5684238
    Abstract: DNA segments encoding the Erwinia herbicola enzymes geranylgeranyl pyrophosphate (GGPP) synthase, phytoene synthase, phytoene dehydrogenase-4H, lycopene cyclase, beta-carotene hydroxylase, and zeaxanthin glycosylase, DNA variants and analogs thereof encoding an enzyme exhibiting substantially the same biological activity, vectors containing those DNA segments, host cells containing the vectors and methods for producing those enzymes, zeaxanthin and zeaxanthin diglucoside by recombinant DNA technology in transformed host organisms are disclosed.
    Type: Grant
    Filed: July 22, 1993
    Date of Patent: November 4, 1997
    Assignee: Amoco Corporation
    Inventors: Rodney L. Ausich, Friedhelm Luetke Brinkhaus, Indrani Mukharji, John H. Proffitt, James G. Yarger, Huei-Che Bill Yen
  • Beta-carotene biosynthesis in genetically engineered hosts
    Patent number: 5656472
    Abstract: DNA segments encoding the Erwinia herbicola enzymes geranylgeranyl pyrophosphate (GGPP) synthase, phytoene synthase, phytoene dehydrogenase-4H and lycopene cyclase, vectors containing those DNA segments, host cells containing the vectors and methods for producing those enzymes and beta-carotene by recombinant DNA technology in transformed host organisms are disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 12, 1997
    Assignee: Amoco Corporation
    Inventors: Rodney L. Ausich, Friedhelm Luetke Brinkhaus, Indrani Mukharji, John Proffitt, James Yarger, Huei-Che Bill Yen
  • Phytoene biosynthesis in genetically engineered hosts
    Patent number: 5545816
    Abstract: DNA segments encoding the Erwinia herbicola enzymes geranylgeranyl pyrophosphate (GGPP) synthase and phytoene synthase, vectors containing those DNA segments, host cells containing the vectors and methods for producing those enzymes and phytoene by recombinant DNA technology in transformed host organisms are disclosed.
    Type: Grant
    Filed: July 19, 1993
    Date of Patent: August 13, 1996
    Assignee: Amoco Corporation
    Inventors: Rodney L. Ausich, Friedhelm L. Brinkhaus, Indrani Mukharji, John Proffitt, James Yarger, Huei-Che B. Yen
  • Beta-carotene biosynthesis in genetically engineered hosts
    Patent number: 5530188
    Abstract: DNA segments encoding the Erwinia herbicola enzymes geranylgeranyl pyrophosphate (GGPP) synthase, phytoene synthase, phytoene dehydrogenase-4H and lycopene cyclase, vectors containing those DNA segments, host cells containing the vectors and methods for producing those enzymes and beta-carotene by recombinant DNA technology in transformed host organisms are disclosed.
    Type: Grant
    Filed: July 21, 1993
    Date of Patent: June 25, 1996
    Assignee: Amoco Corporation
    Inventors: Rodney L. Ausich, Friedhelm L. Brinkhaus, Indrani Mukharji, John Proffitt, James Yarger, Huei-Che B. Yen
  • Lycopene biosynthesis in genetically engineered hosts
    Patent number: 5530189
    Abstract: DNA segments encoding the Erwinia enzymes geranylgeranyl pyrophosphate (GGPP) synthase, phytoene synthase and phytoene dehydrogenase-4H, vectors containing those DNA segments, host cells containing the vectors and methods for producing those enzymes and lycopene by recombinant DNA technology in transformed host organisms are disclosed.
    Type: Grant
    Filed: July 22, 1993
    Date of Patent: June 25, 1996
    Assignee: Amoco Corporation
    Inventors: Rodney L. Ausich, Friedhelm L. Brinkhaus, Indrani Mukharji, John Proffitt, James Yarger, Huei-Che B. Yen
  • Method and composition for increasing the accumulation of squalene and specific sterols in yeast
    Patent number: 5460949
    Abstract: A method of increasing the accumulation of squalene and specific sterols in yeast comprising increasing the expression level of a structural gene encoding a polypeptide having HMG-CoA reductase activity in a mutant yeast having single or double defects in the expression of sterol biosynthetic enzymes is provided. The expression level of a structural gene is preferably increased by transforming yeast with a recombinant DNA molecule comprising a vector operatively linked to an exogenous DNA segment that encodes a polypeptide having HMG-CoA reductase activity and a promoter that is suitable for driving the expression of the encoded polypeptide in the transformed yeast. The polypeptide having HMG-CoA reductase activity is preferably a truncated, active HMG-CoA reductase enzyme. Recombinant DNA molecules useful for transforming yeast and mutant yeast transformed with such recombinant DNA molecules are also disclosed.
    Type: Grant
    Filed: October 28, 1991
    Date of Patent: October 24, 1995
    Assignee: Amoco Corporation
    Inventors: Court A. Saunders, Fred R. Wolf, Indrani Mukharji