Abstract: A filter for tobacco smoke inhaling/generating/producing device, comprising stipulated amounts of specific grain sizes or combination of grain sizes of activated charcoal for effectively reducing from the mainstream smoke the level of p-benzosemiquinone (p-BSQ), a relatively stable highly reactive major harmful oxidant, without significantly affecting the flavor and taste of the smoke while providing comfortable mouthful of smoke and nicotine delivery, so that the charcoal filter cigarettes becomes potentially less hazardous safer cigarettes and may be acceptable to the smokers with marked reduction in health risk; the charcoal filters also effectively reduce the level of nitric oxide and tar from the mainstream smoke.

Abstract: The components of cigarette smoke, known until now, do not explain the overwhelming hazardous effects of smoking; this invention describes the isolation, identification and procedures for determination of the structure, properties and assay of a relatively stable major harmful oxidant (cs-oxidant) present in the cigarette smoke, the content of which is about 190±10 ?g per cigarette; the cs-oxidant alone almost quantitatively accounts for the oxidative damage of proteins produced by the aqueous extract of whole cigarette smoke, it is also responsible for the oxidative damage of DNA; since the cs-oxidant is relatively stable, it further explains the deleterious effects of the side stream smoke and passive smoking; a number of chemical compounds/agents including vitamin C have been found to prevent the cs-oxidant induced protein oxidation in vitro.

Abstract: The components of cigarette smoke, known until now, do not explain the overwhelming hazardous effects of smoking; this invention describes the isolation, identification and procedures for determination of the structure, properties and assay of a relatively stable major harmful oxidant (cs-oxidant) present in the cigarette smoke, the content of which is about 190±10 &mgr;g per cigarette; the cs-oxidant alone almost quantitatively accounts for the oxidative damage of proteins produced by the aqueous extract of whole cigarette smoke, it is also responsible for the oxidative damage of DNA; since the cs-oxidant is relatively stable, it further explains the deleterious effects of the side stream smoke and passive smoking; a number of chemical compounds/agents including vitamin C have been found to prevent the cs-oxidant induced protein oxidation in vitro.

Abstract: The components of cigarette smoke, known until now, do not explain the overwhelming hazardous effects of smoking; this invention describes the isolation, identification and procedures for determination of the structure, properties and assay of a relatively stable major harmful oxidant (cs-oxidant) present in the cigarette smoke, the content of which is about 190±10 &mgr;g per cigarette; the cs-oxidant alone almost quantitatively accounts for the oxidative damage of proteins produced by the aqueous extract of whole cigarette smoke, it is also responsible for the oxidative damage of DNA; since the cs-oxidant is relatively stable, it further explains the deleterious effects of the side stream smoke and passive smoking; a number of chemical compounds/agents including vitamin C have been found to prevent the cs-oxidant induced protein oxidation in vitro.

Abstract: The components of cigarette smoke, known until now, do not explain the overwhelming hazardous effects of smoking; this invention describes the isolation, identification and procedures for determination of the structure, properties and assay of a relatively stable major harmful oxidant (cs-oxidant) present in the cigarette smoke, the content of which is about 190±10 &mgr;g per cigarette; the cs-oxidant alone almost quantitatively accounts for the oxidative damage of proteins produced by the aqueous extract of whole cigarette smoke, it is also responsible for the oxidative damage of DNA; since the cs-oxidant is relatively stable, it further explains the deleterious effects of the side stream smoke and passive smoking; a number of chemical compounds/agents including vitamin C have been found to prevent the cs-oxidant induced protein oxidation in vitro.

Abstract: This invention relates to a filter for tobacco smoke inhaling/generating/producing device, comprising stipulated amounts of specific grain sizes or combination of grain sizes of activated charcoal for effectively reducing from the mainstream smoke the level of p-benzosemiquinone (p-BSQ), a relatively stable highly reactive major harmful oxidant, without significantly affecting the flavor and taste of the smoke while providing comfortable mouthful of smoke and nicotine delivery, so that the said charcoal filter cigarettes becomes potentially less hazardous safer cigarettes and may be acceptable to the smokers with marked reduction in health risk; the said charcoal filters also effectively reduce the level of nitric oxide and tar from the mainstream smoke.