Patents by Inventor Ines Höfig

Ines Höfig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Retroviral transduction using poloxamers
    Patent number: 11591617
    Abstract: The present invention relates to a method for transducing a target cell, the method comprising the step of contacting a target cell with a retroviral vector and a poloxamer having a molecular weight of 12.8 kDa to about 15 kDa. Further, the invention relates to the use of a poloxamer as defined herein, optionally in combination with a polycationic substance as defined herein, for transducing a target cell with a retroviral vector and a kit comprising a retroviral vector, a poloxamer as defined herein and, optionally, instructions for use.
    Type: Grant
    Filed: July 29, 2020
    Date of Patent: February 28, 2023
    Inventors: Natasa Anastasov, Ines Höfig, Christian Thirion
  • Retroviral transduction using poloxamers
    Patent number: 10815498
    Abstract: The present invention relates to a method for transducing a target cell, the method comprising the step of contacting a target cell with a retroviral vector and a poloxamer having a molecular weight of 12.8 kDa to about 15 kDa. Further, the invention relates to the use of a poloxamer as defined herein, optionally in combination with a polycationic substance as defined herein, for transducing a target cell with a retroviral vector and a kit comprising a retroviral vector, a poloxamer as defined herein and, optionally, instructions for use.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: October 27, 2020
    Inventors: Natasa Anastasov, Ines Höfig, Christian Thirion
  • Pseudotyped lentiviral vectors
    Patent number: 10072273
    Abstract: The present invention relates to a nucleic acid molecule comprising or consisting of a nucleic acid sequence encoding the vesicular stomatitis virus envelope glycoprotein (VSV-G) linked to a (poly)peptide comprising or consisting of a cell membrane-binding domain, said nucleic acid sequence comprising in 5? to 3? direction (a) a first sequence segment encoding an endoplasmic reticulum (ER) signal sequence; (b) a second sequence segment encoding said (poly)peptide comprising or consisting of a cell membrane-binding domain; (c) a third sequence segment encoding a linker; and (d) a fourth sequence segment encoding said VSV-G. Further, the invention relates to a vector comprising the nucleic acid molecule of the invention, a host cell comprising said vector or nucleic acid molecule, the polypeptide encoded by said nucleic acid molecule and a method of producing the polypeptide encoded by said nucleic acid molecule.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: September 11, 2018
    Assignees: Helmholtz Zentrum München—Deutsches Forschungszentrum Für Gesundheit Und Umwelt (GMBH), Sirion Biotech GmbH
    Inventors: Nata{hacek over (s)}a Anastasov, Ines Höfig, Christian Thirion
  • RETROVIRAL TRANSDUCTION USING POLOXAMERS
    Publication number: 20180016600
    Abstract: The present invention relates to a method for transducing a target cell, the method comprising the step of contacting a target cell with a retroviral vector and a poloxamer having a molecular weight of 12.8 kDa to about 15 kDa. Further, the invention relates to the use of a poloxamer as defined herein, optionally in combination with a polycationic substance as defined herein, for transducing a target cell with a retroviral vector and a kit comprising a retroviral vector, a poloxamer as defined herein and, optionally, instructions for use.
    Type: Application
    Filed: September 22, 2017
    Publication date: January 18, 2018
    Inventors: Natasa ANASTASOV, Ines Höfig, Christian Thirion
  • Retroviral transduction using poloxamers
    Patent number: 9771599
    Abstract: The present invention relates to a method for transducing a target cell, the method comprising the step of contacting a target cell with a retroviral vector and a poloxamer having a molecular weight of 12.8 kDa to about 15 kDa. Further, the invention relates to the use of a poloxamer as defined herein, optionally in combination with a polycationic substance as defined herein, for transducing a target cell with a retroviral vector and a kit comprising a retroviral vector, a poloxamer as defined herein and, optionally, instructions for use.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: September 26, 2017
    Inventors: Natasa Anastasov, Ines Höfig, Christian Thirion
  • PSEUDOTYPED LENTIVIRAL VECTORS
    Publication number: 20160333374
    Abstract: The present invention relates to a nucleic acid molecule comprising or consisting of a nucleic acid sequence encoding the vesicular stomatitis virus envelope glycoprotein (VSV-G) linked to a (poly)peptide comprising or consisting of a cell membrane-binding domain, said nucleic acid sequence comprising in 5? to 3? direction (a) a first sequence segment encoding an endoplasmic reticulum (ER) signal sequence; (b) a second sequence segment encoding said (poly)peptide comprising or consisting of a cell membrane-binding domain; (c) a third sequence segment encoding a linker; and (d) a fourth sequence segment encoding said VSV-G. Further, the invention relates to a vector comprising the nucleic acid molecule of the invention, a host cell comprising said vector or nucleic acid molecule, the polypeptide encoded by said nucleic acid molecule and a method of producing the polypeptide encoded by said nucleic acid molecule.
    Type: Application
    Filed: January 9, 2015
    Publication date: November 17, 2016
    Inventors: Natasa ANASTASOV, Ines HÖFIG, Christian THIRION
  • RETROVIRAL TRANSDUCTION USING POLOXAMERS
    Publication number: 20150064788
    Abstract: The present invention relates to a method for transducing a target cell, the method comprising the step of contacting a target cell with a retroviral vector and a poloxamer having a molecular weight of 12.8 kDa to about 15 kDa. Further, the invention relates to the use of a poloxamer as defined herein, optionally in combination with a polycationic substance as defined herein, for transducing a target cell with a retroviral vector and a kit comprising a retroviral vector, a poloxamer as defined herein and, optionally, instructions for use.
    Type: Application
    Filed: February 28, 2013
    Publication date: March 5, 2015
    Inventors: Natasa Anastasov, Ines Höfig, Christian Thirion