Abstract: Compound of formula (I) or pharmaceutically acceptable stereoisomers and/or salts thereof, alone or in combination with quinupristin or pharmaceutically acceptable salts thereof, for use in the treatment of tumors,

Abstract: Chemical entities are capable of inducing the degradation of the cellular prion protein (PrPC) identified with the pharmacological protein inactivation by folded intermediate targeting (PPI-FIT) methodology.

Abstract: A method of producing a di-substituted pyridinium polymer by microwave-assisted polymerisation of a 2, 3, or 4-substituted pyridine monomer of the formula NC5R4—R?—X, wherein R is selected from hydrogen, hydroxyl, and substituted or unsubstituted alkyl, alkoxy, aryl, alkaryl, aralkyl, and alkenyl groups, R? is a linking group, and X is a leaving group. Using this method, di-substituted pyridinium polymer compositions may be obtained wherein at least 50% of the di- substituted pyridinium polymer chains in the composition have the same degree of polymerisation.