Patents by Inventor Ing-Chien Chen
Ing-Chien Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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METHOD FOR SELECTING ANTIBODY FRAGMENTS, RECOMBINANT ANTIBODIES PRODUCED THEREFROM, AND USES THEREOF
Publication number: 20230212554Abstract: Disclosed herein are methods for selecting an antibody fragment specific to an influenza virus. According to certain embodiments of the present disclosure, the influenza virus may be influenza virus type A (IAV) or influenza virus type B (IBV). Also disclosed herein are the selected antibodies, recombinant antibody produced from the selected antibodies, and the uses thereof in the diagnosis of influenza virus infection.Type: ApplicationFiled: June 7, 2021Publication date: July 6, 2023Applicant: Academia SinicaInventors: An-Suei YANG, Chung-Ming YU, Ing-Chien CHEN, Chao-Ping TUNG, Hung-Pin PENG -
Patent number: 11434277Abstract: Disclosed herein are methods for high-throughput screening of a virus-specific neutralizing antibody. According to certain embodiments of the present disclosure, the virus is an influenza virus. Also disclosed herein are the antibodies selected by the high-throughput screening method, and the uses thereof in the prophylaxis and/or treatment of viral infection.Type: GrantFiled: October 19, 2018Date of Patent: September 6, 2022Assignee: ACADEMIA SINICAInventors: An-Suei Yang, Ing-Chien Chen, Yi-Kai Chiu, Chung-Ming Yu, Cheng-Chung Lee, Chao-Ping Tung, Yueh-Liang Tsou, Yi-Jen Huang, Chia-Lung Lin, Hong-Sen Chen, Hwei-Jiung Wang
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Publication number: 20220227843Abstract: The present invention provides binding molecules, including monoclonal antibodies, multi-specific antibodies, and antibody fragments, that specifically bind to the coronavirus, such as SARS-CoV-2, and methods of use thereof. In some aspects of the invention, the binding molecules are human antibodies, fragments, or derivatives thereof that specifically bind to SARS-CoV-2 spike protein. In some aspects of the invention, the binding molecules function to neutralize SARS-CoV-2. The present invention also relates to methods of using the binding molecules and compositions for diagnosis and treatment.Type: ApplicationFiled: January 12, 2022Publication date: July 21, 2022Applicant: Antaimmu BioMed Co., Ltd.Inventors: San-Tai Shen, Ing-Chien Chen, Kuang-Kai Liu, Frederick Y. Luh
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Publication number: 20210341478Abstract: Disclosed herein is a recombinant antibody against the nucleocapsid protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A kit containing the recombinant antibody for use in coronavirus detection is encompassed in the present disclosure. Also disclosed herein are in vitro methods of detecting coronavirus infection in a subject with the aid of the recombinant antibody.Type: ApplicationFiled: April 27, 2021Publication date: November 4, 2021Applicant: AnTaimmu BioMed Co., Ltd.Inventors: San-Tai SHEN, Shih-Hu HO, Ing-Chien CHEN
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Publication number: 20210070843Abstract: Disclosed herein are methods for high-throughput screening of a virus-specific neutralizing antibody. According to certain embodiments of the present disclosure, the virus is an influenza virus. Also disclosed herein are the antibodies selected by the high-throughput screening method, and the uses thereof in the prophylaxis and/or treatment of viral infection.Type: ApplicationFiled: October 19, 2018Publication date: March 11, 2021Inventors: An-Suei YANG, Ing-Chien CHEN, Yi-Kai CHIU, Chung-Ming YU, Cheng-Chung LEE, Chao-Ping TUNG, Yueh-Liang TSOU, Yi-Jen HUANG, Chia-Lung LIN, Hong-Sen CHEN, Hwei-Jiung WANG
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Patent number: 10472411Abstract: Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, that comprised a plurality of phage-displayed scFvs characterized with (1) a specific CS combination; (2) a specific distribution of aromatic residues in each CDR; and (3) a specific sequence in each CDR. The present scFv library could be used to efficiently produce different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.Type: GrantFiled: May 13, 2019Date of Patent: November 12, 2019Assignee: Academia SinicaInventors: An-Suei Yang, Hong-Sen Chen, Ing-Chien Chen, Chao-Ping Tung, Shin-Chen Hou, Chung-Ming Yu, Chi-Kai Yang, Yi-Kai Chiu
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Publication number: 20190263893Abstract: Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, that comprised a plurality of phage-displayed scFvs characterized with (1) a specific CS combination; (2) a specific distribution of aromatic residues in each CDR; and (3) a specific sequence in each CDR. The present scFv library could be used to efficiently produce different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.Type: ApplicationFiled: May 13, 2019Publication date: August 29, 2019Applicant: Academia SinicaInventors: An-Suei YANG, Hong-Sen CHEN, Ing-Chien CHEN, Chao-Ping TUNG, Shin-Chen HOU, Chung-Ming YU, Chi-Kai YANG, Yi-Kai CHIU
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Patent number: 10336816Abstract: Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, that comprised a plurality of phage-displayed scFvs characterized with (1) a specific CS combination; (2) a specific distribution of aromatic residues in each CDR; and (3) a specific sequence in each CDR. The present scFv library could be used to efficiently produce different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.Type: GrantFiled: February 23, 2016Date of Patent: July 2, 2019Assignee: Academia SinicaInventors: An-Suei Yang, Hong-Sen Chen, Ing-Chien Chen, Chao-Ping Tung, Shin-Chen Hou, Chung-Ming Yu, Chi-Kai Yang, Yi-Kai Chiu
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Patent number: 10336815Abstract: Disclosed herein are phage-displayed single-chain variable fragment (scFv) libraries, which comprised a plurality of scFvs with a specific sequence in each CDR. The present scFv libraries could be used to efficiently produce different antibodies with high binding affinity to H1 hemagglutinin of influenza virus. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.Type: GrantFiled: August 10, 2016Date of Patent: July 2, 2019Assignee: Academia SinicaInventors: An-Suei Yang, Ing-Chien Chen, Chao-Ping Tung, Chung-Ming Yu
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Patent number: 9951121Abstract: Disclosed are nucleic acid libraries for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and for facilitating production of a disulfide-stabilized single chain antibody. Also disclosed are host cell libraries and phage libraries including the nucleic acid libraries. Further disclosed are methods for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and methods for producing a disulfide-stabilized single chain antibody and non-fusion form thereof.Type: GrantFiled: March 8, 2016Date of Patent: April 24, 2018Assignee: Academic SinicaInventors: An-Suei Yang, Yu-Ching Lee, Ing-Chien Chen, Chung-Ming Yu, Hung-Ju Hsu, Yi-Jen Huang, Hung-Ju Chang, Keng-Chang Tsai, Hung-Pin Peng
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Publication number: 20180009877Abstract: Disclosed herein is a phage-displayed single-chain variable fragment (scFv) library, that comprised a plurality of phage-displayed scFvs characterized with (1) a specific CS combination; (2) a specific distribution of aromatic residues in each CDR; and (3) a specific sequence in each CDR. The present scFv library could be used to efficiently produce different antibodies with binding affinity to different antigens. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.Type: ApplicationFiled: February 23, 2016Publication date: January 11, 2018Applicant: Academia SinicaInventors: An-Suei YANG, Hong-Sen CHEN, Ing-Chien CHEN, Chao-Ping TUNG, Shin-Chen HOU, Chung-Ming YU, Chi-Kai YANG, Yi-Kai CHIU
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Publication number: 20170044239Abstract: Disclosed herein are phage-displayed single-chain variable fragment (scFv) libraries, which comprised a plurality of scFvs with a specific sequence in each CDR. The present scFv libraries could be used to efficiently produce different antibodies with high binding affinity to H1 hemagglutinin of influenza virus. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.Type: ApplicationFiled: August 10, 2016Publication date: February 16, 2017Applicant: Academia SinicaInventors: An-Suei YANG, Ing-Chien CHEN, Chao-Ping TUNG, Chung-Ming YU
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Publication number: 20160176952Abstract: Disclosed are nucleic acid libraries for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and for facilitating production of a disulfide-stabilized single chain antibody. Also disclosed are host cell libraries and phage libraries including the nucleic acid libraries. Further disclosed are methods for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and methods for producing a disulfide-stabilized single chain antibody and non-fusion form thereof.Type: ApplicationFiled: March 8, 2016Publication date: June 23, 2016Inventors: An-Suei Yang, Yu-Ching Lee, Ing-Chien Chen, Chung-Ming Yu, Hung-Ju Hsu, Yi-Jen Huang, Hung-Ju Chang, Keng-Chang Tsai, Hung-Pin Peng
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Patent number: 9309522Abstract: Disclosed are nucleic acid libraries for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and for facilitating production of a disulfide-stabilized single chain antibody. Also disclosed are host cell libraries and phage libraries including the nucleic acid libraries. Further disclosed are methods for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and methods for producing a disulfide-stabilized single chain antibody and non-fusion form thereof.Type: GrantFiled: May 20, 2013Date of Patent: April 12, 2016Assignee: Academia SinicaInventors: An-Suei Yang, Yu-Ching Lee, Ing-Chien Chen, Chung-Ming Yu, Hung-Ju Hsu, Yi-Jen Huang, Hung-Ju Chang, Keng-Chang Tsai, Hung-Pin Peng
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Publication number: 20130323787Abstract: Disclosed are nucleic acid libraries for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and for facilitating production of a disulfide-stabilized single chain antibody. Also disclosed are host cell libraries and phage libraries including the nucleic acid libraries. Further disclosed are methods for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and methods for producing a disulfide-stabilized single chain antibody and non-fusion form thereof.Type: ApplicationFiled: May 20, 2013Publication date: December 5, 2013Inventors: An-Suei Yang, Yu-Ching Lee, Ing-Chien Chen, Chung-Ming Yu, Hung-Ju Hsu, Yi-Jen Huang, Hung-Ju Chang, Keng-Chang Tsai, Hung-Pin Peng
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Publication number: 20110082052Abstract: Disclosed are nucleic acid libraries for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and for facilitating production of a disulfide-stabilized single chain antibody. Also disclosed are host cell libraries and phage libraries including the nucleic acid libraries. Further disclosed are methods for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and methods for producing a disulfide-stabilized single chain antibody and non-fusion form thereof.Type: ApplicationFiled: August 11, 2010Publication date: April 7, 2011Applicant: Academia SinicaInventors: An-Suei Yang, Yu-Ching Lee, Ing-Chien Chen, Chung-Ming Yu, Hung-Ju Hsu, Yi-Jen Huang, Hung-Ju Chang, Keng-Chang Tsai, Hung-Pin Peng