Patents by Inventor Ing-Jun Chen

Ing-Jun Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20110118464
    Abstract: The halogenated xanthine derivatives and the precursors thereof for anti-cancer and anti-metastasis activity and the preparation method thereof are provided. The halogenated xanthine derivatives can further be radio-labeled with the radioactive halide group. The growth of human prostate carcinoma, tongue squamous cell carcinoma, colon adenocarcinoma and lung carcinoma can be inhibited and arrested in G0/G1 phase by KMUP-2Cl (7-[2-[4-(chlorophenyl)-piperazinyl]ethyl]-1,3-dimethyl-8-chloroxanthine). In addition, the growth of human prostate carcinoma LNCaP can be inhibited by KMUP-1 (7-[2-[4-(2-chlorobenzene)-piperazinyl]-ethyl]-1,3-dimethyl-xanthine), and the LNCaP prostate cancer xenograft growth in nude mice is effectively inhibited by the intraperitoneal injection and per oral administration of KMUP-1.
    Type: Application
    Filed: November 18, 2009
    Publication date: May 19, 2011
    Inventor: Ing-Jun Chen
  • Publication number: 20100317671
    Abstract: A pharmaceutical composition for a treatment of an interstitial lung disease is provided. The pharmaceutical composition comprises an effective amount of an active component being one selected from a group consisting of a KMUP compound, a KMUP monoquaternary ammonium salt and a KMUP monoquaternary ammonium complex salt, wherein the KMUP monoquaternary ammonium complex salt is synthesized by the KMUP compound and a carboxylic acid derivative of one selected from a group consisting of a statin, a non-steroid anti-inflammatory (NSAIDs) and an anti-asthmatic drug.
    Type: Application
    Filed: July 7, 2010
    Publication date: December 16, 2010
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventor: Ing-Jun Chen
  • Publication number: 20100280040
    Abstract: A compound including a salt derivative of the chlorophenylpiperazine moiety is provided, wherein the chlorophenylpiperazine moiety is derived from the reaction of a xanthine and a piperazine. The salt derivative thereof is non-toxic to the tracheal smooth muscle cells (TSMCs) and can be intravenously-, orally- or sublingually-dosed into the mammals.
    Type: Application
    Filed: November 17, 2009
    Publication date: November 4, 2010
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventor: Ing-Jun Chen
  • Publication number: 20100280039
    Abstract: The invention relates to a pharmaceutical composition for treating serotonergic neurotransmission related disease or condition, including an effective amount of a chlorophenylpiperazine derived compound of Formula (I), or the pharmaceutically acceptable salt thereof. The pharmaceutical composition is safe and does not have side effect on lethargy.
    Type: Application
    Filed: November 17, 2009
    Publication date: November 4, 2010
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventor: Ing-Jun Chen
  • Publication number: 20100280041
    Abstract: A pharmaceutical composition for treating one of a cardiovascular disease and a pulmonary artery disease, comprising one of a first compound having a Formula I and a second compound having a Formula II.
    Type: Application
    Filed: December 3, 2009
    Publication date: November 4, 2010
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventor: Ing-Jun Chen
  • Publication number: 20100022552
    Abstract: A method for treating a spontaneous hypertension or a cardiomyocyte hypertrophy is provided. The method comprises a step of administering to a mammal a therapeutically effective amount of a compound of 7-[2-[4-(2-chlorobenzene)piperazinyl]ethyl]-1,3-dimethyl xanthine.
    Type: Application
    Filed: October 2, 2009
    Publication date: January 28, 2010
    Applicant: Kaohsiung Medical University
    Inventor: Ing-Jun CHEN
  • Publication number: 20100016329
    Abstract: The present invention provides a pharmaceutical composition including a compound of 7-[2-[4-(2-chlorophenyl)piperazinyl]-ethyl]-1,3-dimethylxanthine (KMUP-1), wherein the compound is a Rho-kinase inhibitor, and the pharmaceutical composition inhibits a physiological activity of a lung epithelial cell.
    Type: Application
    Filed: July 21, 2008
    Publication date: January 21, 2010
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventor: Ing-Jun Chen
  • Publication number: 20090306093
    Abstract: A method for treating a patient having lower urinary tract symptoms is provided. The method comprises a step of administering to the patient a therapeutically effective amount of one selected from a group consisting of a treating compound of 7-[2-[4-(2-Chlorobenzene)piperazinyl]ethyl]-1,3-dimethyl xanthine, a salt of the treating compound, a solvate of the treating compound and a combination thereof, wherein the compound has an effect on treating the benign prostate hyperplasia via a mechanism selected from a group consisting of an activation of PKG pathway, a blockage of an adrenoceptor, an opening of a potassium channel and an inhibition of PDE activity.
    Type: Application
    Filed: June 9, 2008
    Publication date: December 10, 2009
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventor: Ing-Jun Chen
  • Publication number: 20090209560
    Abstract: An anti-inflammation substrate for decreasing the proinflammation induced by the cytokines and inhibiting the lung function degeneration is provided. The anti-inflammation substrate includes one selected from the group consisting of a 7-[2-[4-(2-chlorobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine, a 7-[2-[4-(4-nitrobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine, a respective pharmaceutical acceptable salt thereof, and a combination thereof.
    Type: Application
    Filed: April 24, 2009
    Publication date: August 20, 2009
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Ing-Jun Chen, Bin-Nan Wu, Jwu-Lai Yeh
  • Patent number: 7550468
    Abstract: A variety of N-substituted derivatives are based upon the base chemicals of that provide for the induction of cavernosal relaxation in animals. R2 is a derivative based on a hetroaromatic group, an aromatic group or a cyclohexane.
    Type: Grant
    Filed: May 4, 2005
    Date of Patent: June 23, 2009
    Inventor: Ing-Jun Chen
  • Publication number: 20080312249
    Abstract: A pharmaceutical composition for treating the hypertension is provided. The pharmaceutical composition comprises a chemical compound of 7-[2-[4-(2-Chlorobenzene)piperazinyl]ethyl]-1,3-dimethyl xanthine and one of a pharmaceutical acceptable salt thereof and a solvate thereof, wherein the chemical compound treats the hypertension by cGMP-dependent inhibition on Rho kinase.
    Type: Application
    Filed: September 19, 2007
    Publication date: December 18, 2008
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventor: Ing-Jun CHEN
  • Publication number: 20080081816
    Abstract: An anti-inflammation substrate for decreasing the proinflammation induced by the cytokines and inhibiting the lung function degeneration is provided. The anti-inflammation substrate includes one selected from the group consisting of a 7-[2-[4-(2-chlorobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine, a 7-[2-[4-(4-nitrobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine, a respective pharmaceutical acceptable salt thereof, and a combination thereof.
    Type: Application
    Filed: October 3, 2006
    Publication date: April 3, 2008
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Ing-Jun Chen, Bin-Nan Wu, Jwu-Lai Yeh
  • Publication number: 20080064705
    Abstract: A substance for enhancing an aortic smooth muscle relaxation is provided. The substance is one selected from the group consisting of a compound of formula (I), a pharmaceutical acceptable therefrom and a solvate therefrom, wherein either of R1 and R2 is one of a hydrogen and a nitro group.
    Type: Application
    Filed: September 12, 2006
    Publication date: March 13, 2008
    Inventor: Ing-Jun Chen
  • Publication number: 20080051413
    Abstract: The effects of KMUP-3, (7-[2-[4-(4-Nitrobezene)peperazinyl]ethyl]-1,3-dimethylxanthine) on tracheal smooth muscle are provided. Intratracheal instillation of KMUP-3 avoids bronchoconstriction, decreases of lung resistance, and increases of dynamic lung compliance. These merits provide insightful benefits for the treatment in asthma and COPD (chronic obstructive pulmonary disease).
    Type: Application
    Filed: August 25, 2006
    Publication date: February 28, 2008
    Inventor: Ing-Jun Chen
  • Publication number: 20070104803
    Abstract: The present invention relates to a Chinese herbal composition for treating bacterial lipopolysaccharide-induced diseases. The composition is extracted from a mixture of Huang Qui, Huanglian and Dauhuang. The composition is used for treating a lung inflammation and a hypotension.
    Type: Application
    Filed: November 4, 2005
    Publication date: May 10, 2007
    Applicant: Kaohsiung Medical University
    Inventors: Ing-Jun Chen, Yi-Ching Lo, Yang-Chang Wu, Yi-Hung Tsai, Yung-Hsiung Lai
  • Patent number: 7105521
    Abstract: The present invention provides isoeugenol derivative compounds having the moiety and having ?2-adrenergic/5-HT2A antagonist, 5-HT re-uptake inhibition, and anti-oxidant activities.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: September 12, 2006
    Assignee: Syn-Tech Chem & Pharm Co., Ltd.
    Inventor: Ing-Jun Chen
  • Patent number: 6979687
    Abstract: The invention pertains to theophylline (1-methyl, 3-methyl xanthine) and IBMX (1-methyl, 3-isobutyl xanthine) derivatives of formulas I and II: where R1 is —CH3 or —CH2CH(CH3)2, and R2 is where R3 and R4 are independently selected from the group consisting of OCH3, CH3, NO2, F, Cl, Br and I.
    Type: Grant
    Filed: September 27, 2002
    Date of Patent: December 27, 2005
    Assignees: Cho-Jan Liang
    Inventor: Ing-Jun Chen
  • Publication number: 20050209242
    Abstract: A variety of N-substituted derivatives based upon the base chemicals of that provide for the induction of cavernosal relaxation in animals.
    Type: Application
    Filed: May 4, 2005
    Publication date: September 22, 2005
    Inventor: Ing-Jun Chen
  • Publication number: 20050209243
    Abstract: The present invention provides the pharmaceutical compositions for relaxing corpus the cavernosal smooth muscle, increasing the intracarvernosal pressure, and enhancing learning and memory activities.
    Type: Application
    Filed: May 23, 2005
    Publication date: September 22, 2005
    Inventor: Ing-Jun Chen
  • Patent number: 6887878
    Abstract: A compound having the following formula I: where R1 is an alkyl group or an alkenyl group, X represents R2 is selected from the group consisting of a halogen (o, m, p) group such as F, Cl, Br or I, —NH2, —NO2 and a hydrogen group, R3 is a hydrogen group or OH. The compound has pharmacologically ?2-adrenergic/5-HT2A antagonist activity, 5-HT re-uptake activity, and anti-oxidant activity. The compound is produced by preparing 4-epoxy isoeugenol, mixing piperazine dissolved in methanol with the 4-epoxy isoeugenol to reflux at 100° C. for approximately 2 to approximately 6 hours, removing the methanol, passing the mixture through a silica gel column chromatography after the removing step, eluting the passed mixture with n-hexane and ethyl acetate, drying the eluted mixture, and crystallizing the dried mixture with methanol.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: May 3, 2005
    Assignees: Ing-Jun Chen, Syn-Rech Chem & Phan Co., Ltd
    Inventor: Ing-Jun Chen