Patents by Inventor Ingeborg Lues
Ingeborg Lues has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20220274977Abstract: The invention relates to a compound of formula (1): A-B-D-E??(1) or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof, wherein: A is selected from monocyclic and bicyclic heteroaryl, which may independently substituted by alkyl or amino; B is selected from alkyl, heteroalkyl, alkyl-amino, aryl, heteroaryl, cycloalkyl, heterocyclyl and alkylene, wherein said groups may independently be substituted by alkyl; D is selected from aryl-amino, heteroaryl-amino, cycloalkyl-amino, heterocyclyl, heterocyclyl-amino, urea, thioamide, thiourea, sulfonamide, sulfoximine and sulfamoyl, wherein said aryl, heteroaryl, cycloalkyl and heterocyclyl groups may independently be substituted; and E is selected from aryl, heteroaryl, cycloalkyl, heterocyclyl, wherein said aryl, heteroaryl, cycloalkyl and heterocyclyl groups may independently be substituted. The compounds of formula (1) are inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5).Type: ApplicationFiled: May 5, 2022Publication date: September 1, 2022Inventors: Ulrich HEISER, Torsten HOFFMANN, Ingeborg LUES, Antje MEYER
-
Patent number: 11339152Abstract: The invention relates to a compound of formula (I): A-B-D-E (I) or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof, wherein: A is selected from monocyclic and bicyclic heteroaryl, which may independently substituted by alkyl or amino; B is selected from alkyl, heteroalkyl, alkyl-amino, aryl, heteroaryl, cycloalkyl, heterocyclyl and alkylene, wherein said groups may independently be substituted by alkyl; D is selected from aryl-amino, heteroaryl-amino, cycloalkyl-amino, heterocyclyl, heterocyclyl-amino, urea, thioamide, thiourea, sulfonamide, sulfoximine and sulfamoyl, wherein said aryl, heteroaryl, cycloalkyl and heterocyclyl groups may independently be substituted; and E is selected from aryl, heteroaryl, cycloalkyl, heterocyclyl, wherein said aryl, heteroaryl, cycloalkyl and heterocyclyl groups may independently be substituted. The compounds of formula (I) are inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5).Type: GrantFiled: April 3, 2018Date of Patent: May 24, 2022Inventors: Ulrich Heiser, Torsten Hoffmann, Ingeborg Lues, Antje Meyer
-
Publication number: 20200377493Abstract: The invention relates to a compound of formula (I): A-B-D-E (I) or a pharmaceutically acceptable salt, solvate or polymorph thereof, including all tautomers and stereoisomers thereof, wherein: A is selected from monocyclic and bicyclic heteroaryl, which may independently substituted by alkyl or amino; B is selected from alkyl, heteroalkyl, alkyl-amino, aryl, heteroaryl, cycloalkyl, heterocyclyl and alkylene, wherein said groups may independently be substituted by alkyl; D is selected from aryl-amino, heteroaryl-amino, cycloalkyl-amino, heterocyclyl, heterocyclyl-amino, urea, thioamide, thiourea, sulfonamide, sulfoximine and sulfamoyl, wherein said aryl, heteroaryl, cycloalkyl and heterocyclyl groups may independently be substituted; and E is selected from aryl, heteroaryl, cycloalkyl, heterocyclyl, wherein said aryl, heteroaryl, cycloalkyl and heterocyclyl groups may independently be substituted. The compounds of formula (I) are inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5).Type: ApplicationFiled: April 3, 2018Publication date: December 3, 2020Inventors: Ulrich HEISER, Torsten HOFFMANN, Ingeborg LUES, Antje MEYER
-
Patent number: 6037349Abstract: Imidazopyridine derivatives ad pharmacologically acceptable salts having antagonistic properties towards angiotensin II can be used for the treatment of hypertension, aldosteronism and cardiac insufficiency.Type: GrantFiled: January 4, 1999Date of Patent: March 14, 2000Assignee: Merck Patent GmbHInventors: Werner Mederski, Johannes Sombroek, Pierre Schelling, Norbert Beier, Ingeborg Lues, Klaus-Otto Minck
-
Patent number: 5798364Abstract: Imidazopyridine derivatives and pharmacologically acceptable salts having antagonistic properties towards angiotensin II can be used for the treatment of hypertension, aldosteronism and cardiac insufficiency.Type: GrantFiled: October 4, 1996Date of Patent: August 25, 1998Assignee: Merck Patent Gesellschaft mit Beschrankter HaftungInventors: Werner Mederski, Johannes Sombroek, Pierre Schelling, Norbert Beier, Ingeborg Lues, Klaus-Otto Minck
-
Patent number: 5684015Abstract: Described herein are novel imidazopyridine derivatives of the formula I ##STR1## wherein R is ##STR2## and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined in Patent Claim 1, and their salts, which exhibit antagonistic properties towards angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure, and of disorders of the central nervous system.Type: GrantFiled: September 14, 1995Date of Patent: November 4, 1997Assignee: Merck Patent Gesellschaft mit Beschrankter HaftungInventors: Werner Mederski, Matthias Osswald, Pierre Schelling, Klaus-Otto Minck, Dieter Dorsch, Norbert Beier, Ingeborg Lues
-
Patent number: 5532276Abstract: Novel imidazopyridine derivatives of the formula ##STR1## wherein R is ##STR2## and R.sup.1, R.sup.2, R.sup.3, R.sup.4, Ar.sup.1, X and Y are as defined in the specification, and their salts, exhibit antagonistic properties toward angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure, and of disorders of the central nervous system.Type: GrantFiled: December 5, 1994Date of Patent: July 2, 1996Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Werner Mederski, Dieter Dorsch, Mathias Osswald, Norbert Beier, Pierre Schelling, Klaus-Otto Minck, Ingeborg Lues
-
Patent number: 5476857Abstract: Novel imidazopyridine derivatives of formula I: ##STR1## wherein R is ##STR2## and R.sup.1, R.sup.2, R.sup.3, R.sup.4, X and Y are as defined herein, and their salts, exhibit antagonistic properties toward angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure, and of disorders of the central nervous system.Type: GrantFiled: June 17, 1993Date of Patent: December 19, 1995Assignee: Merck Patent Gesellschaft mit Beschrankter HaftungInventors: Werner Mederski, Dieter Dorsch, Norbert Beier, Pierre Schelling, Ingeborg Lues, Klaus-Otto Minck, Mathias Osswald
-
Patent number: 5461066Abstract: 4-amino-1-piperidylbenzoylguanidines of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the given meanings, and also the physiologically compatible salts thereof, exhibit antiarrhythmic properties and act as inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter.Type: GrantFiled: February 9, 1995Date of Patent: October 24, 1995Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Rolf Gericke, Manfred Baumgarth, Dieter Dorsch, Norbert Beier, Klaus-Otto Minck, Ingeborg Lues
-
Patent number: 5438063Abstract: Novel imidazopyridine derivatives of formula I ##STR1## wherein ##STR2## and R.sup.1, R.sup.2, R.sup.3, R.sup.4, X and Y are as defined herein, and their salts, exhibit antagonistic properties toward angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure, and of disorders of the central nervous system.Type: GrantFiled: June 6, 1994Date of Patent: August 1, 1995Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Mathias Osswald, Werner Mederski, Dieter Dorsch, Pierre Schelling, Norbert Beier, Ingeborg Lues, Klaus-Otto Minck
-
Patent number: 5405964Abstract: Novel imidazopyridine derivatives of formula I ##STR1## and X, --Y.dbd.Z--, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 as defined herein, and their salts, exhibit antagonistic properties towards angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure, and of disorders of the central nervous system.Type: GrantFiled: October 22, 1993Date of Patent: April 11, 1995Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Werner Mederski, Dieter Dorsch, Andreas Bathe, Thorsten Hartig, Mathias Osswald, Norbert Beier, Pierre Schelling, Klaus-Otto Minck, Ingeborg Lues
-
Patent number: 5401738Abstract: Benzimidazole compounds of the formula I ##STR1## and salts thereof, exhibit antagonistic properties toward angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and an increased intraocular pressure, as well as disturbances of the central nervous system.Type: GrantFiled: June 11, 1993Date of Patent: March 28, 1995Assignee: Merck Patent Gesellschaft mit beschrankterInventors: Werner Mederski, Dieter Dorsch, Norbert Beier, Pierre Schelling, Ingeborg Lues, Klaus-Otto Minck, Mathias Osswald
-
Patent number: 5389642Abstract: Novel imidazopyridine derivatives of the formula I ##STR1## in which R is ##STR2## and R.sup.1 to R.sup.4, X and Y are as defined herein, and their salts have antagonistic properties towards angiotensin(II) and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure and also disorders of the central nervous system.Type: GrantFiled: December 16, 1993Date of Patent: February 14, 1995Assignee: Merck Patent Gesellschaft Mit Beschrankter HaftungInventors: Dieter Dorsch, Werner Mederski, Mathias Osswald, Pierre Schelling, Norbert Beier, Ingeborg Lues, Klaus-Otto Minck
-
Patent number: 5378702Abstract: Thiadiazinones of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and n have the meaning given in claim 1, show antiarrhythmic action and are suitable for the control of cardiovascular disorders.Type: GrantFiled: July 16, 1993Date of Patent: January 3, 1995Assignee: Merck Patent Gesellschaft Mit Beschrankter HaftungInventors: Rochus Jonas, Ingeborg Lues, Klaus-Otto Minck, Michael Klockow
-
Patent number: 5371226Abstract: 2-oxoquinoline derivative of formula I; ##STR1## wherein R is ##STR2## and R.sup.1 to R.sup.6 and X are as defined in claim 1, and their salts exhibit antagonistic properties towards angiotensin II and have inter alia a hypotensive action.Type: GrantFiled: March 16, 1993Date of Patent: December 6, 1994Assignee: Merck Patent Gesellschaft Mit Beschrankter HaftungInventors: Werner Mederski, Dieter Dorsch, Norbert Beier, Ingeborg Lues, Klaus-Otto Minck, Pierre Schelling
-
Patent number: 5332750Abstract: New 1,2-dihydro-2-oxopyridines of formula I ##STR1## in which R is the radical ##STR2## and R.sup.1 to R.sup.6 and X are as defined herein,and their salts, have antagonistic properties towards angiotensin II and can be used for the treatment of hypertension, aldosteronism and cardiac insufficiency.Type: GrantFiled: April 22, 1993Date of Patent: July 26, 1994Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Werner Mederski, Norbert Beier, Pierre Schelling, Ingeborg Lues, Klaus-Otto Minck
-
Patent number: 5242928Abstract: Novel imidazopyridine derivatives of formula I: ##STR1## wherein R is ##STR2## R.sup.1 is A, alkenyl or alkynyl each having up to 6 C atoms, R.sup.2 is H, COOH, COOA, CN, NO.sub.2, NHCOR.sup.5, NHSO.sub.2 R.sup.5 or 1H-tetrazol-5-yl,R.sup.3 is R.sup.5 --CO--alkyl, Ar--CO--alkyl, Het--CO--alkyl or Het-alkyl each having 1-6 C atoms in the alkyl moiety,R.sup.4 is H or Hal,R.sup.5 is alkyl having 1-6 C atoms, wherein one or more H atoms can also be replaced with F,X is absent or is --NH--CO--, --CO--NH--, --O--CH(COOH)--, --NH--CH(COOH)--, --NA--CH(COOH)--, --CH.dbd.C(COOH)--, --CH.dbd.C(CN)-- OR --CH.dbd.C(1H-tetrazol-t-yl)--,Y is O or S,A is alkyl having 1-6 C atoms,Ar is unsubstituted phenyl or phenyl monosubstituted by R.sup.5, OR.sup.5, COOH, COOA, CN, NO.sub.2, NH.sub.2, NHCOR.sup.5, NHSO.sub.2 R.sup.Type: GrantFiled: December 17, 1992Date of Patent: September 7, 1993Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Werner Mederski, Dieter Dorsch, Norbert Beier, Pierre Schelling, Ingeborg Lues, Klaus-Otto Minck
-
Patent number: 5238937Abstract: The invention relates to novel chroman derivatives of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8 and R.sup.9 have the meanings given in [Patent claim 1], and which, like their salts, show effects on the cardiovascular system and can be used for the treatment or prophylaxis of cardiac insufficiency, angina pectoris, high blood pressure, incontinence and alopecia.Type: GrantFiled: December 4, 1991Date of Patent: August 24, 1993Assignee: Merck Patent GesellschaftInventors: Rolf Gericke, Manfred Baumgarth, Ingeborg Lues, Jurgen Harting, Rolf Bergmann
-
Patent number: 5232944Abstract: Novel chroman derivatives of the formula I ##STR1## in which X is O or NR.sup.11,Z is CH.sub.2, O, S or CHHal,R.sup.1 and R.sup.5 are each A,R.sup.2 is H or A,R.sup.1 and R.sup.2 together are also alkylene having 3-6 C atoms,R.sup.3 is OH or OAc,R.sup.4 is H,R.sup.3 and R.sup.4 together are also a bond,R.sup.6 and R.sup.7 are each H, A, HO, AO, CHO, ACO, ACS, HOOC, AOOC, AO--CS, ACOO, A--CS--O, hydroxyalkyl, NO.sub.2, NH.sub.2, NHA, NA.sub.2, CN, F, Cl, Br, I, CF.sub.3, ASO, ASO.sub.2, AO--SO, AO--SO.sub.2, AcNH, AO--CO--NH, H.sub.2 NSO, HANSO, A.sub.2 NSO, H.sub.2 NSO.sub.2, HANSO.sub.2, A.sub.2 NSO.sub.2, H.sub.2 NCO, HANCO, A.sub.2 NCO, H.sub.2 NCS, HANCS, A.sub.2 NCS, ASONH, ASO.sub.2 NH, AOSONH, AOSO.sub.2 NH, ACO-alkyl, nitro-alkyl, cyanoalkyl, A--C(.dbd.NOH) or A--C(.dbd.NNH.sub.2),R.sup.8 and R.sup.9 are each H or A or together are .dbd.O or .dbd.S,R.sup.10 is H, Hal, CHO or CH.sub.2 OH,R.sup.11 is H, A, Ac or CH.sub.Type: GrantFiled: April 20, 1992Date of Patent: August 3, 1993Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Rolf Gericke, Manfred Baumgarth, Ingeborg Lues, Jacques De Peyer, Rolf Bergmann
-
Patent number: 5143924Abstract: Novel chroman derivatives of the formula I ##STR1## in which R.sup.1 to R.sup.6 and Z have the meanings given in Patent Claim 1, and their salts show effects on the cardiovascular system and can be used for the treatment or prophylaxis of cardiac insufficiency, angina pectoris, high blood pressure, incontinence and alopecia.Type: GrantFiled: July 23, 1990Date of Patent: September 1, 1992Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Rolf Gericke, Manfred Baumgarth, Ingeborg Lues, Rolf Bergmann, Jacques De Peyer