Patents by Inventor Ingeborg Stein

Ingeborg Stein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing ortho-alkylated benzoic acid derivatives
    Patent number: 6573404
    Abstract: The invention relates to a process for the preparation of ortho-alkylated benzoic acid derivatives of the formula I characterized in that an aryl bromide of the formula II is reacted with a secondary or tertiary organolithium compound and CO2.
    Type: Grant
    Filed: October 8, 2002
    Date of Patent: June 3, 2003
    Assignee: Merck Patent GmbH
    Inventors: Ekkehard Bartmann, Ingeborg Stein
  • METHOD FOR PRODUCING ORTHO-ALKYLATED BENZOIC ACID DERIVATIVES
    Publication number: 20030069444
    Abstract: The invention relates to a process for the preparation of ortho-alkylated benzoic acid derivatives of the formula I 1
    Type: Application
    Filed: October 8, 2002
    Publication date: April 10, 2003
    Applicant: MERCK KGAA
    Inventors: Ekkehard Bartmann, Ingeborg Stein
  • Method for producing ortho-alkylated benzoic acid derivatives
    Patent number: 6515143
    Abstract: The invention relates to a process for the preparation of ortho-alkylated benzoic acid derivatives of the formula I characterized in that an aryl bromide of the formula II is reacted with a secondary or tertiary organolithium compound and CO2.
    Type: Grant
    Filed: January 8, 2002
    Date of Patent: February 4, 2003
    Assignee: Merck KGaA
    Inventors: Ekkehard Bartmann, Ingeborg Stein
  • Method for producing ortho-alkylated benzoic acid derivatives
    Patent number: 6350904
    Abstract: The invention relates to a process for the preparation of ortho-alkylated benzoic acid derivatives of the formula I characterized in that an aryl bromide of the formula II is reacted with a secondary or tertiary organolithium compound and CO2.
    Type: Grant
    Filed: April 5, 2001
    Date of Patent: February 26, 2002
    Assignee: Merck KGaA
    Inventors: Ekkehard Bartmann, Ingeborg Stein
  • Method for producing enantiomer-free N-methyl-N-[(1S)-1-phenyl-2-((3S)-3-hydroxypyrolidine-1-yl)ethyl]-2,2-diphenylacetamide
    Patent number: 6344566
    Abstract: The invention relates to a novel process for the alternative preparation of N-methyl-N-[(1S)-1-phenyl-2-((3S)-3-hydroxypyrrolidin-1-yl)ethyl]-2,2-diphenylacetamide or N-methyl-N-[(1R)-1-phenyl-2-((3R)-3-hydroxypyrrolidin-1-yl)ethyl]-2,2-diphenylacetamide, and the novel compounds N-methyl-N-[(1S)-1-phenyl-2-((3S)-3-hydroxypyrrolidin-1-yl)ethane] and N-methyl-N[(1R)-1-phenyl-2-((3R)-3-hydroxypyrrolidin-1-yl) ethane], which are prepared as intermediates.
    Type: Grant
    Filed: January 26, 2001
    Date of Patent: February 5, 2002
    Assignee: Merck Patent GmbH
    Inventors: Andreas Bathe, Bernd Helfert, Karl-August Ackermann, Rudolf Gottschlich, Ingeborg Stein, Jens Budak
  • Ketotricyclo[5.2.1.0]decane derivatives
    Patent number: 6277357
    Abstract: The invention relates to ketotricyclo[5.2.1.0]-decane derivatives of the formula I wherein Phe is a phenyl group which is unsubstituted or substituted by 1 to 5 hydroxyl, alkyl or alkoxy groups having 1 to 10 C atoms, and their preparation and use as UV filters, in particular in cosmetic or pharmaceutical formulations.
    Type: Grant
    Filed: October 19, 1993
    Date of Patent: August 21, 2001
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Michael Schwarz, Ingeborg Stein, Ulrich Heywang, Jürgen Eckstein
  • .alpha.-hydroxyketoalkyl derivatives as light protection filters
    Patent number: 5968482
    Abstract: The invention relates to the use of .alpha.-hydroxyketoalkyl derivatives as light protection filters for cosmetic or pharmaceutical products, the .alpha.-hydroxyketoalkyl group being linked, if appropriate via a spacer, to a chromophoric group which has an absorption maximum in a wavelength range of between 280 and 400 nm and has a conjugated .pi.-electron system of at least 8 .pi.-electrons, and to new .alpha.-hydroxyalkyl derivatives, processes for their preparation and pharmaceutical and cosmetic formulations comprising these derivatives as light protection substances.
    Type: Grant
    Filed: September 20, 1996
    Date of Patent: October 19, 1999
    Assignee: Merck Patent Gesellschaft MIT Beschrankter Haftung
    Inventors: Roland Martin, Ingeborg Stein, Ulrich Heywang, Michael Schwarz, Thekla Kurz
  • Ketotricyclo[5.2.1.0]decane derivatives
    Patent number: 5628988
    Abstract: The invention relates to ketotricyclo[5.2.1.0]decane derivatives of the formula I ##STR1## wherein Phe is a phenyl group which is unsubstituted or substituted by 1 to 5 hydroxyl, alkyl or alkoxy groups having 1 to 10 C atoms,and their preparation and use as UV filters, in particular in cosmetic or pharmaceutical formulations.
    Type: Grant
    Filed: January 26, 1996
    Date of Patent: May 13, 1997
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Michael Schwarz, Ingeborg Stein, Ulrich Heywang, J urgen Eckstein
  • Use of .alpha.-hydroxyketoalkyl derivatives as light protection filters
    Patent number: 5600007
    Abstract: The invention relates to the use of .alpha.-hydroxyketoalkyl derivatives as light protection filters for cosmetic or pharmaceutical products, the .alpha.-hydroxyketoalkyl group being linked, if appropriate via a spacer, to a chromophoric group which has an absorption maximum in a wavelength range of between 280 and 400 nm and has a conjugated .pi.-electron system of at least 8 .pi.-electrons, and to new .alpha.-hydroxyalkyl derivatives, processes for their preparation and pharmaceutical and cosmetic formulations comprising these derivatives as light protection substances.
    Type: Grant
    Filed: October 15, 1993
    Date of Patent: February 4, 1997
    Assignee: Merck Gmbh
    Inventors: Roland Martin, Ingeborg Stein, Ulrich Heywang, Michael Schwarz, Thekla Kurz
  • Triazine derivatives with UV filter properties
    Patent number: 5520906
    Abstract: Triazine compounds of the formula I ##STR1## wherein Y is NH or O,R.sup.1 in each case independently of one another are a radical of the formula II ##STR2## wherein Phe is a phenylene group which is unsubstituted or substituted by 1 to 4 alkyl or alkoxy groups having 1 to 10 C atoms andX is H or --SO.sub.3 H,andR.sup.2 and R.sup.3in each case independently of one another are a radical of the formula Y-R.sup.1,oralkoxy, alkylamino, arylamino or aryloxy having 1 to 10 C atoms. Also, cosmetic formulations, medicaments and pharmaceutical formulations containing the compounds, particularly as filters for solar rays.
    Type: Grant
    Filed: August 12, 1994
    Date of Patent: May 28, 1996
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Ingeborg Stein, Michael Casutt, Ulrich Heywang, Roland Martin, Michael Schwarz
  • Use of benzimidazole derivatives as light protection filters
    Patent number: 5501850
    Abstract: The invention relates to the use of benzimidazole derivatives of the formula I, ##STR1## where R.sup.1, R.sup.2, R.sup.3, R.sup.4 and Ar have the meaning given in claim 1, as light protection filters in cosmetic formulations, at least one of the radicals R.sup.1 to R.sup.4 or an alkyl or alkoxy substituent of the group Ar containing at least 4 C atoms.
    Type: Grant
    Filed: October 13, 1993
    Date of Patent: March 26, 1996
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Ingeborg Stein, Ulrich Heywang, Alexander Putz, Roland Martin
  • Process for preparing 2-arylbenzimidazole-5-sulfonic acids
    Patent number: 5473079
    Abstract: The invention relates to an improved process for preparing 2-arylbenzimidazole-5-sulfonic acids of the formula I, ##STR1## in which Ar is unsubstituted phenyl or phenyl substituted by one or more C.sub.1 -C.sub.6 alkyl or alkoxy groups andm is 1, 2 or 3,wherein o-phenylenediamine is reacted in the presence of sulfuric acid at between room temperature and 250.degree. C. with a benzoic acid derivative of the formula IIAr(--X).sub.
    Type: Grant
    Filed: October 1, 1993
    Date of Patent: December 5, 1995
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Ulrich Heywang, Ingeborg Stein, Ulrich Fechtel, Michael Casutt, Gerald Faller, Hartmut Hartner
  • Benzylidenequinuclidinones
    Patent number: 5399563
    Abstract: The invention relates to benzylidene-quinuclidinone derivatives of the formula I ##STR1## in which R.sup.1 is A;R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are in each case independently of one another H, A, OA or OH; andA is a straight-chain or branched alkyl radical having 1 to 10 C atomsand processes for their preparation and their use in cosmetic and/or pharmaceutical preparations.
    Type: Grant
    Filed: July 1, 1993
    Date of Patent: March 21, 1995
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Ingeborg Stein, Roland Martin, Michael Casutt, Ulrich Heywang, Henning Bottcher, Gunther Holzemann
  • Dialkoxybenzylidene-camphor derivatives
    Patent number: 5144081
    Abstract: The invention relates to dialkoxybenzylidene-camphor derivatives of the formula I ##STR1## in which R.sup.1 and R.sup.2, in each case independently of one another, are a straight-chain or branched alkyl radical having 1 to 10 c atoms, andX is H or SO.sub.3 H,and to a process for their preparation and their use in cosmetic and pharmaceutical preparations.
    Type: Grant
    Filed: September 4, 1991
    Date of Patent: September 1, 1992
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Ulrich Heywang, Roland Martin, Ingeborg Stein