Patents by Inventor Ingegerd E. Hellstrom

Ingegerd E. Hellstrom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • pH-sensitive immunoconjugates and methods for their use in tumor therapy
    Patent number: 4997913
    Abstract: Novel pH-sensitive immunoconjugates which dissociate in low-pH tumor tissue, comprising a chemotherapeutic agent and an antibody reactive with a tumor-associated antigen are described. The chemotherapeutic agent is coupled to the antibody by a link which is unstable in low pH. The link may comprise a spacer consisting of a polyamino acid. Representative antibodies for use in these immunoconjugates include monoclonal antibodies which are not internalized by tumor cells.
    Type: Grant
    Filed: May 12, 1987
    Date of Patent: March 5, 1991
    Assignee: Oncogen
    Inventors: Karl E. Hellstrom, Ingegerd E. Hellstrom, Efraim Lavie