Abstract: The present invention relates to an apparatus and a method for automatically performing chemical, biochemical and biological analyses using the apparatus. The apparatus comprises: a plurality of subsystems for each performing different operations on microtiter plates; a transporting subsystem for automated movement of microtiter plates in three directions X, Y and Z in order to transport plates from one subsystem to another subsystem within the apparatus; a liquid handler comprising at least two liquid handling probes, wherein said liquid handler is integrated in the transporting subsystem; an insertion/removal subsystem for inserting, removing and storing microtiter plates and equipment for sampling and dilution operations, wherein said insertion/removal subsystem is mechanically operated, without the need for electrical components implemented in that subsystem.

Abstract: The invention relates to a method for the controlled dosage of a medicament as a function of time by means of a method for the determination of a corresponding dosage profile and corresponding control of a dosage instrument.

Abstract: The present invention relates to a device and a method for the verification and quantitative analysis of analytes and their application for the verification and quantitative analysis of mycotoxins.

Abstract: A disposable test cassette for qualitative and/or quantitative analysis of analytes, having a structured body having introduced cavities connected to one another by channels, at least one inlet for introducing a sample fluid containing the analyte, at least one reagent chamber in which one or more reagents are stored and at least one detection chamber in which a signal for detection or quantitative analysis of the analyte is detected, wherein a floor or ceiling of the detection chamber is a signal transducer or a window for detection of a signal, fluid cannot be drawn by capillary forces into the reagent chamber or to the opening, and at least the reagents in the reagent chamber are stored in dry form. Also disclosed is an apparatus for bioassaying analytes including the test cassette, and also a method for operating this apparatus.

Abstract: The present invention relates to an apparatus and a method for automatically performing chemical, biochemical and biological analyses.

Abstract: The invention relates to a phosphorus-containing polymer for coating dielectric materials, to processes for its preparation and to its use, as well as to an optical signal transducer having a coating of the polymer and to its use.

Abstract: The invention relates to an apparatus and a process for detection of mycotoxins and to kits suitable for carrying out said process.

Abstract: Provided are planar waveguide (“PWG”) detection chips that are used to perform multiplex PCR and kinetic PCR assays with a single fluorescent dye. The PWG detection chips are housed in PWG detection chambers that house at least one PWG chip. The PWG detection chambers may be in a single chamber or a dual chamber configuration. Also provided are methods for analyzing amplification products using the PWG detection chambers of the present invention.

Abstract: The invention relates to an assay based on resonance energy transfer (RET), comprising a first molecule grope A, which is marked with at least one energy donor, and at least one second molecule group B which is marked with at least one energy acceptor, the donor comprising a molecule or particle which can be energetically excited by an external radiation source and which is fluorescence enabled and the acceptor comprising a molecule or particle which can be excited by energy transfer via the donor with partial or complete quenching of the donor fluorescence, and the donor and/or acceptor comprise luminescing inorganic dope nanoparticles having an expansion of ?50 nanometers, emitting electromagnetic radiation with stokes or anti-stokes scattering after energetic excitation.

Abstract: The invention relates to a method for the controlled dosage of a medicament as a function of time by means of a method for the determination of a corresponding dosage profile and corresponding control of a dosage instrument.

Abstract: The invention relates to a phosphorus-containing polymer for coating dielectric materials, to processes for its preparation and to its use, as well as to an optical signal transducer having a coating of the polymer and to its use.

Abstract: The invention relates to a phosphorus-containing polymer for coating dielectric materials, to processes for its preparation and to its use, as well as to an optical signal transducer having a coating of the polymer and to its use.

Abstract: The invention relates to methods for detection of nucleic acids on a solid phase, combining high affinity and high specificity. More particularly, the invention relates to methods combining high-affinity hybridization with highly specific enzymatic discrimination in solid phase based nucleic acid assays. This invention further relates to kits containing the reagents necessary for carrying out the disclosed assays.

Abstract: An optical layer structure having at least two layers and also a sensor based on this layer structure are described. The layer structure comprises at least a substrate layer and at least one (light) waveguide layer and a coupling element for the coupling of the optical beam, the layer adjacent to the waveguide layer having a smaller refractive index than the waveguide layer, and at least one layer consisting of a photoaddressable polymer.

Abstract: The invention relates to a measuring arrangement for measuring electrical signals on biological membrane bodies, whereby an electroconductive acess into the membrane body is created by gap junction channels.

Abstract: An optical layer structure having at least two layers and also a sensor based on this layer structure are described. The layer structure comprises at least a substrate layer and at least one (light) waveguide layer and a coupling element for the coupling of the optical beam, the layer adjacent to the waveguide layer having a smaller refractive index than the waveguide layer, and at least one layer consisting of a photoaddressable polymer.

Abstract: Method for determining the dose of at least one active agent based on a genetic analysis. The method comprises analyzing specific genes for their nucleotide sequence or their expression levels of gene-specific proteins and/or RNA molecules. The gene-specific data is assigned one or more relevant physiological functions of the human or animal body, in particular those which have an influence on the metabolism, absorption, excretion or distribution of the active agent in the body. The gene-specific data and the assigned physiological functions are then integrated into a physiology-based pharmacokinetic model (PBPK model). The PBPK model integrates pharmacokinetic data relating to one or more active agents. The PBPK model may also receive and evaluate patient-specific data directly inputted and combined with data from a knowledge database comprising known values of pharmacokinetic parameters. The PBPK's integration of these data provide a calculation of the individual dose of the active agent.

Abstract: The invention relates to an assay based on resonance energy transfer (RET), comprising a first molecule grope A, which is marked with at least one energy donor, and at least one second molecule group B which is marked with at least one energy acceptor, the donor comprising a molecule or particle which can be energetically excited by an external radiation source and which is fluorescence enabled and the acceptor comprising a molecule or particle which can be excited by energy transfer via the donor with partial or complete quenching of the donor fluorescence, and the donor and/or acceptor comprise luminescing inorganic dope nanoparticles having an expansion of ?50 nanometers, emitting electromagnetic radiation with stokes or anti-stokes scattering after energetic excitation.

Abstract: The invention relates to methods for detection of nucleic acids on a solid phase, combining high affinity and high specificity. More particularly, the invention relates to methods combining high-affinity hybridization with highly specific enzymatic discrimination in solid phase based nucleic acid assays. This invention further relates to kits containing the reagents necessary for carrying out the disclosed assays.

Abstract: The invention relates to polymers containing silane groups and to the use thereof, as well as to devices coated therewith and to the use thereof.