Patents by Inventor Ingmar Hoerr

Ingmar Hoerr has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20110077287
    Abstract: The present invention relates to a pharmaceutical composition containing an mRNA that is stabilised by sequence modifications in the translated region and is optimised for the translation. The pharmaceutical composition according to the invention is particularly suitable as an inoculating agent as well as a therapeutic agent for tissue regeneration. In addition a process is described for determining sequence modifications that serve for the stabilisation and translation optimisation of mRNA.
    Type: Application
    Filed: May 26, 2010
    Publication date: March 31, 2011
    Applicant: CUREVAC GMBH
    Inventors: FLORIAN VON DER MÜLBE, INGMAR HOERR, STEVE PASCOLO
  • Publication number: 20100303851
    Abstract: The present invention relates to an immunostimulating agent comprising at least one chemically modified RNA. The invention furthermore relates to a vaccine which comprises at least one antigen in combination with the immunostimulating agent. The immunostimulating agent according to the invention and the vaccine according to the invention are employed in particular against infectious diseases or cancer diseases.
    Type: Application
    Filed: June 1, 2010
    Publication date: December 2, 2010
    Applicant: CUREVAC GMBH
    Inventors: INGMAR HOERR, FLORIAN VON DER MÜLBE, STEVE PASCOLO
  • Publication number: 20100305196
    Abstract: The present invention relates to an active (immunostimulatory) composition comprising at least one RNA, preferably an mRNA, encoding at least two (preferably different) antigens capable of eliciting an (adaptive) immune response in a mammal wherein the antigens are selected from the group consisting of PSA (Prostate-Specific Antigen), PSMA (Prostate-Specific Membrane Antigen), PSCA (Prostate Stem Cell Antigen), and STEAP (Six Transmembrane Epithelial Antigen of the Prostate). The invention furthermore relates to a vaccine comprising said active (immunostimulatory) composition, and to the use of said active (immunostimulatory) composition (for the preparation of a vaccine) and/or of the vaccine for eliciting an (adaptive) immune response for the treatment of prostate cancer (PCa), preferably of neoadjuvant and/or hormone-refractory prostate cancers, and diseases or disorders related thereto.
    Type: Application
    Filed: October 8, 2008
    Publication date: December 2, 2010
    Applicant: Cure Vac GmbH
    Inventors: Jochen Probst, Ingmar Hoerr, Thomas Lander
  • Publication number: 20100291156
    Abstract: The present invention relates to an active (immunostimulatory) composition comprising at least one RNA, preferably a mRNA, encoding at least two (preferably different) antigens capable of eliciting an (adaptive) immune response in a mammal. The invention furthermore relates to a vaccine comprising said active (immunostimulatory) composition, and to the use of said active (immunostimulatory) composition (for the preparation of a vaccine) and/or of the vaccine for eliciting an (adaptive) immune response for the treatment of lung cancer, particularly of non-small cell lung cancers (NSCLC), preferably selected from the three main sub-types squamous cell lung carcinoma, adenocarcinoma and large cell lung carcinoma, or of disorders related thereto. Finally, the invention relates to kits, particularly to kits of parts, containing the active (immunostimulatory) composition and/or the vaccine.
    Type: Application
    Filed: October 8, 2008
    Publication date: November 18, 2010
    Inventors: Marijke Barner, Jochen Probst, Thomas Lander, Ingmar Hoerr
  • Publication number: 20100239608
    Abstract: The present invention relates to a pharmaceutical composition containing an mRNA that is stabilised by sequence modifications in the translated region and is optimised for the translation. The pharmaceutical composition according to the invention is particularly suitable as an inoculating agent as well as a therapeutic agent for tissue regeneration. In addition a process is described for determining sequence modifications that serve for the stabilisation and translation optimisation of mRNA.
    Type: Application
    Filed: May 26, 2010
    Publication date: September 23, 2010
    Applicant: CUREVAC GMBH
    Inventors: FLORIAN VON DER MÜLBE, INGMAR HOERR, STEVE PASCOLO
  • Publication number: 20100189729
    Abstract: The present application describes an antibody-coding, non-modified or modified RNA and the use thereof for expression of this antibody, for the preparation of a pharmaceutical composition, in particular a passive vaccine, for treatment of tumours and cancer diseases, cardiovascular diseases, infectious diseases, auto-immune diseases, virus diseases and monogenetic diseases, e.g. also in gene therapy. The present invention furthermore describes an in vitro transcription method, in vitro methods for expression of this antibody using the RNA according to the invention and an in vivo method.
    Type: Application
    Filed: January 8, 2008
    Publication date: July 29, 2010
    Applicant: CURVAC GMBH
    Inventors: Ingmar Hoerr, Jochen Probst, Steve Pascolo
  • Publication number: 20100047261
    Abstract: The present application describes a base-modified RNA and the use thereof for increasing the expression of a protein and for the preparation of a pharmaceutical composition, especially a vaccine, for the treatment of tumours and cancer diseases, heart and circulatory diseases, infectious diseases, autoimmune diseases or monogenetic diseases, for example in gene therapy. The present invention further describes an in vitro transcription method, in vitro methods for increasing the expression of a protein using the base-modified RNA, and an in vivo method.
    Type: Application
    Filed: October 31, 2007
    Publication date: February 25, 2010
    Applicant: CureVac GmbH
    Inventors: Ingmar Hoerr, Florian Von Der Mulbe
  • Publication number: 20090324584
    Abstract: The present invention relates to a nucleic acid of the general formula (I): GlXmGn, or (II): ClXmCn, which may be modified by a lipid. The nucleic acid of the invention acts as an immune-stimulating agent inducing the innate immune response. The invention relates further to a pharmaceutical composition (in a first embodiment), each containing an immune-stimulating agent according to the invention in combination with a pharmaceutically active carrier/vehicle (and, optionally, further auxiliary substances, additives and/or further adjuvants). In another embodiment, the inventive nucleic acid is combined with at least one pharmaceutically active component, a pharmaceutically acceptable carrier/vehicle (and, optionally, further auxiliary substances, additives and/or further adjuvants).
    Type: Application
    Filed: July 31, 2007
    Publication date: December 31, 2009
    Applicant: CureVac GmbH
    Inventors: Ingmar Hoerr, Jochen Probst, Thomas Ketterer, Birgit Scheel
  • Publication number: 20080267873
    Abstract: The invention relates to the use of RNA and an aqueous injection buffer containing a sodium salt, a calcium salt and optionally a potassium salt and optionally lactate, in the preparation of a RNA injection solution for increasing RNA transfer and/or RNA translation into/in a host organism. The invention relates further to a RNA injection solution and to a method for increasing the RNA transfer and/or RNA translation of RNA in vivo and in vitro.
    Type: Application
    Filed: May 19, 2006
    Publication date: October 30, 2008
    Applicant: CUREVAC GMBH
    Inventors: Ingmar Hoerr, Steve Pascolo
  • Publication number: 20080171711
    Abstract: The present invention relates to a mixture which contains mRNA for vaccination, wherein at least one mRNA contains a domain which codes for at least one antigen from a tumor and at least one further mRNA contains a domain which codes for at least one immunogenic protein (polypeptide). The invention furthermore relates to a pharmaceutical composition which contains an mRNA mixture according to the invention, and to the use for the treatment of tumor diseases.
    Type: Application
    Filed: July 20, 2005
    Publication date: July 17, 2008
    Inventors: Ingmar Hoerr, Steve Pascolo
  • Publication number: 20080025944
    Abstract: The present invention relates to a method for immunostimulation in a mammal, which comprises a. administration of at least one mRNA containing a region which codes for at least one antigen of a pathogen or at least one tumour antigen, and b. administration of at least one cytokine, at least one cytokine mRNA, at least one CpG DNA or at least one adjuvant RNA. The invention likewise relates to a product and a kit comprising the mRNA and cytokine or cytokine mRNA or CpG DNA or adjuvant RNA of the invention.
    Type: Application
    Filed: August 31, 2005
    Publication date: January 31, 2008
    Inventors: Ingmar Hoerr, Steve Pascolo
  • Publication number: 20070280929
    Abstract: The present invention relates to an immune-stimulating adjuvant in the form of a lipid-modified nucleic acid, optionally in combination with further adjuvants. The invention relates further to a pharmaceutical composition and to a vaccine, each containing an immune-stimulating adjuvant according to the invention, at least one active ingredient and optionally a pharmaceutically acceptable carrier and/or further auxiliary substances and additives and/or further adjuvants. The present invention relates likewise to the use of the pharmaceutical composition according to the invention and of the vaccine according to the invention for the treatment of infectious diseases or cancer diseases. Likewise, the present invention includes the use of the immune-stimulating adjuvant according to the invention in the preparation of a pharmaceutical composition for the treatment of cancer diseases or infectious diseases.
    Type: Application
    Filed: May 14, 2007
    Publication date: December 6, 2007
    Applicant: CUREVAC GMBH
    Inventors: Ingmar Hoerr, Thomas Ketterer, Steve Pascolo
  • Publication number: 20060188490
    Abstract: The present invention relates to a pharmaceutical composition containing blood cells or haemopoietic cells, e.g. red blood cells (erythrocytes), granulocytes, mononuclear cells (PBMCs) and/or blood platelets, in combination with a pharmaceutically acceptable excipient and/or vehicle, wherein the cells are transfected with at least one mRNA comprising at least one region coding for at least one antigen. The invention further discloses a method of preparing the aforesaid pharmaceutical composition and the use of blood cells transfected in this way for the preparation of drugs or pharmaceutical compositions for immune stimulation against the antigens encoded by the mRNA. The subjects according to the invention are used especially for the therapy and/or prophylaxis of carcinoses or infectious diseases and can also be employed in gene therapy.
    Type: Application
    Filed: January 30, 2006
    Publication date: August 24, 2006
    Inventors: Ingmar Hoerr, Steve Pascolo, Florian Von Der Mulbe
  • Publication number: 20050250723
    Abstract: The present invention relates to an immunostimulating agent comprising at least one chemically modified RNA. The invention furthermore relates to a vaccine which comprises at least one antigen in combination with the immunostimulating agent. The immunostimulating agent according to the invention and the vaccine according to the invention are employed in particular against infectious diseases or cancer diseases.
    Type: Application
    Filed: December 28, 2004
    Publication date: November 10, 2005
    Inventors: Ingmar Hoerr, Florian Von Der Mulbe, Steve Pascolo
  • Publication number: 20050059624
    Abstract: The present invention relates to a pharmaceutical composition comprising at least one mRNA comprising at least one coding region for at least one antigen from a tumour, in combination with an aqueous solvent and preferably a cytokine, e.g. GM-CSF, and a process for the preparation of the pharmaceutical composition. The pharmaceutical composition according to the invention is used in particular for therapy and/or prophylaxis against cancer.
    Type: Application
    Filed: June 18, 2004
    Publication date: March 17, 2005
    Inventors: Ingmar Hoerr, Florian Mulbe, Steve Pascolo
  • Publication number: 20050032730
    Abstract: The present invention relates to a pharmaceutical composition comprising a modified mRNA that is stabilised by sequence modifications and optimised for translation. The pharmaceutical composition according to the invention is particularly well suited for use as an inoculating agent, as well as a therapeutic agent for tissue regeneration. In addition, a process is described for determining sequence modifications that promote stabilisation and translational efficiency of modified mRNA of the invention.
    Type: Application
    Filed: December 5, 2003
    Publication date: February 10, 2005
    Inventors: Florian Von Der Mulbe, Ingmar Hoerr, Steve Pascolo