Patents by Inventor Ingo Grunwald
Ingo Grunwald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10232079Abstract: Primarily described are gel-forming systems, consisting of or comprising a composition (A), comprising one or several cationically crosslinkable polymer(s), and a composition (B), comprising one or several crosslinking agent(s) for crosslinking the cationically crosslinkable polymer(s) for use in a method for removing urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, from a region of the urinary tract, more particularly a kidney, that contains urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, that are to be removed, with the following steps: (i) providing the compositions (A) and (B), (ii) introducing the compositions (A) and (B) into a region of the urinary tract, more particularly the kidney, that contains urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, that are to be removed, under conditions enabling crosslinking of the cationically crosslinkable polymer(sType: GrantFiled: August 22, 2013Date of Patent: March 19, 2019Assignees: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V., ALBERT-LUDWIGS-UNIVERITÄT FREIBURGInventors: Ingo Grunwald, Katharina Richter, Arkadiusz Miernik, Martin Schoenthaler
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Patent number: 10047230Abstract: An article, comprising a substrate and a polymer film attached to the substrate is provided, the polymer film comprising a first layer of a first polymer functionalized by a first functionalization compound covalently bound to said first polymer and bearing at least one catecholic group being present on a surface of the first layer. The polymer film is a layered film, a top layer of which is formed by the first layer, the layered film comprising at least one further layer of at least one further polymer functionalized by a further functionalization compound covalently bound to said further polymer and bearing at least one catecholic group being present on a surface of the at least one further layer, wherein an average ratio of catecholic groups per polymer molecule is equal to or less than 1 in case of the first polymer and greater than 1 in case of the further polymer.Type: GrantFiled: September 8, 2014Date of Patent: August 14, 2018Assignee: FREIE UNIVERSITÄT BERLINInventors: Rainer Haag, Marie Weinhart, Qiang Wei, Tobias Becherer, Ingo Grunwald
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Patent number: 10011825Abstract: The invention relates to a method for activating a surface by increasing the hydrophilicity and/or for binding target structures, particularly selected from the group consisting of proteins, cellular proteins, proteins, cells, carbohydrates, peptides and amino acids. It also relates to the use of an oxidoreductase for activating a surface for the mentioned bonds and to corresponding activated surfaces.Type: GrantFiled: June 14, 2013Date of Patent: July 3, 2018Assignee: FRAUNHOFER-GESELLSCHAFT ZUR FOERDERUNG DER AGNEWANDTEN FORSCHUNG E.V.Inventors: Michael Szardenings, Klaus Rischka, Ingo Grunwald, Annika Eisenschmidt
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Patent number: 9925311Abstract: Described is a kit for producing a crosslinked gel for surrounding urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, comprising a composition (A) comprising one or several cationically crosslinkable polymer(s), and a composition (B) comprising one or several crosslinking agent(s) for crosslinking the cationically crosslinkable polymer(s), wherein composition (A) and/or composition (B) additionally comprise(s) magnetizable particles or the kit additionally comprises a composition (C) that contains magnetizable particles. Upon contact of composition (A) with composition (B) in a region of the urinary tract, more particularly the kidney, that contains urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, a crosslinked gel is formed that partly or fully surrounds the urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, and that contains the magnetizable particles.Type: GrantFiled: August 22, 2013Date of Patent: March 27, 2018Assignee: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.Inventors: Ingo Grunwald, Katharina Richter, Arkadiusz Miernik, Martin Schoenthaler
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Publication number: 20160222224Abstract: An article, comprising a substrate and a polymer film attached to the substrate is provided, the polymer film comprising a first layer of a first polymer functionalized by a first functionalization compound covalently bound to said first polymer and bearing at least one catecholic group being present on a surface of the first layer. The polymer film is a layered film, a top layer of which is formed by the first layer, the layered film comprising at least one further layer of at least one further polymer functionalized by a further functionalization compound covalently bound to said further polymer and bearing at least one catecholic group being present on a surface of the at least one further layer, wherein an average ratio of catecholic groups per polymer molecule is equal to or less than 1 in case of the first polymer and greater than 1 in case of the further polymer.Type: ApplicationFiled: September 8, 2014Publication date: August 4, 2016Inventors: Rainer HAAG, Marie WEINHART, Qiang WEI, Tobias BECHERER, Ingo GRUNWALD
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Publication number: 20160074561Abstract: Described is a kit for producing a crosslinked gel for surrounding urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, comprising a composition (A) comprising one or several cationically crosslinkable polymer(s), and a composition (B) comprising one or several crosslinking agent(s) for crosslinking the cationically crosslinkable polymer(s), wherein composition (A) and/or composition (B) additionally comprise(s) magnetizable particles or the kit additionally comprises a composition (C) that contains magnetizable particles. Upon contact of composition (A) with composition (B) in a region of the urinary tract, more particularly the kidney, that contains urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, a crosslinked gel is formed that partly or fully surrounds the urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, and that contains the magnetizable particles.Type: ApplicationFiled: August 22, 2013Publication date: March 17, 2016Inventors: Ingo GRUNWALD, Katharina RICHTER, Arkadiusz MIERNIK, Martin SCHOENTHALER
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Publication number: 20160067373Abstract: Primarily described are gel-forming systems, consisting of or comprising a composition (A), comprising one or several cationically crosslinkable polymer(s), and a composition (B), comprising one or several crosslinking agent(s) for crosslinking the cationically crosslinkable polymer(s) for use in a method for removing urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, from a region of the urinary tract, more particularly a kidney, that contains urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, that are to be removed, with the following steps: (i) providing the compositions (A) and (B), (ii) introducing the compositions (A) and (B) into a region of the urinary tract, more particularly the kidney, that contains urinary calculi and/or fragments thereof, more particularly kidney stones and/or fragments thereof, that are to be removed, under conditions enabling crosslinking of the cationically crosslinkable polymer(sType: ApplicationFiled: August 22, 2013Publication date: March 10, 2016Inventors: Ingo GRUNWALD, Katharina RICHTER, Arkadiusz MIERNIK, Martin SCHOENTHALER
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Patent number: 9193986Abstract: Method for marking a target structure, comprising the following steps: a) providing a compound V that includes at least one dihydroxy- or trihydroxyphenyl group, b) providing a means for converting the dihydroxy- or trihydroxyphenyl group to a quinone group, c) providing a target structure, d) oxidizing the dihydroxy- or trihydroxyphenyl group of the compound V to the quinone group, and e) contacting the compound V with the target structure, so that a covalent bond can be formed, wherein in step e) the compound V is used in a concentration such that the maximum concentration of dihydroxy-, trihydroxyphenyl groups and quinone groups that are introduced by the compound V is ?500 ?M, preferably ?300 ?M, and more preferably ?100 ?M.Type: GrantFiled: September 13, 2013Date of Patent: November 24, 2015Assignee: FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E.V.Inventors: Michael Szardenings, Ingo Grunwald, Klaus Rischka, Katharina Richter
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Publication number: 20150159150Abstract: The invention relates to a method for activating a surface by increasing the hydrophilicity and/or for binding target structures, particularly selected from the group consisting of proteins, cellular proteins, proteins, cells, carbohydrates, peptides and amino acids. It also relates to the use of an oxidoreductase for activating a surface for the mentioned bonds and to corresponding activated surfaces.Type: ApplicationFiled: June 14, 2013Publication date: June 11, 2015Inventors: Michael Szardenings, Klaus Rischka, Ingo Grunwald, Annika Eisenschmidt
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Patent number: 8992590Abstract: The present invention relates to the use of a crosslinked, silicon-containing layer containing, substantially consisting of or consisting of silicon, O, C, H, optionally N which can be produced by plasma polymerization and/or crosslinking of organosilicon liquids by a plasma process and/or UV radiation of a wavelength of less than 250 nm, without using metals of an atomic number of more than 14, as a biocompatible surface, for imparting to a surface or providing a surface with a non-genotoxic effect. The invention also relates to correspondingly coated articles and to processes for the production thereof.Type: GrantFiled: July 31, 2009Date of Patent: March 31, 2015Assignees: Fraunhofer-Gesellschaft zur Forderung der Angewandten Forschung E.V., Bio-Gate AGInventors: Matthias Ott, Ingo Grunwald, Dirk Salz, Michael Wagener, Klaus-Dieter Vissing, Wolfgang Hielscher, Christopher Dölle
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Patent number: 8927205Abstract: The invention relates to polypeptides comprising, as constituent A, at least three monomers of a member of the TNF ligand family and, as constituent B, at least two peptide linkers that link the monomers of the member of the TNF ligand family to one another. The invention also relates to the use of these polypeptides for treating diseases and for producing a medicament or a vaccine. The invention also relates to methods for producing and isolating these polypeptides, to nucleic acids that code for these polypeptides, to vectors containing these nucleic acids, to host cells transfected with these vectors, and to pharmaceutical compositions containing these inventive objects. Finally, the invention relates to methods for the extracorporeal manipulation, depletion and/or removal of components contained in body fluids, e.g. by means of apheresis.Type: GrantFiled: March 24, 2005Date of Patent: January 6, 2015Assignee: Universitat of StuttgartInventors: Klaus Pfizenmaier, Peter Scheurich, Ingo Grunwald, Anja Krippner-Heidenreich
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Publication number: 20140162303Abstract: Method for marking a target structure, comprising the following steps: a) providing a compound V that includes at least one dihydroxy- or trihydroxyphenyl group, b) providing a means for converting the dihydroxy- or trihydroxyphenyl group to a quinone group, c) providing a target structure, d) oxidising the dihydroxy- or trihydroxyphenyl group of the compound V to the quinone group, and e) contacting the compound V with the target structure, so that a covalent bond can be formed, wherein in step e) the compound V is used in a concentration such that the maximum concentration of dihydroxy-, trihydroxyphenyl groups and quinone groups that are introduced by the compound V is ?500 ?M, preferably ?300 ?M, and more preferably ?100 ?M.Type: ApplicationFiled: September 13, 2013Publication date: June 12, 2014Inventors: Michael Szardenings, Ingo Grunwald, Klaus Rischka, Katharina Richter
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Publication number: 20110189493Abstract: The present invention relates to the use of a crosslinked, silicon-containing layer containing, substantially consisting of or consisting of silicon, O, C, H, optionally N which can be produced by plasma polymerization and/or crosslinking of organosilicon liquids by a plasma process and/or UV radiation of a wavelength of less than 250 nm, without using metals of an atomic number of more than 14, as a biocompatible surface, for imparting to a surface or providing a surface with a non-genotoxic effect. The invention also relates to correspondingly coated articles and to processes for the production thereof.Type: ApplicationFiled: July 31, 2009Publication date: August 4, 2011Inventors: Matthias Ott, Ingo Grunwald, Dirk Salz, Michael Wagener, Klaus-Dieter Vissing, Wolfgang Hielscher, Christopher Dölle
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Patent number: 7981313Abstract: The use of hydrophobins for preventing the formation of ice on surfaces, especially for the prevention of ice formation on aircraft surfaces.Type: GrantFiled: August 12, 2010Date of Patent: July 19, 2011Assignee: BASF SEInventors: Ulf Baus, Thorsten Montag, Thomas Subkowski, Claus Bollschweiler, Ingo Grunwald, Klaus Rischka
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Publication number: 20110017943Abstract: The use of hydrophobins for preventing the formation of ice on surfaces, especially for the prevention of ice formation on aircraft surfaces.Type: ApplicationFiled: August 12, 2010Publication date: January 27, 2011Applicant: BASF SEInventors: Ulf Baus, Thorsten Montag, Thomas Subkowski, Claus Bollschweiler, Ingo Grunwald, Klaus Rischka
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Publication number: 20100317039Abstract: The invention relates to a molding, comprising a matrix in a material, selected from the group consisting of metal, ceramic and polymer synthetic material, and coupling particles embedded in the matrix, wherein a proportion of the surface of the molding in a geometrical form or in a regular pattern and/or an area of the molding is completely or the entire surface of the molding is mechanically treated.Type: ApplicationFiled: June 1, 2010Publication date: December 16, 2010Inventors: Natalie Salk, Ingo Grunwald
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Publication number: 20070286843Abstract: The invention relates to polypeptides comprising, as constituent A, at least three monomers of a member of the TNF ligand family and, as constituent B, at least two peptide linkers that link the monomers of the member of the TNF ligand family to one another. The invention also relates to the use of these polypeptides for treating diseases and for producing a medicament or a vaccine. The invention also relates to methods for producing and isolating these polypeptides, to nucleic acids that code for these polypeptides, to vectors containing these nucleic acids, to host cells transfected with these vectors, and to pharmaceutical compositions containing these inventive objects. Finally, the invention relates to methods for the extracorporeal manipulation, depletion and/or removal of components contained in body fluids, e.g. by means of apheresis.Type: ApplicationFiled: March 24, 2005Publication date: December 13, 2007Applicant: Univeristat StuttgartInventors: Klaus Pfizenmaier, Peter Scheurich, Ingo Grunwald, Anja Krippner-Heidenreich