Abstract: A part-bearing-ring of a rolling-element bearing includes first and second assembly bores on its end surface, and the second assembly bore has a larger diameter than the first assembly bore so that it can accommodate a securing sleeve. The second assembly bore may include an internal thread for attaching the securing sleeve. Also a bearing ring formed of two part-bearing-rings and a securing sleeve and a method of installing a bearing ring.

Abstract: A rolling-element bearing support module includes a support for mounting on an end wall of a machine. The machine has a bore in the end wall and a shaft in the bore, and the shaft has an abutment surface in a plane of the end wall. A rolling-element bearing assembly of the module includes a first bearing and a second bearing on the shaft, and a side surface of the first bearing is aligned with a plane corresponding to the end surface of the machine. The first bearing is formed to transmit, via the side surface, axial forces in at least one direction and the second bearing is disposed on a side of the first rolling-element bearing that faces away from the side surface of the first bearing.

Abstract: A bearing cage has an annular structure with a plurality of pockets defined therein. At least one first surface area of the annular structure is made from, or is coated with, a first material having lipophobic and/or oleophobic properties. A rolling-element bearing includes this bearing cage, a plurality of roller bodies respectively disposed in the pockets, and a lubricant that forms a contact angle of at least 90° when disposed on the first material.

Abstract: A part-bearing-ring of a rolling-element bearing includes first and second assembly bores on its end surface, and the second assembly bore has a larger diameter than the first assembly bore so that it can accommodate a securing sleeve. The second assembly bore may include an internal thread for attaching the securing sleeve. Also a bearing ring formed of two part-bearing-rings and a securing sleeve and a method of installing a bearing ring.

Abstract: A method of mounting a rolling-element bearing support module on a machine having a shaft includes providing a rolling-element bearing support module having a support and a first rolling-element bearing for supporting the shaft, bringing the first rolling-element bearing with the rolling-element bearing support module up to the shaft so that the support abuts the end surface of the machine, rolling the shaft on at least a portion of a circumference of the bore, recording movement data of the shaft during the rolling, determining an alignment point based on the movement data, aligning the rolling-element bearing support module to the alignment point, and affixing the rolling-element bearing support module to the end side of the machine in the aligned position.

Abstract: A bearing having grease lubrication includes a first ring and a second ring. A plurality of screw holes axially extend through the first ring. A first axial end of the first ring is affixed to a housing by a plurality of screws extending from the housing into the respective screw holes. A first bore is defined in the first ring adjacent to a second axial end of the first ring. The first bore intersects and fluidly communicates with one of the screw holes such that grease is dischargeable therethrough.

Abstract: A bearing cage has an annular structure with a plurality of pockets defined therein. At least one first surface area of the annular structure is made from, or is coated with, a first material having lipophobic and/or oleophobic properties. A rolling-element bearing includes this bearing cage, a plurality of roller bodies respectively disposed in the pockets, and a lubricant that forms a contact angle of at least 90° when disposed on the first material.

Abstract: A device for cleaning a surface of a component includes a high voltage source having a cathode configured to be electrically connected with the surface of the component. An ionization electrode includes at least one individual electrode configured to be electrically connected with an anode of the high voltage source. A movable carriage moves the ionization electrode relative to the surface of the component so that an electric field generated between the ionization electrode and the surface of the component is also moved relative to the surface of the component.

Abstract: The invention provides compounds of general formula (I) or a pharmaceutically acceptable salt, polymorph or solvate thereof, including all tautomers and stereoisomers thereof, wherein K, W, X; Y and Z are described throughout the description and claims. The compounds of the present invention are useful as inhibitors of prolyl endopeptidase (PEP, EC 3.4.21.26) and/or IL-6.

Abstract: The present invention provides a method for the treatment of neuronal disorders, in a mammal such as a human, which method comprises administering an effective, non-toxic and pharmaceutically acceptable amount of at least one QC-inhibitor, optionally in combination with at least one agent, selected from the group consisting of PEP-inhibitors, LiCl, inhibitors of DP IV/DP IV-like enzymes, NPY-receptor ligands, NPY agonists, NPY antagonists, ACE-inhibitors, PIMT enhancers, inhibitors of beta secretases, inhibitors of gamma secretases and inhibitors of neutral endopeptidase, to a mammal in need thereof.

Abstract: Inhibitors of prolyl endopeptidase of formula 1 W—KCONH—X—CON—Y—CO—Z??(1) wherein K, W, X, Y and Z are specified in the description. The compounds are useful for the treatment of diseases such as mild cognitive impairment (MCI), Alzheimer's disease, Down Syndrome, Parkinson disease and Chorea Huntington.

Abstract: The present invention relates to novel inhibitors of prolyl endopeptidase of formula 1 W—KCONH—X—CON—Y—CO—Z??(1) wherein K, W, X, Y and Z are specified in the description. The compounds are useful for the treatment of diseases such as mild cognitive impairment (MCI), Alzheimer's disease, Down Syndrome, Parkinson disease and Chorea Huntington.

Abstract: The present invention relates to novel inhibitors of prolyl endopeptidase of formula 1 W—KCONH—X—CON—Y—CO—Z ??(1) wherein K, W, X, Y and Z are specified in the description. The compounds are useful for the treatment of diseases such as mild cognitive impairment (MCI), Alzheimer's disease, Down Syndrome, Parkinson disease and Chorea Huntington.

Abstract: The present invention provides a method for the treatment of neuronal disorders, in a mammal such as a human, which method comprises administering an effective, non-toxic and pharmaceutically acceptable amount of at least one QC-inhibitor, optionally in combination with at least one agent, selected from the group consisting of PEP-inhibitors, LiCl, inhibitors of DP IV/DP IV-like enzymes, NPY-receptor ligands, NPY agonists, NPY antagonists, ACE-inhibitors, PIMT enhancers, inhibitors of beta secretases, inhibitors of gamma secretases and inhibitors of neutral endopeptidase, to a mammal in need thereof.

Abstract: The present invention provides a method for the treatment of neuronal disorders, in a mammal such as a human, which method comprises administering an effective, non-toxic and pharmaceutically acceptable amount of at least one QC-inhibitor, optionally in combination with at least one agent, selected from the group consisting of PEP-inhibitors, inhibitors of DP IV/DP IV-like enzymes, NPY-receptor ligands, NPY agonists, NPY antagonists, ACE-inhibitors, PIMT enhancers, inhibitors of beta secretases, inhibitors of gamma secretases and inhibitors of neutral endopeptidase, to a mammal in need thereof.

Abstract: The present invention discloses a method for the modulation of the enzymatic activity of prolyl endopeptidase in various human tissues and their biological effect on intracellular inositol (1,4,5) triphosphate concentration. The present invention also discloses the potentiation of endogenous neurological and intracellular signaling cascades by inhibition of prolyl endopeptidase activity. This invention further discloses the amplification of substance P mediated stimulation of IP3 concentration by inhibition of proline endopeptidase activity. The effect of reduced PEP activity on second messenger concentration indicates a novel intracellular function of this peptidase, which has an important impact on cognitive enhancements due to PEP inhibition.

Abstract: A friction clutch wherein the clutch spring is shiftable axially toward the pressure plate during disengagement of the clutch to compensate for wear at least upon the friction linings of the clutch disc. Disengagement of the clutch is facilitated by several springs which act upon the clutch spring and upon the pressure plate and render it possible to disengage the clutch in response to the application of a relatively small force to the tips of the radially inwardly extending prongs of the clutch spring. Moreover, the magnitude of the disengaging force remains at least substantially constant during the entire useful life of the clutch.