Patents by Inventor Ingo Uphues

Ingo Uphues has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DOSAGE REGIMEN FOR THE TREATMENT OF NASH
    Publication number: 20240139230
    Abstract: dsRNAi oligonucleotides can be used in methods for the treatment of NASH, preferably the advanced fibrotic and/or cirrhotic stages thereof, using dosage regimens comprising a loading phase followed by a maintenance phase.
    Type: Application
    Filed: October 10, 2023
    Publication date: May 2, 2024
    Inventors: Jens Markus BORGHARDT, Marc ABRAMS, Andre BROERMANN, Bob Dale BROWN, Kevin CRAIG, Henryk T. DUDEK, Saskia ERBEL, Boris FERGER, Felix JOST, Martin Lee KOSER, Jihye PARK, Utsav SAXENA, Bernhard SCHMID, Florian SOMMER, Stephan TENBAUM, Ingo UPHUES
  • Alkyl-containing 5-acylindolinones, the preparation thereof and their use as medicaments
    Patent number: 7560480
    Abstract: The present invention relates to alkyl-containing 5-acylindolinones of general formula wherein R1 to R3 are defined herein, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on protein kinases, particularly an inhibiting effect on the activity of glycogen synthase kinase (GSK-3).
    Type: Grant
    Filed: March 10, 2005
    Date of Patent: July 14, 2009
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Armin Heckel, Gerald Juergen Roth, Joerg Kley, Stefan Hoerer, Ingo Uphues
  • Cycloalkyl—containing 5-acylindolinones, the preparation thereof and their use as medicaments
    Patent number: 7262206
    Abstract: The present invention relates to cycloalkyl-containing 5-acylindolinones of general formula wherein R1 to R3 are defined as in claims 1 to 6, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on protein kinases, particularly an inhibiting effect on the activity of glycogen synthase kinase (GSK-3).
    Type: Grant
    Filed: March 10, 2005
    Date of Patent: August 28, 2007
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Armin Heckel, Gerald Jürgen Roth, Jörg Kley, Stefan Hoerer, Ingo Uphues
  • Aryl-containing 5-acylindolinones, the preparation thereof and their use as medicaments
    Patent number: 7176231
    Abstract: The present invention relates to aryl-containing 5-acylindolinones of general formula wherein R1 to R3 are defined herein, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on protein kinases, particularly an inhibiting effect on the activity of glycogen synthase kinase (GSK-3).
    Type: Grant
    Filed: March 10, 2005
    Date of Patent: February 13, 2007
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Armin Heckel, Gerald Juergen Roth, Joerg Kley, Stefan Hoerer, Ingo Uphues
  • Aryl-containing 5-acylindolinones, the preparation thereof and their use as medicaments
    Publication number: 20050234120
    Abstract: The present invention relates to aryl-containing 5-acylindolinones of general formula wherein R1 to R3 are defined herein, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on protein kinases, particularly an inhibiting effect on the activity of glycogen synthase kinase (GSK-3).
    Type: Application
    Filed: March 10, 2005
    Publication date: October 20, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Armin Heckel, Gerald Roth, Joerg Kley, Stefan Hoerer, Ingo Uphues
  • Alkyl-containing 5-acylindolinones, the preparation thereof and their use as medicaments
    Publication number: 20050209302
    Abstract: The present invention relates to alkyl-containing 5-acylindolinones of general formula wherein R1 to R3 are defined herein, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on protein kinases, particularly an inhibiting effect on the activity of glycogen synthase kinase (GSK-3).
    Type: Application
    Filed: March 10, 2005
    Publication date: September 22, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Armin Heckel, Gerald Roth, Joerg Kley, Stefan Hoerer, Ingo Uphues
  • Cycloalkyl - containing 5-acylindolinones, the preparation thereof and their use as medicaments
    Publication number: 20050203104
    Abstract: The present invention relates to cycloalkyl-containing 5-acylindolinones of general formula wherein R1 to R3 are defined as in claims 1 to 6, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on protein kinases, particularly an inhibiting effect on the activity of glycogen synthase kinase (GSK-3).
    Type: Application
    Filed: March 10, 2005
    Publication date: September 15, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Armin Heckel, Gerald Roth, Joerg Kley, Stefan Hoerer, Ingo Uphues