Abstract: The present disclosure relates to an isolated antibody or antigen-binding fragment thereof that binds to human Sema3A. The isolated antibody or antigen-binding fragment according to the present disclosure i) binds to human Sema3A of the sequence of SEQ ID NO: 600 with a dissociation constant (KD)?50 nM, ?20 nM, ?10 nM, ?1 nM, or ?0.1 nM; ii) cross-reacts with mouse, cynomolgus, rat, pig and/or dog Sema3A, particularly wherein said isolated antibody or antigen-binding fragment thereof binds to mouse, cynomolgus, rat, pig and/or dog Sema3A with a dissociation constant (KD)?50 nM, ?20 nM, ?10 nM, ?1 nM, or ?0.1 nM; iii) binds to human Sema3A of the sequence of SEQ ID NO: 600 with a binding activity as measured by surface plasmon resonance (SPR) of ?60%, ?70%, ?80%, or ?90%; iv) inhibits the activity of human Sema3A of the sequence of SEQ ID NO: 600 in an in vitro mesangial cell migration assay with an EC50 of ?10 nM, ?5 nM, ?2.

Abstract: The disclosure refers to a road construction machine, adapted in particular in the form of a road paver or a feeder vehicle for a road paver. According to the disclosure, the road construction machine comprises a first and/or a second air barrier device adapted to shield a driver and/or an operator of the road construction machine. Furthermore, the disclosure refers to a corresponding method for generating an air flow during operation of a road construction machine in order to shield a driver and/or an operator from vapors and/or aerosols rising during operation of the road construction machine.

Abstract: A device (102) for generating and storing a cryptographic key pair is disclosed. The device comprises a non-persistent memory unit (116) and a processor (114). The processor (114) is configured to receive a plurality of seeds from a respective plurality of users and combine the seeds to define a composite seed. The processor (114) is further configured to generate the key pair, comprising a public key and a private key (104), using the composite seed and a deterministic key generation method, and to record the private key (104) in the non-persistent memory unit (116).

Abstract: A transistor device and a method for forming a transistor device are disclosed. The transistor device includes: first regions of a first doping type and second regions of a second doping type in an inner region and an edge region of a semiconductor body; and transistor cells each having a body region and a source region in the inner region of the semiconductor body. An effective lateral doping dose of the first regions in the edge region is lower than an effective lateral doping dose of the first regions in the inner region. An effective lateral doping dose of the second regions in the edge region is lower than an effective lateral doping dose of the second regions in the inner region.

Abstract: This disclosure relates to analyzing log data of a system. This comprises evaluating a first graph model with multiple log events in the log data. The first graph model comprises a first set of nodes connected by a first set of edges representing a first behaviour. A processor determines a first correspondence value based on the first graph model and indicative of a correspondence between the multiple log events and the first behaviour. The processor repeats the steps of evaluating the first graph model for one or more further graph models representing one or more further behaviors and determining the first correspondence value to determine one or more further correspondence values. The processor finally determines a classification of the multiple log events as representing one of the behaviors based on the correspondence values. The use of multiple graph models allows a more granular classification than binary intrusion detection.

Abstract: Aspects of the invention are directed to characteristics and parameters of color coatings on keratin fibers. The color coatings are produced from compositions of several kinds of polymers that enable the color coatings to exhibit adherence, remanence, wear fastness and resistance to environmental attack.

Abstract: A film coating for keratin fibers is described. The film coating is produced by applying to the keratin fibers a pretreatment composition and a film forming composition and curing the compositions to produce the film coating. The coating may be clear and function as a styling, conditioning and holding. The coating alternatively may contain pigment particles and provide a color coating.

Abstract: In a method for creating at least one low-voltage path of a cell contacting system, where the cell contacting system contains a main body, a guide head having a discharge opening for discharging an electrical conductor is provided. The guide head is guided by a machine in a predefinable path relative to the main body, and the conductor is discharged from the guide head and laid on the main body to form the low-voltage path.

Abstract: The instant disclosure generally relates to a coloring composition for coloring mammalian or synthetic keratin fibers or keratinous surfaces. The composition comprising a medium, optionally pigment microparticles and at least one dye, in particular at least one peri-arylene dye dissolved in the medium. Methods of using such compositions are also described herein.

Abstract: The instant disclosure generally relates to a dual component hair coloring composition for coloring mammalian or synthetic keratin fibers, the composition comprising composition A comprising a cationic polymer, pigment microparticles and an aqueous medium, and comprising composition B comprising an anionic polymer, aqueous medium and optional cross linking agent. Optionally or alternatively composition B may contain pigment particles. The cationic and anionic polymers are at least partially soluble in the medium and the pigment microparticles are dispersed therein. The hair coloring composition forms a dual layer coating upon application to keratin fibers such as hair and has a substantially permanent pigment lastingness following development (setting); minimally alters the keratin fibers, upon application; and substantially eliminates development time. Methods of using such compositions are also described herein.

Abstract: A method for treating hair comprising applying at least one pigment onto hair for providing the basis for colouring hair in a more reproducible and reliable manner independently from a user's initial hair colour.

Abstract: Methods and apparatus for utilising a distributed ledger, such as the Ethereum blockchain, to monitor and execute a process instance (170) between parties that may not trust each other. The proposed methods and apparatus integrate blockchain into the choreography of processes in such a way that no central authority is needed, but trust maintained. The combination of a set of components (a translator 160, a process instance 170 and a trigger/interface 120, 130) allows for monitoring or coordination of business processes on the blockchain (150) and off the blockchain (140).

Abstract: The instant disclosure generally relates to a dual component hair coloring composition for coloring mammalian or synthetic keratin fibers, the composition comprising composition A comprising a cationic polymer, pigment microparticles and an aqueous medium, and comprising composition B comprising an anionic polymer, aqueous medium and optional cross linking agent. Optionally or alternatively composition B may contain pigment particles. The cationic and anionic polymers are at least partially soluble in the medium and the pigment microparticles are dispersed therein. The hair coloring composition forms a dual layer coating upon application to keratin fibers such as hair and has a substantially permanent pigment lastingness following development (setting); minimally alters the keratin fibers, upon application; and substantially eliminates development time. Methods of using such compositions are also described herein.

Abstract: A method for treating hair comprising applying at least one pigment onto hair for providing the basis for colouring hair in a more reproducible and reliable manner independently from a user's initial hair colour.

Abstract: This disclosure relates to analyzing log data of a system. This comprises evaluating a first graph model with multiple log events in the log data. The first graph model comprises a first set of nodes connected by a first set of edges representing a first behaviour. A processor determines a first correspondence value based on the first graph model and indicative of a correspondence between the multiple log events and the first behaviour. The processor repeats the steps of evaluating the first graph model for one or more further graph models representing one or more further behaviors and determining the first correspondence value to determine one or more further correspondence values. The processor finally determines a classification of the multiple log events as representing one of the behaviors based on the correspondence values. The use of multiple graph models allows a more granular classification than binary intrusion detection.

Abstract: The present invention generally relates to an application program interface (API)-controlled computing system (100). A computer-implemented method is proposed for determining undoability of an action to be conducted in the API-controlled computing system (100) represented by a formal domain model. A set of pre-states of the API-controlled computing system (100) for the action are obtained. A set of post-states of the API-controlled computing system (100) corresponding to each pre-state in the set of pre-states for the action are obtained. The method automatically determines if each post-state in each set of post-states of the API-controlled computing system can be undone to its pre-state in the set of pre-states by using a reachability task for the post-state and its pre-state. The action to be conducted in the API-controlled computing system (100) is undoable if each post-state in each set of post-states of the API-controlled computing system (100) can be undone to its pre-state in the set of pre-states.

Abstract: The present invention generally relates to an application program interface (API)-controlled computing system (100). A computer-implemented method is proposed for determining undoability of an action to be conducted in the API-controlled computing system (100) represented by a formal domain model. A set of pre-states of the API-controlled computing system (100) for the action are obtained. A set of post-states of the API-controlled computing system (100) corresponding to each pre-state in the set of pre-states for the action are obtained. The method automatically determines if each post-state in each set of post-states of the API-controlled computing system can be undone to its pre-state in the set of pre-states by using a reachability task for the post-state and its pre-state. The action to be conducted in the API-controlled computing system (100) is undoable if each post-state in each set of post-states of the API-controlled computing system (100) can be undone to its pre-state in the set of pre-states.

Abstract: 1-hexyl-1H-pyrazole-4,5-diamine hemisulfate, as represented in formula (IX-a), and its use in oxidative dyeing composition. This pyrazole salt was found to combine good stability as raw material and good shade intensity with a range of common couplers when formulated in hair dyeing composition.

Abstract: In computer-implemented methods to validate process models, the models carry semantic information that is related to the process steps, including pre-conditions that indicate whether a step would be executable under certain conditions and post-conditions relating to results from executing a step. Steps are related as predecessor/successor so that a post-condition of the predecessor step can be the pre-condition of a successor step. During model validation, variables are exchanged and propagated between the step conditions. Instead of validating the model for potentially all initial values of variables and conditions, the system identifies portions of the model that can be validated separately for a reduced set of initial states.

Abstract: 1-hexyl-1H-pyrazole-4,5-diamine hemisulfate, as represented in formula (IX-a), and its use in oxidative dyeing composition. This pyrazole salt was found to combine good stability as raw material and good shade intensity with a range of common couplers when formulated in hair dyeing composition.