Abstract: This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt thereof, or an N-oxide thereof), which are positive allosteric modulators of one or more GABA-A receptors, e.g., which are peripherally restricted, positive allosteric modulators of one or more GABA-A receptors; e.g., which are positive allosteric modulators of one or more GABA-A receptors and which selectively target the peripheral nervous system and organs of the body, and which do not substantially pass through the blood-brain barrier. Said compounds are useful e.g., for the treatment of systemic diseases of the body, e.g., diseases in which modulation of one or more peripherally restricted GABA-A receptors is beneficial (e.g., diseases or disorders which are mediated by GABA-A neuronal activity. This disclosure also features pharmaceutical compositions containing the chemical entities described herein as well as methods of using same for the treatment of systemic diseases of the body.

Abstract: Compounds are described which inhibit mitogen activated protein kinase-activated protein kinase-2 (MK-2). Methods of making such compounds are described, as well as a method of using them for the inhibition of MK-2, and for the prevention or treatment of a disease or disorder that is mediated by TNF?, where the method involves administering to the subject an MK-2 inhibiting compound of the present invention. Pharmaceutical compositions and kits which contain the present MK-2 inhibiting compounds are also described.

Abstract: A method is described for inhibiting mitogen activated protein kinase-activated protein kinase-2 in a subject in need of such inhibition, where the method involves administering to the subject a beta-carboline MK-2 inhibiting compound, or a pharmaceutically acceptable salt thereof.

Abstract: The present invention provides novel bridged beta-carboline compounds that are capable of inhibiting mitogen activated protein kinase-activated protein kinase-2 and analogues thereof and pharmaceutical compositions and kits that include these compounds.

Abstract: A foldable letter that can be mailed. The latter encompasses a cut-out paper sheet, one surface of which is intended to receive communications or messages, and the other side of which is intended to receive postal indications, i.e., an address. This letter solves the double problem of finding a form that encourages the writing of letters in the face of the progression of electronic communication equipment and, on the other hand, of enabling easy opening of a folded and sealed letter without tearing it. The proposed solution relates to an appropriate carrier for handwritten communications, and a closure technique offering to the receiver an acceptable letter in its original size. The letter has a square basic shape and includes a rectangular field, the long sides of which are parallel, but not symmetrical, to one of the diagonals of the square.

Abstract: A letter whose letter card consists of one or more plates of hard-paste china bearing one or more messages in the form of images, handwritten notes, proverbs, verses or the like. The envelope for the letter card consists of relatively stiff and shock-absorbent material, such as corrugated cardboard. Prior to introduction into the envelope, the letter card is placed into a recess formed in one side of an insert which snugly fits into the envelope and is also made of corrugated cardboard. The letter card can be assembled of two plates which are pivotally connected to each other by one or more flexible strips so that they can pivot relative to each other between first positions of full overlap and second positions in which they are located in mutually inclined planes. The letter card can be placed on a table top, suspended on a wall, framed or otherwise set up for more or less permanent exhibition in a home, office, dormitory, military barracks or the like.

Abstract: A letter whose letter card consists of one or more plates of hard-paste china bearing one or more messages in the form of images, handwritten notes, proverbs, verses or the like. The envelope for the letter card consists of relatively stiff and shock-absorbent material, such as corrugated cardboard. Prior to introduction into the envelope, the letter card is placed into a recess formed in one side of an insert which snugly fits into the envelope and is also made of corrugated cardboard or a like shock-absorbent material to reduce the likelihood of chipping, breakage and/or other damage to the letter card during mailing or other mode of shipment to the recipient(s). The letter card can be assembled of two plates which are pivotally connected to each other by one or more flexible strips so that they can pivot relative to each other between first positions of full overlap preparatory to introduction into the envelope and second positions in which they are located in mutually inclined planes.