Abstract: The present invention relates to the design of trimeric polypeptides using polypeptide structural elements derived from the tetranectin protein family, and their use in rational de novo design and production of multi-functional molecules including the application of the multi-functional molecules in protein library technology, such as phage display technology, diagnostic and therapeutic systems, such as human gene therapy and imaging. The trimeric polypeptides being constructed as a monomer polypeptide construct comprising at least one tetranectin trimerising structural element (TTSE) which is covalently linked to at least one heterologous moiety, said TTSE being capable of forming a stable complex with two other TTSEs; or as an oligomer which is comprised of two monomer polypeptide constructs as mentioned above, and which comprises three TTSEs or a multiplum of three TTSEs, or which is comprised of three monomer polypeptide constructs.

Abstract: An article for conditioning fibrous materials includes a dispensing container of liquid fabric conditioning composition which has an opening in the wall thereof through which the conditioning composition is gradually dispensed into contact with fibrous materials to be conditioned. The conditioning composition is usually an aqueous solution of a surface active synthetic organic anionic, nonionic or cationic fabric conditioning agent, which is a softening agent that usually also makes the treated fabrics non-static. The container of conditioning composition usually includes a plurality of small dispensing openings therein and the viscosity of the solution of conditioning agent may be such that dispensing is preventable until the container comes into contact with materials to be treated or is subjected to shocks, as in tumbling of the container in contact with laundry being dried in an automatic laundry dryer.