Abstract: Chemical substances having selective adrenal toxicity for use in medicine, especially for treatment of adrenocortical hypersecretion and tumour growth.

Abstract: The present invention relates to novel treatment of adrenocortical hypersecretion. More specifically, the present invention relates to chemical substances having selective adrenal toxicity for use in medicine, especially for treatment of adrenocortical hypersecretion and tumour growth. For this purpose the present invention provides a compound having the following formula for use in medicine, especially human medicine wherein the first phenyl ring comprises one or more substituents R1 which is halogen (F, CI, Br or I), preferably in position 4; R2 and R3 are halogen, A is a single or double bond between the side chain carbon atoms; the second phenyl ring comprises an electrophilic group R4, preferably in position 3, which is SO2R5 or its metabolic precursors S R5 and SOR5, NO2 or CF3 where R5 is H or a lower alkyl, especially CH3; and one or more substituents R6 which is halogen (F, Cl, Br or I), preferably in position 4.