Patents by Inventor Inn-Ho Tsai

Inn-Ho Tsai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heparin/heparan sulfate-dependent inhibitors of activated protein C and uses thereof in treating hemophilic disorders
    Patent number: 9206246
    Abstract: Methods for inhibiting activated protein C (APC) comprising contacting the APC with a Kunitz polypeptide in an amount effective in inhibiting the activity of APC, wherein the Kunitz polypeptide comprises six cysteine residues at positions corresponding to positions 7, 16, 32, 40, 53, and 57 in SEQ ID NO:1, a motif X1GX2CBX? at positions corresponding to positions 13-18 in SEQ ID NO:1, wherein each of X1 and X2, independently, is any amino acid residue, B is a basic amino acid residue, and X? is G, A, or V; and at least one heparin-binding motif, which can present at the C-terminus of the Kunitz polypeptide.
    Type: Grant
    Filed: November 15, 2013
    Date of Patent: December 8, 2015
    Assignee: Academia Sinica
    Inventors: Inn-Ho Tsai, An-Chun Cheng
  • Heparin/Heparan Sulfate-Dependent Inhibitors of Activated Protein C and Uses Thereof in Treating Hemophilic Disorders
    Publication number: 20140142040
    Abstract: Methods for inhibiting activated protein C (APC) comprising contacting the APC with a Kunitz polypeptide in an amount effective in inhibiting the activity of APC, wherein the Kunitz polypeptide comprises six cysteine residues at positions corresponding to positions 7, 16, 32, 40, 53, and 57 in SEQ ID NO:1, a motif X1GX2CBX? at positions corresponding to positions 13-18 in SEQ ID NO:1, wherein each of X1 and X2, independently, is any amino acid residue, B is a basic amino acid residue, and X? is G, A, or V; and at least one heparin-binding motif, which can present at the C-terminus of the Kunitz polypeptide.
    Type: Application
    Filed: November 15, 2013
    Publication date: May 22, 2014
    Inventors: Inn-Ho Tsai, An-Chun Cheng