Abstract: The implantable medical devices are configured to release at least one therapeutic agent from a matrix affixed to the implantable body with a release profile which is programmable to the agent and treatment. The matrix is formed such that the concentration of the therapeutic agent in the matrix varies as a gradient relative to a surface of the implantable body. The change in the concentration gradient of the agent in the matrix directly controls the rate of elution of the agent from the matrix. The therapeutic agent matrix can be disposed in the stent or on surfaces of the stent in various configurations, including within volumes defined by the stent, such as openings, holes, or concave surfaces, as a reservoir of agent, and alternatively as a coating on all or a portion of the surfaces of the stent structure.

Abstract: The present invention relates to method for loading a beneficial agent into an expandable medical device. The method includes the steps of sealing a plurality of openings extending through the medical device from a first side to a second side with a sealing member to substantially prevent a beneficial agent from passing through the openings, partially filling the openings with the beneficial agent delivered from an automated micro-jetting dispenser, substantially solidifying the beneficial agent, and removing the sealing member from the plurality of openings.