Patents by Inventor Institut National de la Sante et de la Recherche

Institut National de la Sante et de la Recherche has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SPINAL MUSCULAR ATROPHY DIAGNOSTIC METHODS
    Publication number: 20130323759
    Abstract: The present invention relates to the discovery of the human survival motor-neuron gene or SMD gene, which is a chromosome 5-SMA (Spinal Muscular Atrophy) determining gene. The present invention further relates to the nucleotide sequence encoding the SMN gene and corresponding amino acid sequence, a vector containing the gene encoding the SMN protein or a DNA sequence corresponding to the gene and transformant strains containing the SMN gene or a DNA sequence corresponding to the gene.
    Type: Application
    Filed: February 4, 2013
    Publication date: December 5, 2013
    Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
    Inventor: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
  • IDENTIFICATION OF A JAK2 MUTATION INVOLVED IN VAQUEZ POLYGLOBULIA
    Publication number: 20130189683
    Abstract: The present invention concerns the V617F variant of the protein-tyrosine kinase JAK2, said variant being responsible for Vaquez Polyglobulia. The invention also relates to a first intention diagnostic method for erythrocytosis and thrombocytosis allowing their association with myeloproliferative disorders, or to the detection of the JAK2 V617F variant in myeloproliferative disorders allowing their reclassification in a new nosological group.
    Type: Application
    Filed: February 15, 2013
    Publication date: July 25, 2013
    Applicants: ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS, IGR&D SA, UNIVERSITE PARIS-SUD, INSTITUT GUSTAVE-ROUSSY, UNIVERSITE DE VERSAILLES - ST QUENTIN EN YVELINES, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Assistance Publique - Hopitaux De Paris, IGR&D SA, Institut National De La Sante Et De La Recherche Medicale (INSERM), Institut Gustave-Roussy, Universite De Versailles - St Quentin En Yvelines, Universite Paris-Sud
  • LENTIVIRAL VECTORS FOR THE PREPARATION OF IMMUNOTHERAPEUTICAL COMPOSITIONS
    Publication number: 20130157357
    Abstract: The invention relates to an immunogenic composition comprising a recombinant vector characterized in that it comprises a polynucleotide comprising the cis-acting central initiation region (cPPT) and the cis-acting termination region (CTS), these regions being of retroviral or retroviral-like origin, said vector comprising in addition a defined nucleotide sequence (transgene or sequence of interest) and regulatory signals of retrotranscription, expression and encapsidation of retroviral or retroviral-like origin, wherein the composition is capable of inducing or of stimulating a cell-mediated response for instance a CTL (Cytotoxic T Lymphocytes) response or a CD4 response, against one or several epitopes encoded by the transgene sequence present in the vector.
    Type: Application
    Filed: December 12, 2012
    Publication date: June 20, 2013
    Applicants: INSTITUT PASTEUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
    Inventors: INSTITUT PASTEUR, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, CENTRE NATIONAL DE LA RECHERCHE SCIEN
  • Diagnosis of Hereditary Spastic Paraplegias (HSP) by Identification of a Mutation in the ZFVYE26 Gene or Protein
    Publication number: 20130137096
    Abstract: The Invention relates to an ex vivo method of diagnosing or predicting a hereditary spastic paraplegias (HSP), in a subject, which method comprises detecting a mutation in the ZFYVE26 gene or protein (spastizin), wherein said mutation is indicative of a hereditary spastic paraplegias (HSP).
    Type: Application
    Filed: October 31, 2012
    Publication date: May 30, 2013
    Applicant: Institut National de la Sante et de la Recherche Medical (INSERM)
    Inventor: Institut National de la Sante et de la Recherche
  • SERINE PROTEASE DERIVATIVES AND USES IN THE PREVENTION OR THE TREATMENT OF BLOOD COAGULATION DISORDERS
    Publication number: 20130101570
    Abstract: The present invention relates to chimeric derivatives of serine protease zymogen containing the activation peptide of factor X or a fragment thereof for improving the half-life of said derivatives. Preferably, said chimeric derivatives are protein C and factor X derivatives. The invention also relates to said derivatives for the prevention or treatment of blood coagulation disorders.
    Type: Application
    Filed: January 2, 2013
    Publication date: April 25, 2013
    Applicant: Institut National de la Sante et de la Recherche Mediclae (INSERM)
    Inventor: Institut National de la Sante et de la Recherche Medicale (INSERM)