Abstract: A method of masking the off-taste of an artificial or natural sweetener, comprising the addition to the sweetener of at least one compound according to the formula I in which R1 is selected from H, C1-C4 alkyl and Ph: R2 is selected from H and Me: R3 is selected from H, C1-C4 alkyl and Ph: R4 is selected from H and C1-C4 alkyl: or R3, R4 together form a five, six or seven-membered aliphatic ring.

Abstract: Sucralose-binding TAS2R bitter taste receptors have been identified. Novel methods to identify modulators and in particular inhibitors to the bitter taste of sucralose and an inhibitor, are provided.

Abstract: A method of making a compound of formula II comprising the reaction of a compound of formula RCONH2 with a compound of formula III R being a moiety having between 1 and 15 carbon atoms and optionally from 1 to 5 heteroatoms independently selected from oxygen, nitrogen and sulfur, and X and Y being independently selected front the group consisting of H, methyl, ethyl, OMe, OEt, and mixtures thereof; the reaction being performed in a solvent in the presence of a base. The method is useful for the inexpensive manufacture of certain commercially-valuable compounds, including some that have desirable cooling properties.