Patents by Inventor Ioana R. Simion, legal representative

Ioana R. Simion, legal representative has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process and methods for the preparation of optically active cis-2-hydroxymethyl-4- (cytosin-1'-yl)-1,3-oxathiolane or pharmaceutically acceptable salts thereof
    Patent number: 7968703
    Abstract: There is provided a method for resolving a compound of formula III, in the cis configuration: There is also provided a process for producing optically active compound of formula I or II: wherein: R1, R2, R3 are as defined herein, the method and process involving the production, recovery and conversion of diastereomeric salts.
    Type: Grant
    Filed: March 7, 2005
    Date of Patent: June 28, 2011
    Assignee: SHIRE Canada Inc.
    Inventors: Alex Cimpoia, Dan Simion, Ioana R. Simion, legal representative
  • Enantiomeric resolution of 2-substituted 4-substituted 1,3-oxathiolanes nucleosides
    Patent number: 7501514
    Abstract: Single enantionmers of compounds of formula (B), in either the cis or trans configuration, wherein R1 and R2 are as defined herein, can be separated from enantiomeric mixtures thereof by reacting the compound with an acid to produce a conglomerate salt that has the following characteristics: the IR spectrum of the salt of the racemic compound, a 1:1 mixture of (?) and (+) crystals, is identical to that of the each of the single enantiomer, and the salt of the racemic compound has a melting point lower that that of either single enantiomer. The conglomerate salt is then separated by preferential crystallization.
    Type: Grant
    Filed: October 15, 2004
    Date of Patent: March 10, 2009
    Assignee: Shire Biochem, Inc.
    Inventors: Dragos Vizitiu, Ioana R. Simion, legal representative, Jean-Eric Lacoste, Dan Simion