Patents by Inventor Ioannis C. Tomazos

Ioannis C. Tomazos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR IDENTIFYING THE HEALTH STATE OF HYPOPHOSPHATASIA (HPP) PATIENTS
    Publication number: 20200121767
    Abstract: The disclosure features methods for identifying the health state of patients having hypophosphatasia (HPP). The health state of the patient, once identified, can be used to, e.g., assign a treatment regimen featuring the administration of a soluble alkaline phosphatase (sALP) to the patient, to monitor the efficacy of the treatment regimen, and/or to modify the treatment regimen. The methods also include assessing the transition of a patient with HPP from one health state to another, e.g., after completion of a treatment regimen that includes administering an sALP.
    Type: Application
    Filed: April 10, 2018
    Publication date: April 23, 2020
    Applicant: Alexion Pharmaceuticals, Inc.
    Inventors: Ioannis C. TOMAZOS, Andrew LLOYD
  • Biosensor for continuous monitoring of metabolites and proteins and methods of manufacture thereof
    Patent number: 8608922
    Abstract: A biosensor comprises a substrate; a reference electrode; a working electrode; a counter electrode; and a plurality of permeability adjusting spacers. The reference electrode, the working electrode and the plurality of permeability adjusting spacers are all being disposed to be substantially parallel to each other to create a plurality of enzyme containing porous sections. The enzyme containing porous sections contain an enzyme; where the enzyme is operative to react with a metabolite to determine the concentration of the metabolite. By combining a number of the aforementioned biosensors, the differential concentration of a target enzyme or protein is determined by monitoring the changes on its metabolite substrates.
    Type: Grant
    Filed: November 9, 2009
    Date of Patent: December 17, 2013
    Assignee: The University of Connecticut
    Inventors: Fotios Papadimitrakopoulos, Santhisagar Vaddiraju, Faquir Chand Jain, Ioannis C. Tomazos
  • BIOSENSOR FOR CONTINUOUS MONITORING OF METABOLITES AND PROTEINS AND METHODS OF MANUFACTURE THEREOF
    Publication number: 20100116691
    Abstract: A biosensor comprises a substrate; a reference electrode; a working electrode; a counter electrode; and a plurality of permeability adjusting spacers. The reference electrode, the working electrode and the plurality of permeability adjusting spacers are all being disposed to be substantially parallel to each other to create a plurality of enzyme containing porous sections. The enzyme containing porous sections contain an enzyme; where the enzyme is operative to react with a metabolite to determine the concentration of the metabolite. By combining a number of the aforementioned biosensors, the differential concentration of a target enzyme or protein is determined by monitoring the changes on its metabolite substrates.
    Type: Application
    Filed: November 9, 2009
    Publication date: May 13, 2010
    Applicant: UNIVERSITY OF CONNECTICUT
    Inventors: Fotios Papadimitrakopoulos, Santhisagar Vaddiraju, Faquir Chand Jain, Ioannis C. Tomazos