Patents by Inventor Ioannis Houpis

Ioannis Houpis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diastereoselective preparation of Michael adducts
    Patent number: 6479672
    Abstract: Michael addition conducted in the presence of a zinc-amine complex and additional amounts of the amine component results in product with high diastereomeric excess.
    Type: Grant
    Filed: April 7, 2000
    Date of Patent: November 12, 2002
    Assignees: Merck & Co., Inc., Banyu Pharmaceutical Co., Ltd,
    Inventors: Ioannis Houpis, Ralph P. Volante, Fengrui Lang, Ilias Dorziotis, David Tschaen, Shinji Kato, Toshiaki Mase
  • Process for the preparation of arylamines
    Publication number: 20010047013
    Abstract: Arylamines are prepared from aryl halides/methanesulfonates using ammonia and copper reagent under mild reaction conditions.
    Type: Application
    Filed: March 5, 2001
    Publication date: November 29, 2001
    Inventors: Fengrui Lang, Ioannis Houpis
  • Process for making phenyl heterocycles useful as COX-2 inhibitors
    Patent number: 6080876
    Abstract: The invention encompasses a process for making compounds of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases.
    Type: Grant
    Filed: September 17, 1998
    Date of Patent: June 27, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Ilias Dorziotis, Ioannis Houpis, Kan K. Eng
  • Convergent process for the preparation of a growth hormone secretagogue
    Patent number: 6046333
    Abstract: The present invention is directed to a novel convergent process for the preparation of the compound N-[1(R)-[(1,2-dihydro-1-methanesulfonyl-spiro[3H-indole-3,4'-piperdin]-1'- yl)carbonyl]-2-(phenylmethyl-oxy)ethyl]-2-amino-2-methyl-propanamide, and salts thereof, which has the structure: ##STR1## and which has the ability to stimulate the release of natural or endogenous growth hormone. This compound may be used to treat conditions which require the stimulation of growth hormone production or secretion such as in humans with a deficiency of natural growth hormone or in animals used for food or wool production where the stimulation of growth hormone will result in a larger, more productive animal.
    Type: Grant
    Filed: October 21, 1997
    Date of Patent: April 4, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Ilias Dorziotis, Ioannis Houpis, Audrey Molina, Ralph Volante
  • Process for the preparation of a growth hormone secretagogue
    Patent number: 6028196
    Abstract: The present invention is directed to a novel process for the preparation of the compound N-[1(R)-[(1,2-dihydro-1-methanesulfonyl-spiro[3H-indole-3,4'-piperdin]-1'- yl)carbonyl]-2-(phenylmethyl-oxy)ethyl]-2-amino-2-methyl-propanamide, and salts thereof, which has the structure: ##STR1## and which has the ability to stimulate the release of natural or endogenous growth hormone. This compound may be used to treat conditions which require the stimulation of growth hormone production or secretion such as in humans with a deficiency of natural growth hormone or in animals used for food or wool production where the stimulation of growth hormone will result in a larger, more productive animal.
    Type: Grant
    Filed: April 22, 1998
    Date of Patent: February 22, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Peter Houghton, Ioannis Houpis, Audrey Molina, Joseph Lynch, Ralph Volante
  • Method of preparing phosphodiesterase IV inhibitors
    Patent number: 5728838
    Abstract: A process for the preparation of a compound of structural formula I ##STR1## wherein R.sup.1 is alkyl, alkenyl, phenyl or substituted phenyl, which comprises the addition of R.sup.1 to an intermediate 2: ##STR2## by treatment of 2 with (R.sup.1).sub.3 M followed by reductive removal of the sulfinyl group.
    Type: Grant
    Filed: April 2, 1997
    Date of Patent: March 17, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Ioannis Houpis, Audrey Molina, Ralph P. Volante
  • Method of synthesizing furo[2,3-b]pyridine carboxylic acid esters
    Patent number: 5489685
    Abstract: A process is disclosed for rapid synthesis of substituted furanyl pyridines.
    Type: Grant
    Filed: May 12, 1994
    Date of Patent: February 6, 1996
    Assignee: Merck & Co., Ltd.
    Inventors: Ioannis Houpis, Audrey Molina, Joseph E. Lynch, Hywyn R. O. Churchill, Ralph P. Volante, Paul J. Reider, Woo-Baeg Choi
  • Process for the preparation of 4-chloro-2-cyclopropylcarbonylaniline
    Patent number: 5426230
    Abstract: 4-Chloro-2-cyclopropylcarbonylaniline is prepared by condensation of 4-chloroaniline with 4-chlorobutyronitrile to form a 2-(4-chlorobutyryl)-4-chloroaniline, followed by ring closure of the 4-chlorobutyryl group to a cyclopropylcarbonyl moiety.
    Type: Grant
    Filed: June 10, 1994
    Date of Patent: June 20, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Alan Douglas, Ioannis Houpis, Audrey Molina, Ralph P. Volante, Nobuyoshi Yasuda
  • Facile condensation of methylbenzoxazoles with aromatic aldehydes
    Patent number: 5290941
    Abstract: An efficient process for the preparation of styrylbenzoxazoles and derivatives thereof comprises reacting a methylbenzoxazole with an aromatic aldehyde in the presence of strong base at low temperature, followed by warming. The condensation products are inhibitors of H.sup.+ K.sup.+ -ATPase, and are also useful as penultimate compounds in the preparation of inhibitors of HIV reverse transcriptase.
    Type: Grant
    Filed: October 14, 1992
    Date of Patent: March 1, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Ralph P. Volante, Joseph E. Lynch, Ioannis Houpis, Audrey Molina