Patents by Inventor Ioannis I. Valvis

Ioannis I. Valvis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation of asymmetric cyclic ureas through a monoacylated diamine intermediate
    Patent number: 6452000
    Abstract: The present invention concerns an improved process for the preparation of asymmetric cyclic ureas as well as intermediates in the preparation of asymmetric cyclic ureas. In the process, a diamine of formula (I-a) is selectively monoacylated to give an asymmetric monoacylated diamine which can be converted into asymmetric intermediates. The asymmetric intermediates can be further alkylated, cyclized, and/or modified to give compounds which are useful as HIV protease inhibitors for the treatment of HIV infection. The invention allows for scalable preparation of a wide variety of asymmetrical cyclic ureas.
    Type: Grant
    Filed: March 7, 2001
    Date of Patent: September 17, 2002
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Benjamin R. P. Stone, Luigi Anzalone, Joseph M. Fortunak, Gregory D. Harris, Ioannis I. Valvis, Robert E. Waltermire
  • Preparation of asymmetric cyclic ureas through a monoacylated diamine intermeidate
    Publication number: 20010020093
    Abstract: The present invention concerns an improved process for the preparation of asymmetric cyclic ureas as well as intermediates in the preparation of asymmetric cyclic ureas.
    Type: Application
    Filed: March 7, 2001
    Publication date: September 6, 2001
    Inventors: Benjamin R. Stone, Luigi Anzalone, Joseph M. Fortunak, Gregory D. Harris, Ioannis I. Valvis, Robert E. Waltermire
  • Preparation of asymmetric cyclic ureas through a monoacylated diamine intermediate
    Patent number: 6218534
    Abstract: A process for the preparation of asymmetric cyclic ureas of Formula (VI) starting from the diamine of Formula (I).
    Type: Grant
    Filed: October 5, 1998
    Date of Patent: April 17, 2001
    Assignee: Dupont Pharmaceuticals Company
    Inventors: Benjamin R. P. Stone, Luigi Anzalone, Joseph M. Fortunak, Gregory D. Harris, Ioannis I. Valvis, Robert E. Waltermire