Abstract: In accordance with embodiments of this disclosure, a computational simulation platform for assessing impact of coronary artery bypass grafting comprises a computer-implemented method that includes: generating patient-specific three-dimensional (3D) reconstructions of path lines for a patient's heart, ascending aorta, aortic arch, descending thoracic aorta, great vessels, coronary arteries and their major branches based on noninvasive imaging; performing virtual CABG by modifying the patient-specific 3D reconstructions to computationally add path lines for one or more bypass grafts; performing post-virtual CABG computational fluid dynamic (CFD) studies under computational resting and stress conditions; and assessing hemodynamic impact of virtual CABG on the resting and hyperemic flow of diseased native coronary arteries and virtual bypass grafts.

Abstract: In accordance with embodiments of this disclosure, a computational simulation platform comprises a computer-implemented method that includes: generating a mesh or meshless three-dimensional (3D) reconstruction of a vessel lumen and a surface of the vessel lumen based on invasive or non-invasive imaging; assigning material properties to the 3D reconstructed surface of the vessel lumen based on the invasive or non-invasive imaging; performing balloon pre-dilation, stenting and balloon post-dilation computational simulations with the 3D reconstructed vessel lumen and surface of the vessel lumen; and assessing stent and vessel morphometric and biomechanical measures based on the computational simulations.

Abstract: In accordance with embodiments of this disclosure, a computational simulation platform comprises a computer-implemented method that includes: generating a three-dimensional (3D) reconstruction of a vessel lumen and a surface of the vessel lumen based on invasive or non-invasive imaging; generating a mesh of the 3D reconstructed vessel lumen and surface of the vessel lumen; assigning material properties to the 3D reconstructed surface of the vessel lumen; importing design and material properties of stents and balloons; generating a mesh of a stent and balloon; positioning the meshed stent and balloon within the mesh of the 3D reconstructed vessel lumen and surface of the vessel lumen; performing balloon pre-dilation, stenting and balloon post-dilation computational simulations with the mesh of the 3D reconstructed vessel lumen and surface of the vessel lumen; and assessing stent and vessel morphometric and biomechanical measures based on the computational simulations.

Abstract: In accordance with embodiments of this disclosure, a computational simulation platform comprises a computer-implemented method that includes: generating a three-dimensional (3D) reconstruction of a vessel lumen and a surface of the vessel lumen based on invasive or non-invasive imaging; generating a mesh of the 3D reconstructed vessel lumen and surface of the vessel lumen; assigning material properties to the 3D reconstructed surface of the vessel lumen; importing design and material properties of stents and balloons; generating a mesh of a stent and balloon; positioning the meshed stent and balloon within the mesh of the 3D reconstructed vessel lumen and surface of the vessel lumen; performing balloon pre-dilation, stenting and balloon post-dilation computational simulations with the mesh of the 3D reconstructed vessel lumen and surface of the vessel lumen; and assessing stent and vessel morphometric and biomechanical measures based on the computational simulations.

Abstract: A catheter for atraumatic delivery of fluid is disclosed. In embodiments, the catheter includes a catheter shaft with a guidewire lumen disposed within the catheter shaft and an infusion lumen at least partially defined by the catheter shaft. The infusion lumen may at least partially surround the guidewire lumen. The catheter shaft includes a plurality of pores extending through an outer surface of the catheter shaft to the infusion lumen. The plurality of pores are disposed near a distal end of the catheter shaft and are configured to radially dispense a fluid from the infusion lumen.