Abstract: In certain aspects, the disclosure relates to devices and methods for treating wounds wherein an acetylcholinesterase inhibitor is delivered to a wound to promote wound healing. In further aspects, metrifonate can be delivered to the wound by time release from a wound dressing. In further aspects a sequence of wound dressings can be applied to the wound to treat different phases of wound healing.

Abstract: In certain aspects, the disclosure relates to a recombinant nucleic acid molecule (e.g. RNA molecule) encoding one or more polypeptides selected from the group consisting of chitinase-3-like protein 1 (CHI3L1), a fibroblast growth factor (FGF), interleukin-2 ORF7 (IL-2 ORF7), interleukin-2 (IL-2), an interleukin-17 (IL-17) protein, and an IL-17 receptor, wherein the recombinant RNA molecule comprises at least one chemical modification. Cells, pharmaceutical compositions and wound dressings comprising one or more of the recombinant nucleic acid molecules are also disclosed. Methods of promoting wound healing in a subject are further disclosed.

Abstract: A system is configured to provide guided interfaces and support for users throughout the process of abandoning an oil or gas well, and to create and issue carbon credits corresponding to the abandonment upon completion of the project. The system architecture is configured to ensure that carbon credits issued from the system are transparent and auditable, and that underlying support for the credits is accurate and supports the additionality and permanence of the project. Project information and documentation is stored on a public blockchain and distributed file system to ensure immutability and availability of the records. Carbon credits from a completed project are issued as tokens or other digital assets that may be exchanged between parties, and retired for reporting and emission offset purposes. Each token minted by the system links back to a specific project on the blockchain, allowing for public review of all supporting information and documentation.

Abstract: Provided herein are neural interface systems for a patient, the systems comprising an implantable sensor device and an external processing device. The implantable sensor device comprises: an implantable lead assembly for implantation above the skull and below the skin of the patient, and for recording physiologic parameter information of the patient; and an implantable transmitter for receiving the physiologic parameter information from the implantable lead assembly and for transmitting patient data that is based on the physiologic parameter information. The external processing device receives the patient data from the implantable transmitter. Methods of provided a neural interface are also described.

Abstract: A method for determining an increased risk of death of a patient includes receiving ECG data of the patient generated during a first time period; receiving EEG data of the patient generated during the first time period; composing a feature of the ECG data and a feature of the EEG data over a common time frame and determining a statistical measure of association between the ECG data and the EEG data; and determining whether the degree of association exceeds a predetermined threshold, thereby indicating whether an increased risk is present.

Abstract: A method for determining an increased risk of death of a patient includes receiving ECG data of the patient generated during a first time period; receiving EEG data of the patient generated during the first time period; composing a feature of the ECG data and a feature of the EEG data over a common time frame and determining a statistical measure of association between the ECG data and the EEG data; and determining whether the degree of association exceeds a predetermined threshold, thereby indicating whether an increased risk is present.

Abstract: One aspect of the present disclosure relates to a system that can identify a focal area of abnormal brain interactions in a subject. Time series data can be received that corresponds to recordings from a plurality of regions in a brain of the subject during a resting period. Based on the time series data, an information inflow associated with each of the plurality of regions can be determined. The focal area of the abnormal brain interactions can be identified as one of the plurality of regions having a maximum information inflow.

Abstract: One aspect of the present disclosure relates to a system that can identify a focal area of abnormal brain interactions in a subject. Time series data can be received that corresponds to recordings from a plurality of regions in a brain of the subject during a resting period. Based on the time series data, an information inflow associated with each of the plurality of regions can be determined. The focal area of the abnormal brain interactions can be identified as one of the plurality of regions having a maximum information inflow.

Abstract: An implant meant for hip resurfacing arthroplasty, a surgical reconstruction performed on patients with diseased hips, during which the surgeon replaces the surface of the femoral head with a polished metallic hemispherical shell is disclosed. The implant includes a metallic shell with a polished hemispherical outer surface and an inner hemispherical concave surface, from which extends a trunnion having internal threads and thin meridian fins. The inner concave surface of the implant is fully metal porous coated for osseointegration between implant and bone. The presented implant is fitted onto the appropriately contoured femoral head and is stabilized by means of a preload tension wire which drills the femoral head and neck and exits the greater trochanter. The wire attaches proximally to the thread of the trunnion of the shell and distally to a nut-washer combination, by the tightening of which establishment of preload is achieved.

Abstract: The presented invention is an implant meant for hip resurfacing arthroplasty, a surgical reconstruction performed on patients with diseased hips, during which the surgeon replaces the surface of the femoral head with a polished metallic spherical shell. The presented implant consists of a metallic shell (1) with a polished hemispherical outer surface and an inner hemispherical concave surface, which possesses a trunnion (2) with a thread (4) and thin meridian fins (3) and is fully metal porous coated for osseointegration between implant and bone. The presented implant is fitted onto the appropriately contoured femoral head and is stabilized by means of a preload tension wire (5), which drills the femoral head and neck and exits the greater trochanter. The wire attaches proximally to the thread (4) of the trunnion (2) of the shell and distally to a nut-washer combination (6), by the tightening of which establishment of preload is achieved.