Patents by Inventor Ioav Zvi Cabantchik

Ioav Zvi Cabantchik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for detecting non-transferrin bound iron
    Patent number: 9291619
    Abstract: A method of quantifying non-transferrin bound iron (NTBI) in a biological fluid is provided, the method comprising: (a) contacting a sample of the biological fluid with a reducing agent to obtain redox-active iron; (b) contacting the sample of the biological fluid with a nitrilotriacetate (NTA) at a concentration of 0.4-2 mM to mobilize non-transferrin bound iron including redox inactive and the redox active iron in the sample; (c) contacting the sample of the biological fluid of step (b) with an indicator including an iron binding moiety and fluorophore; and (d) detecting and quantifying a fluorescent signal of the fluorophore thereby quantifying the NTBI in the biological sample.
    Type: Grant
    Filed: October 4, 2012
    Date of Patent: March 22, 2016
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Ioav Zvi Cabantchik, William Breuer
  • METHOD FOR DETECTING NON-TRANSFERRIN BOUND IRON
    Publication number: 20130203800
    Abstract: A method of quantifying non-transferrin bound iron (NTBI) in a biological fluid is provided, the method comprising: (a) contacting a sample of the biological fluid with a reducing agent to obtain redox-active iron; (b) contacting the sample of the biological fluid with a nitrilotriacetate (NTA) at a concentration of 0.4-2 mM to mobilize non-transferrin bound iron including redox inactive and the redox active iron in the sample; (c) contacting the sample of the biological fluid of step (b) with an indicator including an iron binding moiety and fluorophore; and (d) detecting and quantifying a fluorescent signal of the fluorophore thereby quantifying the NTBI in the biological sample.
    Type: Application
    Filed: October 4, 2012
    Publication date: August 8, 2013
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Ioav Zvi CABANTCHIK, William Breuer
  • Molecules and methods using same for measuring non-transferrin bound iron
    Patent number: 7090995
    Abstract: A molecule suitable for use as an indicator of free iron levels in a biological sample, the molecule including an iron binding moeity and a signal generating moeity, wherein an intensity of the signal generated by the signal generating moeity is related to an amount of the iron bound by the iron binding moeity.
    Type: Grant
    Filed: October 30, 2002
    Date of Patent: August 15, 2006
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Ioav Zvi Cabantchik, William Breuer, Breno P. Esposito
  • Molecules and methods using same for measuring non-transferrin bound iron
    Publication number: 20030104491
    Abstract: A molecule suitable for use as an indicator of free iron levels in a biological sample, the molecule including an iron binding moeity and a signal generating moeity, wherein an intensity of the signal generated by the signal generating moeity is related to an amount of the iron bound by the iron binding moeity.
    Type: Application
    Filed: October 30, 2002
    Publication date: June 5, 2003
    Inventors: Ioav Zvi Cabantchik, William Breuer, Breno P. Esposito