Patents by Inventor Ion I. Mandoiu

Ion I. Mandoiu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Unbiased identification of tumor rejection mediating neoepitopes
    Patent number: 11920202
    Abstract: Described herein is an unbiased method of identifying tumor rejection mediating neoepitopes (TRMNs). Putative neoepitopes from a cancer cell exome sequence from a cancer patient are putative neoepitopes are unbiased by MHC binding and/or CD8T* reactivity. By plotting the putative neoepitope IC50s on one axis, and the non-mutated amino acid sequence IC50s on a perpendicular axis to provide a bivariate scatter plot, novel TRMNs are identified TRMNs the neoepitopes in the bivariate scatter plot which are in the space greater than 501 nM on the x-axis and greater than 501 nM on the y-axis. Peptides and nucleic acids for expressing peptides including the TRMNs are also described.
    Type: Grant
    Filed: April 8, 2021
    Date of Patent: March 5, 2024
    Assignee: UNIVERSITY OF CONNECTICUT
    Inventors: Pramod K. Srivastava, Ion I Mandoiu, Cory A Brennick, Mariam M George, Marmar Moussa
  • UNBIASED IDENTIFICATION OF TUMOR REJECTION MEDIATING NEOEPITOPES
    Publication number: 20210317533
    Abstract: Described herein is an unbiased method of identifying tumor rejection mediating neoepitopes (TRMNs). Putative neoepitopes from a cancer cell exome sequence from a cancer patient are putative neoepitopes are unbiased by MHC binding and/or CD8T* reactivity. By plotting the putative neoepitope IC50s on one axis, and the non-mutated amino acid sequence IC50s on a perpendicular axis to provide a bivariate scatter plot, novel TRMNs are identified TRMNs the neoepitopes in the bivariate scatter plot which are in the space greater than 501 nM on the x-axis and greater than 501 nM on the y-axis. Peptides and nucleic acids for expressing peptides including the TRMNs are also described.
    Type: Application
    Filed: April 8, 2021
    Publication date: October 14, 2021
    Inventors: Pramod K. Srivastava, Ion I Mandoiu, Cory A Brennick, Mariam M George, Marmar Moussa
  • Floorplan evaluation, global routing, and buffer insertion for integrated circuits
    Patent number: 7062743
    Abstract: A method and system for evaluating a floorplan and for defining a global buffered routing for an integrated circuit including constructing a graphical representation of the integrated circuit floorplan, including wire capacity and buffer capacity; formulating an integer linear program from said graphical representation; finding a solution to said integer linear program.
    Type: Grant
    Filed: September 24, 2003
    Date of Patent: June 13, 2006
    Assignee: The Regents of the University of California
    Inventors: Andrew B. Kahng, Christoph Albrecht, Ion I. Mandoiu, Alexander Z. Zelikovsky
  • Floorplan evaluation, global routing, and buffer insertion for integrated circuits
    Publication number: 20040117753
    Abstract: A method and system for evaluating a floorplan and for defining a global buffered routing for an integrated circuit including constructing a graphical representation of the integrated circuit floorplan, including wire capacity and buffer capacity; formulating an integer linear program from said graphical representation; finding a solution to said integer linear program.
    Type: Application
    Filed: September 24, 2003
    Publication date: June 17, 2004
    Applicant: The Regents of the University of California
    Inventors: Andrew B. Kahng, Christoph Albrecht, Ion I. Mandoiu, Alexander Z. Zelikovsky