Patents by Inventor Iontcho Radoslavov Vlahov

Iontcho Radoslavov Vlahov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS
    Publication number: 20220265841
    Abstract: The invention described herein pertains to the diagnosis, imaging, and/or treatment of pathogenic cell populations. In particular, the invention described herein pertains to the diagnosis, imaging, and/or treatment of diseases caused by PSMA expressing cells, such as prostate cancer cells, using compounds capable of targeting PSMA expressing cells.
    Type: Application
    Filed: May 5, 2022
    Publication date: August 25, 2022
    Inventors: Iontcho Radoslavov VLAHOV, Joseph Anand REDDY, Alicia BLOOMFIELD, Ryan DORTON, Melissa NELSON, Marilynn VETZEL, Christopher Paul LEAMON
  • Folate receptor binding conjugates of antifolates
    Patent number: 11219622
    Abstract: Conjugates of antifolates, releasable linkers, and drugs, and pharmaceutical compositions containing them are described. The conjugates are useful for treating diseases arising from pathogenic cell populations. Methods for treating such diseases are also described.
    Type: Grant
    Filed: June 13, 2019
    Date of Patent: January 11, 2022
    Assignees: Endocyte, Inc., Purdue Research Foundation
    Inventors: Christopher Paul Leamon, Iontcho Radoslavov Vlahov, Philip Stewart Low
  • SHIELDING AGENTS AND THEIR USE
    Publication number: 20210323985
    Abstract: The present disclosure relates to compounds useful as shielding agents for PSMA therapies. The present disclosure relates to methods of treating PSMA expressing cancers with one or more radiotherapeutics agents in combination with one or more shielding agents. The present disclosure relates to methods of imaging using one or more imaging agents containing a radionuclide in combination with one or more shielding agents. The present disclosure also relates to methods of making shielding agents.
    Type: Application
    Filed: September 19, 2019
    Publication date: October 21, 2021
    Inventors: Christopher Paul LEAMON, Iontcho Radoslavov VLAHOV
  • CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS
    Publication number: 20210154311
    Abstract: The invention described herein pertains to the diagnosis, imaging, and/or treatment of pathogenic cell populations. In particular, the invention described herein pertains to the diagnosis, imaging, and/or treatment of diseases caused by PSMA expressing cells, such as prostate cancer cells, using compounds capable of targeting PSMA expressing cells.
    Type: Application
    Filed: February 2, 2021
    Publication date: May 27, 2021
    Inventors: Iontcho Radoslavov VLAHOV, Joseph Anand REDDY, Alicia BLOOMFIELD, Ryan DORTON, Melissa NELSON, Marilynn VETZEL, Christopher Paul LEAMON
  • CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS
    Publication number: 20210154312
    Abstract: The invention described herein pertains to the diagnosis, imaging, and/or treatment of pathogenic cell populations. In particular, the invention described herein pertains to the diagnosis, imaging, and/or treatment of diseases caused by PSMA expressing cells, such as prostate cancer cells, using compounds capable of targeting PSMA expressing cells.
    Type: Application
    Filed: February 2, 2021
    Publication date: May 27, 2021
    Inventors: Iontcho Radoslavov VLAHOV, Joseph Anand REDDY, Alicia BLOOMFIELD, Ryan DORTON, Melissa NELSON, Marilynn VETZEL, Christopher Paul LEAMON
  • ANTIFOLATE CONJUGATES FOR TREATING INFLAMMATION
    Publication number: 20210069340
    Abstract: The present invention relates to compositions and methods for use in targeted drug delivery. More particularly, the invention is directed to cell-surface receptor binding conjugates containing hydrophilic spacer linkers for use in treating disease states caused by pathogenic cell populations and to methods and pharmaceutical compositions that use and include such conjugates.
    Type: Application
    Filed: July 16, 2020
    Publication date: March 11, 2021
    Inventors: Iontcho Radoslavov VLAHOV, Christopher Paul LEAMON, Fei YOU, Yingjuan J. LU, Paul Joseph KLEINDL
  • Conjugates for treating diseases caused by PSMA expressing cells
    Patent number: 10912840
    Abstract: The invention described herein pertains to the diagnosis, imaging, and/or treatment of pathogenic cell populations. In particular, the invention described herein pertains to the diagnosis, imaging, and/or treatment of diseases caused by PSMA expressing cells, such as prostate cancer cells, using compounds capable of targeting PSMA expressing cells.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: February 9, 2021
    Assignee: ENDOCYTE, INC.
    Inventors: Iontcho Radoslavov Vlahov, Joseph Anand Reddy, Alicia Bloomfield, Ryan Dorton, Melissa Nelson, Marilynn Vetzel, Christopher Paul Leamon
  • CONJUGATES CONTAINING HYDROPHILIC SPACER LINKERS
    Publication number: 20210024581
    Abstract: Described herein are compositions and methods for use in targeted drug delivery using cell receptor binding drug delivery conjugates containing hydrophilic spacer linkers for use in imaging, diagnosing, and/or treating diseases and disease states caused by pathogenic cell populations.
    Type: Application
    Filed: July 2, 2020
    Publication date: January 28, 2021
    Inventors: Christopher Paul Leamon, Iontcho Radoslavov Vlahov, Hari Krishna R. Santhapuram, Paul Joseph Kleindl, Kevin Yu Wang, Fei You
  • PBD CONJUGATES FOR TREATING DISEASES
    Publication number: 20200323991
    Abstract: The present disclosure relates to pyrrolobenzodiazepine (PBD) prodrugs and conjugates thereof. The present disclosure also relates to pharmaceutical compositions of the conjugates described herein, methods of making and methods of using the same.
    Type: Application
    Filed: March 29, 2017
    Publication date: October 15, 2020
    Inventors: Iontcho Radoslavov VLAHOV, Christopher Paul LEAMON, Longwu QI, Ning ZOU, Kevin Yu WANG, Albert E. FELTEN, Garth L. PARHAM, Fei YOU, Hari Krishna R. SANTHAPURAM, Spencer J. HAHN, Joseph Anand REDDY, Yingjuan J. LU, Leroy W. WHEELER, II
  • CONJUGATES FOR TREATING DISEASES
    Publication number: 20200289659
    Abstract: The present disclosure relates to pyrrolobenzodiazepine (PBD) prodrugs and conjugates thereof. The present disclosure also relates to pharmaceutical compositions of the conjugates described herein, methods of making and methods of using the same.
    Type: Application
    Filed: March 20, 2020
    Publication date: September 17, 2020
    Inventors: Iontcho Radoslavov Vlahov, Christopher Paul Leamon, Longwu QI, Yingcai Wang, Kevin Yu Wang, Ning Zou, Albert E. Felten
  • Conjugates containing hydrophilic spacer linkers
    Patent number: 10738086
    Abstract: Described herein are compositions and methods for use in targeted drug delivery using cell-surface receptor binding drug delivery conjugates containing hydrophilic spacer linkers for use in treating disease states caused by pathogenic cell populations.
    Type: Grant
    Filed: February 13, 2017
    Date of Patent: August 11, 2020
    Assignee: Endocyte Inc.
    Inventors: Christopher Paul Leamon, Iontcho Radoslavov Vlahov, Hari Krishna R. Santhapuram, Paul Joseph Kleindl, Kevin Yu Wang, Fei You
  • VITAMIN RECEPTOR DRUG DELIVERY CONJUGATES FOR TREATING INFLAMMATION
    Publication number: 20200155555
    Abstract: Described herein are compositions, methods, compounds, conjugates, and kits for use in targeted drug delivery using drug delivery conjugates containing hydrophilic spacer linkers for use in treating disease states caused by pathogenic cell populations, such as inflammatory cells.
    Type: Application
    Filed: November 13, 2019
    Publication date: May 21, 2020
    Inventors: Christopher Paul Leamon, Iontcho Radoslavov Vlahov, Yingjuan June Lu, Kevin Yu Wang, Fei You, Paul Joseph Kleindl, Hari Krishna R. Santhapuram
  • Folate Receptor Binding Conjugates of Antifolates
    Publication number: 20200147072
    Abstract: Conjugates of antifolates, releasable linkers, and drugs, and pharmaceutical compositions containing them are described. The conjugates are useful for treating diseases arising from pathogenic cell populations. Methods for treating such diseases are also described.
    Type: Application
    Filed: June 13, 2019
    Publication date: May 14, 2020
    Applicants: Purdue Research Foundation, Endocyte, Inc.
    Inventors: Christopher Paul Leamon, Iontcho Radoslavov Vlahov, Philip Stewart Low
  • DRUG DELIVERY CONJUGATES CONTAINING UNNATURAL AMINO ACIDS AND METHODS FOR USING
    Publication number: 20200121801
    Abstract: Described herein are drug delivery conjugates for targeted therapy. In particular, described herein are drug delivery conjugates that include polyvalent linkers comprising one or more unnatural amino acids that are useful for treating cancers and inflammatory diseases. The invention described herein pertains to drug delivery conjugates for targeted therapy. In particular, the invention described herein pertains to drug delivery conjugates that include polyvalent linkers comprising one or more unnatural amino acids.
    Type: Application
    Filed: August 23, 2019
    Publication date: April 23, 2020
    Inventors: Iontcho Radoslavov Vlahov, Christopher Paul Leamon
  • Conjugates for treating diseases
    Patent number: 10624972
    Abstract: The present disclosure relates to pyrrolobenzodiazepine (PBD) prodrugs and conjugates thereof. The present disclosure also relates to pharmaceutical compositions of the conjugates described herein, methods of making and methods of using the same.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: April 21, 2020
    Assignee: Endocyte, Inc.
    Inventors: Iontcho Radoslavov Vlahov, Christopher Paul Leamon, Longwu Qi, Yingcai Wang, Kevin Yu Wang, Ning Zou, Albert E. Felten
  • FOLATE CONJUGATE FOR USE IN TARGETING TUMOR ASSOCIATED MACROPHAGES
    Publication number: 20200038514
    Abstract: Methods are provided for treating cancers using a conjugate herein described as Conjugate 5, or a pharmaceutically acceptable salt thereof. Methods for treating cancers using Conjugate 5, or a pharmaceutically acceptable salt thereof, to target tumor associated macrophages are also described.
    Type: Application
    Filed: September 14, 2017
    Publication date: February 6, 2020
    Inventors: Iontcho Radoslavov VLAHOV, Christopher Paul LEAMON, Longwu QI, Ning ZOU, Kevin Yu WANG, Albert E. FELTEN, Garth L. PARHAM, Fei YOU, Hari Krishna R. SANTHAPURAM, Spencer J. HAHN, Joseph Anand REDDY, Yingjuan J. LU, Leroy W. WHEELER, II
  • Vitamin receptor drug delivery conjugates for treating inflammation
    Patent number: 10500204
    Abstract: Described herein are compositions, methods, compounds, conjugates, and kits for use in targeted drug delivery using drug delivery conjugates containing hydrophilic spacer linkers for use in treating disease states caused by pathogenic cell populations, such as inflammatory cells.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: December 10, 2019
    Assignee: Endocyte, Inc.
    Inventors: Christopher Paul Leamon, Iontcho Radoslavov Vlahov, Yingjuan June Lu, Kevin Yu Wang, Fei You, Paul Joseph Kleindl, Hari Krishna R. Santhapuram
  • CCK2R-drug conjugates
    Patent number: 10500286
    Abstract: The disclosure provided herein pertains to CCK2R-drug conjugates. In particular, the disclosure pertains to CCK2R-drug conjugates that target the delivery of drugs to a mammalian recipient. Also described are methods of making and using CCK2R-drug conjugates.
    Type: Grant
    Filed: August 10, 2016
    Date of Patent: December 10, 2019
    Assignee: Endocyte, Inc.
    Inventors: Garth L. Parham, Melissa Nelson, Marilynn Vetzel, Christina M. Dircksen, Joseph Anand Reddy, Christopher Paul Leamon, Iontcho Radoslavov Vlahov
  • CONJUGATES FOR TREATING DISEASES CAUSED BY PSMA EXPRESSING CELLS
    Publication number: 20190314515
    Abstract: The invention described herein pertains to the diagnosis, imaging, and/or treatment of pathogenic cell populations. In particular, the invention described herein pertains to the diagnosis, imaging, and/or treatment of diseases caused by PSMA expressing cells, such as prostate cancer cells, using compounds capable of targeting PSMA expressing cells.
    Type: Application
    Filed: May 28, 2019
    Publication date: October 17, 2019
    Inventors: Iontcho Radoslavov VLAHOV, Joseph Anand REDDY, Alicia BLOOMFIELD, Ryan DORTON, Melissa NELSON, Marilynn VETZEL, Christopher Paul LEAMON
  • Folate receptor binding conjugates of antifolates
    Patent number: 10363250
    Abstract: Conjugates of antifolates, releasable linkers, and drugs, and pharmaceutical compositions containing them are described. The conjugates are useful for treating diseases arising from pathogenic cell populations. Methods for treating stroll diseases are also described.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: July 30, 2019
    Assignees: Endocyte, Inc., Purdue Research Foundation
    Inventors: Christopher Paul Leamon, Iontcho Radoslavov Vlahov, Philip Stewart Low