Patents by Inventor Iosef Manascu

Iosef Manascu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for the preparation of rocuronium bromide and intermediates thereof
    Patent number: 7579461
    Abstract: A novel process for preparing (2?,3?,5?,16?,17?)-17-acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl) androstane, a known intermediate in the synthesis of the skeletal muscle relaxant rocuronium bromide, is disclosed.
    Type: Grant
    Filed: January 13, 2005
    Date of Patent: August 25, 2009
    Assignee: Chemagis Ltd.
    Inventors: Eliezer Adar, David Sondack, Oded Friedman, Iosef Manascu, Tamir Fizitzki, Boris Freger, Oded Arad, Alexander Weisman, Joseph Kaspi
  • Processes for the preparation and purification of rocuronium bromide
    Publication number: 20060058276
    Abstract: Processes are provided herein for the preparation of pure rocuronium bromide and for the purification of impure rocuronium bromide obviating the need for column chromatography and that can be easily, conveniently and inexpensively scaled-up.
    Type: Application
    Filed: July 14, 2005
    Publication date: March 16, 2006
    Inventors: Oded Friedman, Oded Arad, Iosef Manascu, Tamir Fizitzki, Boris Freger, Joseph Kaspi
  • Processes for preparing stabilized, highly pure rocuronium bromide
    Publication number: 20060058275
    Abstract: Processes are provided herein for the preparation and purification of stable, powdered solids comprising substantially pure rocuronium bromide.
    Type: Application
    Filed: July 14, 2005
    Publication date: March 16, 2006
    Inventors: Oded Friedman, Oded Arad, Iosef Manascu, Tamir Fizitzki, Joseph Kaspi
  • Process for the preparation of terbinafine and salts thereof
    Publication number: 20060004230
    Abstract: A process for the preparation of Terbinafine and salts thereof by reacting 1-chloro-6,6-dimethylhept-2-en-4-yne and N-methyl-N-(1-naphthylmethyl)amine in a basic aqueous medium is disclosed. Also disclosed is a process for the preparation of 1-chloro-6,6-dimethylhept-2-en-4-yne.
    Type: Application
    Filed: June 30, 2004
    Publication date: January 5, 2006
    Inventors: Joseph Kaspi, Oded Arad, Oded Friedman, Iosef Manascu, Tamir Fizitzki, Edna Danon
  • Processes for the preparation of rocuronium bromide and intermediates thereof
    Publication number: 20050159398
    Abstract: A novel process for preparing (2?,3?,5?,16?,17?)-17-acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl)androstane, a known intermediate in the synthesis of the skeletal muscle relaxant rocuronium bromide, is disclosed.
    Type: Application
    Filed: January 13, 2005
    Publication date: July 21, 2005
    Inventors: Eliezer Adar, David Sondack, Oded Friedman, Iosef Manascu, Tamir Fizitzki, Boris Freger, Oded Arad, Alexander Weisman, Joseph Kaspi