Patents by Inventor Iouri Voitsekhovski

Iouri Voitsekhovski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Conversion of oxycodone base to oxycodone hydrochloride
    Patent number: 10227354
    Abstract: Synthetic methods are provided for preparation of oxycodone and salts thereof with an improved impurity profile. Thebaine is converted to 14-hydroxycodeinone sulfate intermediate to minimize a 7,8-dihydro-8,14-dihydroxycodeinone impurity. Efficient methods for conversion of oxycodone base to oxycodone hydrochloride are provided to minimize 14-hydroxycodeinone impurity in the final product.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: March 12, 2019
    Assignee: Cody Laboratories, Inc.
    Inventors: Zinovy Itov, Vladimir F. Kuznetsov, Iouri Voitsekhovski
  • METHOD FOR CATALYTIC PREPARATION OF HYDROMORPHONE, HYDROCODONE, AND OTHER OPIATES
    Publication number: 20190048017
    Abstract: Methods are provided for efficient preparation of hydromorphone or hydrocodone by redox isomerization of morphine or codeine allylic alcohols, respectively, using transition metal aminophosphine catalysts formed in situ.
    Type: Application
    Filed: August 22, 2018
    Publication date: February 14, 2019
    Inventors: Gnel Mkrtchyan, Iouri Voitsekhovski, Scott Michaels
  • Method for catalytic preparation of hydromorphone, hydrocodone, and other opiates
    Patent number: 10081636
    Abstract: Methods are provided for efficient preparation of hydromorphone or hydrocodone by redox isomerization of morphine or codeine allylic alcohols, respectively, using transition metal aminophosphine catalysts formed in situ.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: September 25, 2018
    Assignee: Cody Laboratories, Inc.
    Inventors: Gnel Mkrtchyan, Iouri Voitsekhovski, Scott Michaels
  • METHOD FOR CATALYTIC PREPARATION OF HYDROMORPHONE, HYDROCODONE, AND OTHER OPIATES
    Publication number: 20180009821
    Abstract: Methods are provided for efficient preparation of hydromorphone or hydrocodone by redox isomerization of morphine or codeine allylic alcohols, respectively, using transition metal aminophosphine catalysts formed in situ.
    Type: Application
    Filed: July 7, 2017
    Publication date: January 11, 2018
    Inventors: Gnel Mkrtchyan, Iouri Voitsekhovski, Scott Michaels
  • Preparation of oxycodone base form 14-hydroxycodeinone sulfate
    Patent number: 9309257
    Abstract: Synthetic methods are provided for preparation of oxycodone and salts thereof with an improved impurity profile. Thebaine is converted to 14-hydroxycodeinone sulfate intermediate to minimize a 7,8-dihydro-8,14-dihydroxycodeinone impurity. Efficient methods for conversion of oxycodone base to oxycodone hydrochloride are provided to minimize 14-hydroxycodeinone impurity in the final product.
    Type: Grant
    Filed: August 21, 2014
    Date of Patent: April 12, 2016
    Assignee: Cody Laboratories, Inc.
    Inventors: Zinovy Itov, Vladimir F. Kuznetsov, Iouri Voitsekhovski
  • Preparation of 14-hydroxycodeinone sulfate
    Patent number: 9233972
    Abstract: Synthetic methods are provided for preparation of oxycodone and salts thereof with an improved impurity profile. Thebaine is converted to 14-hydroxycodeinone sulfate intermediate to minimize a 7,8-dihydro-8,14-dihydroxycodeinone impurity. Efficient methods for conversion of oxycodone base to oxycodone hydrochloride are provided to minimize 14-hydroxycodeinone impurity in the final product.
    Type: Grant
    Filed: August 14, 2014
    Date of Patent: January 12, 2016
    Assignee: Cody Laboratories, Inc.
    Inventors: Zinovy Itov, Vladimir F. Kuznetsov, Iouri Voitsekhovski
  • Preparation of 14-hydroxycodeinone sulfate
    Patent number: 9108976
    Abstract: Synthetic methods are provided for preparation of oxycodone and salts thereof with an improved impurity profile. Thebaine is converted to 14-hydroxycodeinone sulfate intermediate to minimize a 7,8-dihydro-8,14-dihydroxycodeinone impurity. Efficient methods for conversion of oxycodone base to oxycodone hydrochloride are provided to minimize 14-hydroxycodeinone impurity in the final product.
    Type: Grant
    Filed: August 21, 2014
    Date of Patent: August 18, 2015
    Assignee: Cody Laboratories, Inc.
    Inventors: Zinovy Itov, Vladimir F. Kuznetsov, Iouri Voitsekhovski
  • Preparation of 14-hydroxycodeinone sulfate
    Patent number: 9090620
    Abstract: Synthetic methods are provided for preparation of oxycodone and salts thereof with an improved impurity profile. Thebaine is converted to 14-hydroxycodeinone sulfate intermediate to minimize a 7,8-dihydro-8,14-dihydroxycodeinone impurity. Efficient methods for conversion of oxycodone base to oxycodone hydrochloride are provided to minimize 14-hydroxycodeinone impurity in the final product.
    Type: Grant
    Filed: August 21, 2014
    Date of Patent: July 28, 2015
    Assignee: Cody Laboratories, Inc.
    Inventors: Zinovy Itov, Vladimir F. Kuznetsov, Iouri Voitsekhovski
  • Synthesis of oxycodone hydrochloride
    Patent number: 9062062
    Abstract: Synthetic methods are provided for preparation of oxycodone and salts thereof with an improved impurity profile. Thebaine is converted to 14-hydroxycodeinone sulfate intermediate to minimize a 7,8-dihydro-8,14-dihydroxycodeinone impurity. Efficient methods for conversion of oxycodone base to oxycodone hydrochloride are provided to minimize 14-hydroxycodeinone impurity in the final product.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: June 23, 2015
    Assignee: Cody Laboratories, Inc.
    Inventors: Zinovy Itov, Vladimir F. Kuznetsov, Iouri Voitsekhovski
  • PREPARATION OF 14-HYDROXYCODEINONE SULFATE
    Publication number: 20150166554
    Abstract: Synthetic methods are provided for preparation of oxycodone and salts thereof with an improved impurity profile. Thebaine is converted to 14-hydroxycodeinone sulfate intermediate to minimize a 7,8-dihydro-8,14-dihydroxycodeinone impurity. Efficient methods for conversion of oxycodone base to oxycodone hydrochloride are provided to minimize 14-hydroxycodeinone impurity in the final product.
    Type: Application
    Filed: August 14, 2014
    Publication date: June 18, 2015
    Inventors: Zinovy Itov, Vladimir F. Kuznetsov, Iouri Voitsekhovski
  • CONVERSION OF OXYCODONE BASE TO OXYCODONE HYDROCHLORIDE
    Publication number: 20150166552
    Abstract: Synthetic methods are provided for preparation of oxycodone and salts thereof with an improved impurity profile. Thebaine is converted to 14-hydroxycodeinone sulfate intermediate to minimize a 7,8-dihydro-8,14-dihydroxycodeinone impurity. Efficient methods for conversion of oxycodone base to oxycodone hydrochloride are provided to minimize 14-hydroxycodeinone impurity in the final product.
    Type: Application
    Filed: December 18, 2013
    Publication date: June 18, 2015
    Applicant: Cody Laboratories, Inc.
    Inventors: Zinovy Itov, Vladimir F. Kuznetsov, Iouri Voitsekhovski
  • PREPARATION OF 14-HYDROXYCODEINONE SULFATE
    Publication number: 20150166555
    Abstract: Synthetic methods are provided for preparation of oxycodone and salts thereof with an improved impurity profile. Thebaine is converted to 14-hydroxycodeinone sulfate intermediate to minimize a 7,8-dihydro-8,14-dihydroxycodeinone impurity. Efficient methods for conversion of oxycodone base to oxycodone hydrochloride are provided to minimize 14-hydroxycodeinone impurity in the final product.
    Type: Application
    Filed: August 21, 2014
    Publication date: June 18, 2015
    Inventors: Zinovy Itov, Vladimir F. Kuznetsov, Iouri Voitsekhovski
  • PREPARATION OF 14-HYDROXYCODEINONE SULFATE
    Publication number: 20150166556
    Abstract: Synthetic methods are provided for preparation of oxycodone and salts thereof with an improved impurity profile. Thebaine is converted to 14-hydroxycodeinone sulfate intermediate to minimize a 7,8-dihydro-8,14-dihydroxycodeinone impurity. Efficient methods for conversion of oxycodone base to oxycodone hydrochloride are provided to minimize 14-hydroxycodeinone impurity in the final product.
    Type: Application
    Filed: August 21, 2014
    Publication date: June 18, 2015
    Inventors: Zinovy Itov, Vladimir F. Kuznetsov, Iouri Voitsekhovski
  • SYNTHESIS OF OXYCODONE HYDROCHLORIDE
    Publication number: 20150166553
    Abstract: Synthetic methods are provided for preparation of oxycodone and salts thereof with an improved impurity profile. Thebaine is converted to 14-hydroxycodeinone sulfate intermediate to minimize a 7,8-dihydro-8,14-dihydroxycodeinone impurity. Efficient methods for conversion of oxycodone base to oxycodone hydrochloride are provided to minimize 14-hydroxycodeinone impurity in the final product.
    Type: Application
    Filed: December 18, 2013
    Publication date: June 18, 2015
    Applicant: Cody Laboratories, Inc.
    Inventors: Zinovy Itov, Vladimir F. Kuznetsov, Iouri Voitsekhovski
  • PREPARATION OF 14-HYDROXYCODEINONE SULFATE
    Publication number: 20150166557
    Abstract: Synthetic methods are provided for preparation of oxycodone and salts thereof with an improved impurity profile. Thebaine is converted to 14-hydroxycodeinone sulfate intermediate to minimize a 7,8-dihydro-8,14-dihydroxycodeinone impurity. Efficient methods for conversion of oxycodone base to oxycodone hydrochloride are provided to minimize 14-hydroxycodeinone impurity in the final product.
    Type: Application
    Filed: August 21, 2014
    Publication date: June 18, 2015
    Inventors: Zinovy Itov, Vladimir F. Kuznetsov, Iouri Voitsekhovski
  • Preparation of 14-hydroxycodeinone sulfate
    Patent number: 8846923
    Abstract: Synthetic methods are provided for preparation of oxycodone and salts thereof with an improved impurity profile. Thebaine is converted to 14-hydroxycodeinone sulfate intermediate to minimize a 7,8-dihydro-8,14-dihydroxycodeinone impurity. Efficient methods for conversion of oxycodone base to oxycodone hydrochloride are provided to minimize 14-hydroxycodeinone impurity in the final product.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: September 30, 2014
    Assignee: Cody Laboratories, Inc.
    Inventors: Zinovy Itov, Vladimir F. Kuznetsov, Iouri Voitsekhovski