Patents by Inventor Ippei Inoue
Ippei Inoue has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240058473Abstract: The present invention provides a highly controlled complex comprising an antibody and ferritin particles. More specifically, the present invention provides the inventions of a complex or salt thereof comprising (A) one IgG antibody and (B) two human ferritin particles comprising one or more human ferritin H chains linked thereto; and methods for producing the same.Type: ApplicationFiled: September 14, 2023Publication date: February 22, 2024Applicant: Ajinomoto Co., Inc.Inventors: Kei YAMADA, Yutaka MATSUDA, Ippei INOUE, Natsuki SHIKIDA, Kazutaka SHIMBO
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Publication number: 20240018272Abstract: the present invention provides a method for producing a protein having a supramolecular structure in which a bioactive substance is encapsulated, comprising: (I) bringing a subunit of a protein, which forms a supramolecular structure, a bioactive substance, and a solution for forming the protein having the supramolecular structure from the subunit into contact with one another in a flow micro mixer.Type: ApplicationFiled: September 5, 2023Publication date: January 18, 2024Applicant: AJINOMOTO CO., INC.Inventors: Yuichi NAKAHARA, Yuta ENDO, Ippei INOUE, Takahiro OKASORA, Junko YAMAZAKI HOSHIDA, Sachise KARAKAWA
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Publication number: 20230279063Abstract: Controlling the number of modifying groups introduced into a surface of ferritin affords a modified ferritin containing a human ferritin H chain, in which the human ferritin H chain contains a modifying group that is covalently bonded specifically to a cysteine residue at position 91 and/or position 103 according to a reference position of a natural human ferritin H chain.Type: ApplicationFiled: December 7, 2022Publication date: September 7, 2023Applicant: Ajinomoto Co., Inc.Inventors: Kei YAMADA, Ippei INOUE, Natsuki SHIKIDA, Kazutaka SHIMBO
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Publication number: 20230079759Abstract: A compatibility prediction method includes predicting compatibility between a prediction target food and a prediction target drink using: a model for predicting the compatibility between the prediction target food and the prediction target drink, and measurements that are values related to predetermined information obtained when a measuring instrument measures aroma components of the prediction target food and the prediction target drink or calculations calculated based on the measurements.Type: ApplicationFiled: November 17, 2022Publication date: March 16, 2023Applicant: Ajinomoto Co., Inc.Inventors: Takashi HASHIMOTO, Yuichi NAKAHARA, Akira IMAIZUMI, Ippei INOUE, Hiroshi UMISHIO, Megumi YAMADA
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Publication number: 20220401560Abstract: Peptide-encapsulating ferritins including a peptide that is composed of 3 to 19 amino acid residues and satisfies the following requirement: a) ?10.2?X?5.Type: ApplicationFiled: March 3, 2022Publication date: December 22, 2022Applicant: Ajinomoto Co., Inc.Inventors: Ippei INOUE, Kenichiro ITO, Mayumi TOKUYAMA
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Publication number: 20210253651Abstract: An organic compound-encapsulating ferritin may be prepared by: (1) mixing an organic compound with ferritin in a buffer to obtain a mixture of the organic compound and ferritin; and (2) incubating the mixture in the buffer, wherein the buffer has a pH of 3 or more and less than 13, and the buffer has a pH of 3 or more and less than 7 when the organic compound has a pKa less than 7, and has a pH of 6 or more and less than 13 when the organic compound has a pKa of 7 or more.Type: ApplicationFiled: April 28, 2021Publication date: August 19, 2021Applicant: Ajinomoto Co., Inc.Inventors: Ippei INOUE, Yuichi NAKAHARA
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Publication number: 20200392193Abstract: Fusion proteins, comprising (a) a ferritin monomer, and (b) a functional peptide inserted at a flexible linker region between a-helices in a B region and a C region of the ferritin monomer, and multimers of such a fusion protein and having an internal cavity, are promising for applications such as new drug delivery systems (DDS) and preparation of electronic devices.Type: ApplicationFiled: August 20, 2020Publication date: December 17, 2020Applicant: Ajinomoto Co., Inc.Inventor: Ippei INOUE
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Patent number: 9187570Abstract: The present invention provides means useful for making devices, materials and the like that are excellent in photocatalytic activity, electric property or the like. Specifically, the present invention provides a fusion protein comprising a polypeptide portion capable of forming a multimer having an internal cavity, and a first peptide portion capable of binding to a first target substance and a second peptide portion capable of binding to a second target substance; a multimer of the fusion protein; a complex comprising the multimer of the fusion protein; and the like.Type: GrantFiled: June 21, 2013Date of Patent: November 17, 2015Assignee: Ajinomoto Co., Ltd.Inventors: Ippei Inoue, Ichiro Yamashita, Bin Zheng, Hisashi Yasueda, Yukiharu Uraoka, Yasuaki Ishikawa
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Patent number: 8993279Abstract: A method for producing an L-amino acid is described, which is characterized by culturing a Vibrio bacterium capable of producing the L-amino acid in a culture medium to produce and accumulate the L-amino acid in the culture medium and collecting the L-amino acid from the culture medium.Type: GrantFiled: July 31, 2009Date of Patent: March 31, 2015Assignee: Ajinomoto Co., Inc.Inventors: Yoko Asakura, Ippei Inoue, Hisashi Yasueda
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Publication number: 20140150855Abstract: A functional material having excellent photocatalytic activity, electric characteristics and the like is provided. A porous structure body 10 comprises a first target material 20 and an aggregate body 30 formed by aggregation of the first material. The aggregate body 30 adheres to the first target material and is located so as to surround the first target material. The aggregate body has a plurality of first pores 32 unevenly distributed near the first target material in the aggregate body and a plurality of second pores 34 scattered over the aggregate body.Type: ApplicationFiled: February 10, 2014Publication date: June 5, 2014Applicant: AJINOMOTO CO., INC.Inventors: Ippei INOUE, Ichiro Yamashita, Bin Zheng, Hisashi Yasueda, Yukiharu Uraoka, Yasuaki Ishikawa
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Publication number: 20140045247Abstract: The present invention provides means useful for making devices, materials and the like that are excellent in photocatalytic activity, electric property or the like. Specifically, the present invention provides a fusion protein comprising a polypeptide portion capable of forming a multimer having an internal cavity, and a first peptide portion capable of binding to a first target substance and a second peptide portion capable of binding to a second target substance; a multimer of the fusion protein; a complex comprising the multimer of the fusion protein; and the like.Type: ApplicationFiled: October 16, 2013Publication date: February 13, 2014Applicant: AJINOMOTO CO., INC.Inventors: IPPEI INOUE, ICHIRO YAMASHITA, BIN ZHENG, HISASHI YASUEDA, YUKIHARU URAOKA, YASUAKI ISHIKAWA
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Publication number: 20120276598Abstract: A method for efficiently producing an L-amino acid, especially L-lysine, by using a ?-proteobacterium is provided. In a method for producing an L-amino acid comprising culturing a bacterium belonging to ?-Proteobacteria and having an ability to produce an L-amino acid, for example, an Enterobacteriaceae bacterium such as Escherichia coli, in a medium containing glycerol as a carbon source to produce and accumulate the L-amino acid in the medium, and collecting the L-amino acid from the medium, a bacterium modified so that the activity of the Cnu protein is reduced is used as the bacterium.Type: ApplicationFiled: May 4, 2012Publication date: November 1, 2012Inventors: Ippei Inoue, Hisashi Yasueda
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Publication number: 20120156736Abstract: L-Lysine is produced by culturing in a medium a Vibrio bacterium which has an ability to produce L-lysine, and has been modified so that an activity of a protein encoded by the fucO gene is reduced to produce and accumulate L-lysine in the medium or cells of the bacterium, and collecting L-lysine from the medium or cells.Type: ApplicationFiled: February 2, 2012Publication date: June 21, 2012Inventors: Ippei Inoue, Hisashi Yasueda
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Publication number: 20100028958Abstract: A method for producing an L-amino acid is described, which is characterized by culturing a Vibrio bacterium capable of producing the L-amino acid in a culture medium to produce and accumulate the L-amino acid in the culture medium and collecting the L-amino acid from the culture medium.Type: ApplicationFiled: July 31, 2009Publication date: February 4, 2010Inventors: Yoko Asakura, Ippei Inoue, Hisashi Yasueda
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Patent number: 7092154Abstract: An apparatus is provided with a cell culture container having a cell culture region made of a hole formed on a substrate, a semi-permeable membrane covering a top plane of the cell culture region and a culture medium replacement part provided over the semi-permeable membrane, a mechanism for supplying a cell culture medium into the cell culture container, and a microscopic optical mechanism for enabling long-term observation of the cell within the cell culture region. This apparatus makes it possible to culture a cell group originating from a particular single cell, to perform culture and observation while identifying cells to be subjected to interaction during the process of culturing cells, and observe a difference in variation between the particular cell and other cells. There is also provided a mechanism which makes it possible to collect only a cell assuming a particular state and perform analysis or biochemical measurement of a gene of the cell, an expressed mRNA and the like.Type: GrantFiled: November 22, 2001Date of Patent: August 15, 2006Assignee: Japan Science and Technology CorporationInventors: Kenji Yasuda, Kunihiko Kaneko, Tetsuya Yomo, Ippei Inoue, Yuichi Wakamoto
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Publication number: 20040067482Abstract: Novel technical means is provided with a cell culture container having a cell culture region made of a hole formed on a substrate, a semi-permeable membrane covering a top plane of the cell culture region and a culture medium replacement part provided over the semi-permeable membrane, means for supplying a cell culture medium into the cell culture container, and microscopic optical means for enabling long-term observation of the cell within the cell culture region. The novel technical means makes it possible to culture a cell group originating from a particular single cell, to perform culture and observation, while identifying cells to be subjected to interaction during the process of culturing cells, to spray a substance which interacts with cells, for example, a drug such as a signal substance onto only a particular cell in a cell group which is being cultured so that cells are cultured at a constant cell density, and observe a difference in variation between the particular cell and other calls.Type: ApplicationFiled: October 7, 2003Publication date: April 8, 2004Inventors: Kenji Yasuda, Kunihiko Kaneko, Tetsuya Yomo, Ippei Inoue, Yuichi Wakamoto