Patents by Inventor Irene Bosch
Irene Bosch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11320433Abstract: The present invention provides matched antibody pairs for the specific detection of one or more of the four dengue virus serotypes in a biological sample that may contain one or more of such dengue virus serotypes. Each matched antibody pair is capable of detecting not more than one serotype of dengue virus NS1 protein that may be present in the sample and will not cross react with other serotypes that may be present in the sample. Multiple matched pairs may be used to detect one or more dengue virus serotypes that may be present in a sample. Such matched pair antibodies, facilitate the development of confirmatory in vitro diagnostic tests such as sandwich immunoassays, that detect and distinguish the presence of one or more dengue virus serotypes in a biological sample, preferably a sample derived from human subject.Type: GrantFiled: December 9, 2019Date of Patent: May 3, 2022Assignees: Massachusetts Institute of Technology, The United States of America as Represented by the Secretary of the Department of Health and Human ServicesInventors: Irene Bosch, Kimberly Hamad-Schifferli, Jose Gomez-Marquez, Helena dePuig Guixe, Lee Gehrke
-
Publication number: 20200363415Abstract: The present invention provides matched antibody pairs for the specific detection of one or more of the four dengue virus serotypes in a biological sample that may contain one or more of such dengue virus serotypes. Each matched antibody pair is capable of detecting not more than one serotype of dengue virus NS1 protein that may be present in the sample and will not cross react with other serotypes that may be present in the sample. Multiple matched pairs may be used to detect one or more dengue virus serotypes that may be present in a sample. Such matched pair antibodies, facilitate the development of confirmatory in vitro diagnostic tests such as sandwich immunoassays, that detect and distinguish the presence of one or more dengue virus serotypes in a biological sample, preferably a sample derived from human subject.Type: ApplicationFiled: December 9, 2019Publication date: November 19, 2020Inventors: Irene Bosch, Kimberly Hamad-Schifferli, Jose Gomez-Marquez, Helena dePuig Guixe, Lee Gehrke
-
Patent number: 10551381Abstract: The present invention provides matched antibody pairs for the specific detection of one or more of the four dengue virus serotypes in a biological sample that may contain one or more of such dengue virus serotypes. Each matched antibody pair is capable of detecting not more than one serotype of dengue virus NS1 protein that may be present in the sample and will not cross react with other serotypes that may be present in the sample. Multiple matched pairs may be used to detect one or more dengue virus serotypes that may be present in a sample. Such matched pair antibodies, facilitate the development of confirmatory in vitro diagnostic tests such as sandwich immunoassays, that detect and distinguish the presence of one or more dengue virus serotypes in a biological sample, preferably a sample derived from human subject.Type: GrantFiled: February 10, 2017Date of Patent: February 4, 2020Assignees: Massachusetts Institute of Technology, The United States of America as Represented by the Secretary of the Department of Health and Human ServicesInventors: Irene Bosch, Kimberly Hamad-Schifferli, Jose Gomez-Marquez, Helena de Puig, Lee Gehrke
-
Publication number: 20180372755Abstract: The present invention provides a multiplexed immunoassay which leverages stockpiled antibodies to detect whether a patient has been infected with an emerging disease which does not have specific antibodies raised against it (FIG. 1). The assay is preferably designed as a paper-based assay, which allows diagnosis at point of care (POC) and readout by eye or mobile phone. Paper-based rapid diagnostic tests (RDTs) are convenient, robust, and can be read out within minutes. The immunoassay of the invention combines the strategic use of nanoparticles of assorted colors with readily available stockpiled antibodies to one or more biomarkers of disease, particularly viral diseases.Type: ApplicationFiled: June 22, 2018Publication date: December 27, 2018Inventors: Lee Gehrke, Helena de Puig Guixe, Irene Bosch, Jose Gomez-Marquez, Kimberly Hamad-Schifferli
-
Publication number: 20170233460Abstract: The present invention provides matched antibody pairs for the specific detection of one or more of the four dengue virus serotypes in a biological sample that may contain one or more of such dengue virus serotypes. Each matched antibody pair is capable of detecting not more than one serotype of dengue virus NS1 protein that may be present in the sample and will not cross react with other serotypes that may be present in the sample. Multiple matched pairs may be used to detect one or more dengue virus serotypes that may be present in a sample. Such matched pair antibodies, facilitate the development of confirmatory in vitro diagnostic tests such as sandwich immunoassays, that detect and distinguish the presence of one or more dengue virus serotypes in a biological sample, preferably a sample derived from human subject.Type: ApplicationFiled: February 10, 2017Publication date: August 17, 2017Inventors: Irene Bosch, Kimberly Hamad-Schifferli, Jose Gomez-Marquez, Helena de Puig, Lee Gehrke
-
Publication number: 20170234866Abstract: The present invention provides a lateral flow multiplex assay strip, and lateral flow assay systems and kits comprising the assay strips of the invention and methods of using the assay strip and systems and kits to detect the levels of two or more target analytes that may be present in a liquid sample, wherein the two more target analytes are detectable at a single test area of the assay.Type: ApplicationFiled: February 11, 2016Publication date: August 17, 2017Inventors: Kimberly Hamad-Schifferli, Irene Bosch, Chun-Wan Yen, Helena de Puig, Justina O. Tam, Lee Gehrke
-
Patent number: 9488613Abstract: Exemplary embodiments provide diagnostic devices, systems and methods for determining the presence or absence of one or more markers or characteristics in one or more samples. An exemplary diagnostic device may display a first two-dimensional machine-readable output to indicate the presence or absence of a first characteristic in a sample. Similarly, the exemplary diagnostic device may display a second two-dimensional machine-readable output to indicate the presence or absence of a second characteristic in a sample. An image capture device may be used to automatically detect the two-dimensional machine-readable output appearing in the diagnostic device. A computational device may be used to automatically determine whether the presence or absence of the first characteristic and/or the second characteristic based on the two-dimensional machine-readable output displayed in the diagnostic device.Type: GrantFiled: August 30, 2013Date of Patent: November 8, 2016Assignee: Massachusetts Institute of TechnologyInventors: Irene Bosch, Kimberly S. Hamad-Schifferli, Lee Gehrke, Nevan Clancy Hanumara, Jacqueline Linnes, David Wood, Jose F. Gomez-Marquez
-
Publication number: 20140246334Abstract: Exemplary embodiments provide diagnostic devices, systems and methods for determining the presence or absence of one or more markers or characteristics in one or more samples. An exemplary diagnostic device may display a first two-dimensional machine-readable output to indicate the presence or absence of a first characteristic in a sample. Similarly, the exemplary diagnostic device may display a second two-dimensional machine-readable output to indicate the presence or absence of a second characteristic in a sample. An image capture device may be used to automatically detect the two-dimensional machine-readable output appearing in the diagnostic device. A computational device may be used to automatically determine whether the presence or absence of the first characteristic and/or the second characteristic based on the two-dimensional machine-readable output displayed in the diagnostic device.Type: ApplicationFiled: August 30, 2013Publication date: September 4, 2014Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Irene Bosch, Kimberly S. Hamad-Schifferli, Lee Gehrke, Nevan Clancy Hanumara, Jacqueline Linnes, David Wood, Jose F. Gomez-Marquez
-
Publication number: 20110045501Abstract: A cytokine receptor family member (ST2), which has membrane bound as well as soluble bound forms, is elevated in patients during acute phase of dengue fever. Moreover, secondary cases of dengue fever had even more pronounced elevation of ST2 in serum in comparison to primary cases. One possible role of soluble ST2 might be to act as decoy for membrane bound ST2 signaling, therefore, promoting a proinflammatory response in secondary dengue infections. Alternatively, ST2 may act as a biomarker for endothelial damage such that ST2 may be useful in identifying severe dengue infections, specifically in dengue hemorrhagic fever.Type: ApplicationFiled: January 8, 2009Publication date: February 24, 2011Inventors: Irene Bosch, Becerra Aniuska