Patents by Inventor Irene E. Kochevar
Irene E. Kochevar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20220256839Abstract: One aspect of the invention provides a method for preparing a vein graft. The method includes: applying a tissue passivation agent to a resected anatomical vessel; placing the resected anatomical vessel in a chamber; and allowing the tissue passivation agent to cross-link while the resected anatomical vessel is in the chamber.Type: ApplicationFiled: May 4, 2022Publication date: August 18, 2022Applicant: The General Hospital CorporationInventors: William G. Austen, JR., Michael C. McCormack, Robert W. Redmond, Irene E. Kochevar
-
Publication number: 20220249221Abstract: One aspect of the invention provides a method of preventing or reducing stenosis in a subject. The method includes implanting a passivated graft comprising vein into an artery. The implanting of the graft replaces and/or bypasses a diseased segment of the artery. The passivated grail including vein is prepared by exposing the exterior surface of the passivated graft comprising vein to a tissue structure stabilizing agent (“TSSA”) under conditions sufficient to promote cross-linking of proteins within the vein.Type: ApplicationFiled: April 28, 2022Publication date: August 11, 2022Applicant: The General Hospital CorporationInventors: William G. Austen, JR., Michael McCormack, Robert W. Redmond, Irene E. Kochevar
-
Patent number: 11350625Abstract: One aspect of the invention provides a method for preparing a vein graft. The method includes: applying a tissue passivation agent to a resected anatomical vessel; placing the resected anatomical vessel in a chamber; and allowing the tissue passivation agent to cross-link while the resected anatomical vessel is in the chamber.Type: GrantFiled: April 2, 2019Date of Patent: June 7, 2022Assignee: The General Hospital CorporationInventors: William G. Austen, Jr., Michael C. McCormack, Robert W. Redmond, Irene E. Kochevar
-
Patent number: 11337792Abstract: One aspect of the invention provides a method of preventing or reducing stenosis in a subject. The method includes implanting a passivated graft comprising vein into an artery. The implanting of the graft replaces and/or bypasses a diseased segment of the artery. The passivated graft including vein is prepared by exposing the exterior surface of the passivated graft comprising vein to a tissue structure stabilizing agent (“TSSA”) under conditions sufficient to promote cross-linking of proteins within the vein.Type: GrantFiled: November 18, 2019Date of Patent: May 24, 2022Assignee: The General Hospital CorporationInventors: William G. Austen, Jr., Michael McCormack, Robert W. Redmond, Irene E. Kochevar
-
Publication number: 20210001142Abstract: One aspect of the invention provides an apparatus including: a fluid-impermeable membrane configured to contain a fluid and be placed in the cavity; a light emitter provided within the membrane; and a fluid provided within the membrane, wherein the fluid scatters light emitted by the light emitter such that the intensity of the light is substantially uniform over the inner surface of the cavity proximal to the membrane.Type: ApplicationFiled: February 4, 2020Publication date: January 7, 2021Applicant: The General Hospital CorporationInventors: Michael C. McCormack, Robert Redmond, William G. Austen, Irene E. Kochevar
-
Publication number: 20200078159Abstract: One aspect of the invention provides a method of preventing or reducing stenosis in a subject. The method includes implanting a passivated graft comprising vein into an artery. The implanting of the graft replaces and/or bypasses a diseased segment of the artery. The passivated graft including vein is prepared by exposing the exterior surface of the passivated graft comprising vein to a tissue structure stabilizing agent (“TSSA”) under conditions sufficient to promote cross-linking of proteins within the vein.Type: ApplicationFiled: November 18, 2019Publication date: March 12, 2020Applicant: The General Hospital CorporationInventors: William G. Austen, JR., Michael McCormack, Robert W. Redmond, Irene E. Kochevar
-
Patent number: 10549112Abstract: One aspect of the invention provides an apparatus including: a fluid-impermeable membrane configured to contain a fluid and be placed in the cavity; a light emitter provided within the membrane; and a fluid provided within the membrane, wherein the fluid scatters light emitted by the light emitter such that the intensity of the light is substantially uniform over the inner surface of the cavity proximal to the membrane.Type: GrantFiled: September 9, 2015Date of Patent: February 4, 2020Assignee: The General Hospital CorporationInventors: Michael C. McCormack, Robert Redmond, William G. Austen, Jr., Irene E. Kochevar
-
Patent number: 10478284Abstract: Methods of tissue passivation are described herein for use in preserving normal tissue architecture, reducing post-surgical inflammation, and reducing or preventing the development of pathogenic collagen bundles and adhesions following surgical procedures. Passivated tissues prepared in accordance with these methods are useful in a variety of therapies including, e.g., cardiac bypass surgery, hemodialysis, etc.Type: GrantFiled: January 20, 2015Date of Patent: November 19, 2019Assignee: The General Hospital CorporationInventors: William G. Austen, Jr., Michael McCormack, Robert W. Redmond, Irene E. Kochevar
-
Publication number: 20190223432Abstract: One aspect of the invention provides a method for preparing a vein graft. The method includes: applying a tissue passivation agent to a resected anatomical vessel; placing the resected anatomical vessel in a chamber; and allowing the tissue passivation agent to cross-link while the resected anatomical vessel is in the chamber.Type: ApplicationFiled: April 2, 2019Publication date: July 25, 2019Applicant: The General Hospital CorporationInventors: William G. Austen, JR., Michael C. McCormack, Robert W. Redmond, Irene E. Kochevar
-
Publication number: 20160151638Abstract: One aspect of the invention provides an apparatus including: a fluid-impermeable membrane configured to contain a fluid and be placed in the cavity; a light emitter provided within the membrane; and a fluid provided within the membrane, wherein the fluid scatters light emitted by the light emitter such that the intensity of the light is substantially uniform over the inner surface of the cavity proximal to the membrane.Type: ApplicationFiled: September 9, 2015Publication date: June 2, 2016Inventors: Michael C. McCormack, Robert Redmond, William G. Austen, JR., Irene E. Kochevar
-
Publication number: 20160120173Abstract: One aspect of the invention provides a vessel treatment system including: a housing defining at least one opening adapted and configured to receive an anatomical vessel; and a humidifier in communication with the housing, the humidifier adapted and configured to introduce humidity into the housing to prevent desiccation of the anatomical vessel. Another aspect of the invention provides a kit including: the vessel treatment system as described herein; and a passivation agent. Another aspect of the invention provides a method for preparing a vein graft. The method includes: applying a tissue passivation agent to a resected anatomical vessel; and placing the resected anatomical vessel in a humidified chamber while the tissue passivation agent cures.Type: ApplicationFiled: January 11, 2016Publication date: May 5, 2016Inventors: William G. Austen, JR., Michael McCormack, Robert W. Redmond, Irene E. Kochevar
-
Publication number: 20150134049Abstract: Methods of tissue passivation are described herein for use in preserving normal tissue architecture, reducing post-surgical inflammation, and reducing or preventing the development of pathogenic collagen bundles and adhesions following surgical procedures. Passivated tissues prepared in accordance with these methods are useful in a variety of therapies including, e.g., cardiac bypass surgery, hemodialysis, etc.Type: ApplicationFiled: January 20, 2015Publication date: May 14, 2015Inventors: William G. Austen, JR., Michael McCormack, Robert W. Redmond, Irene E. Kochevar
-
Publication number: 20140217649Abstract: The present invention relates to a field of biocompatible membranes, tubes and conduits which comprising a photosensitizer which is capable of being crosslinked to form a three dimensional structure which can be implanted into a subject to assist in tissue bonding and nerve maintenance and development. Methods of making such membranes, tubes and conduits and kits comprising them are also described.Type: ApplicationFiled: January 10, 2014Publication date: August 7, 2014Applicant: The General Hospital CorporationInventors: Irene E. Kochevar, Robert W. Redmond, Anne C. O'Neill, Mark Randolph
-
Publication number: 20130158342Abstract: Photochemical tissue boding methods for bonding neural tissues include the application of a photosensitizer to a tissue and/or tissue graft, followed by irradiation with electromagnetic energy to produce a tissue seal. The methods are useful for tissue adhesion, such as in wound closure, tissue grafting, skin grafting, musculoskeletal tissue repair, ligament or tendon repair, neural repair, blood vessel repair and corneal repair.Type: ApplicationFiled: July 6, 2012Publication date: June 20, 2013Applicant: The General Hospital CorporationInventors: Barbara Chan, Timothy Shane Johnson, Irene E. Kochevar, Mark Randolph, Robert W. Redmond, Jonathan M. Winograd
-
Patent number: 8215314Abstract: Photochemical tissue boding methods for bonding neural tissues include the application of a photosensitizer to a tissue and/or tissue graft, followed by irradiation with electromagnetic energy to produce a tissue seal. The methods are useful for tissue adhesion, such as in wound closure, tissue grafting, skin grafting, musculoskeletal tissue repair, ligament or tendon repair, neural repair, blood vessel repair and corneal repair.Type: GrantFiled: December 9, 2003Date of Patent: July 10, 2012Assignee: The General Hospital CorporationInventors: Barbara Chan, Timothy Shane Johnson, Irene E. Kochevar, Mark Randolph, Robert W. Redmond, Jonathan M. Winograd
-
Publication number: 20120136387Abstract: Photochemical tissue bonding methods include the application of a photosensitizer to a tissue and/or tissue graft, followed by irradiation with electromagnetic energy to produce a tissue seal. The methods are useful for tissue adhesion, such as in wound closure, tissue grafting, skin grafting, musculoskeletal tissue repair, ligament or tendon repair and corneal repair.Type: ApplicationFiled: September 23, 2011Publication date: May 31, 2012Applicant: The General Hospital CorporationInventors: Robert W. Redmond, Irene E. Kochevar
-
Publication number: 20120095455Abstract: Photochemical tissue bonding methods include the application of a photosensitizer to a tissue, e.g., cornea, followed by irradiation with electromagnetic energy to produce a tissue seal. The methods are useful for wound repair, or other tissue repair.Type: ApplicationFiled: December 21, 2011Publication date: April 19, 2012Applicant: The General Hospital CorporationInventors: Robert W. Rodmond, Irene E. Kochevar, Dimitri Azar
-
Publication number: 20120035527Abstract: The exemplary embodiments of the present invention provides exemplary methods for adhering biological membranes to luminal anatomical structures using photosensitizing agents and electromagnetic energy. The exemplary embodiments of the present invention also provides method for stabilizing luminal anatomical structures. Further, exemplary embodiments of the present invention provide arrangements for coupling to a luminal anatomical structure.Type: ApplicationFiled: October 2, 2008Publication date: February 9, 2012Applicant: THE GENERAL HOSPITAL CORPORATIONInventors: Guillermo Tearney, Brett Bouma, Robert W. Redmond, Irene E. Kochevar
-
Patent number: 8092490Abstract: Photochemical tissue bonding methods include the application of a photosensitizer to a tissue and/or tissue graft, followed by irradiation with electromagnetic energy to produce a tissue seal. The methods are useful for tissue adhesion, such as in wound closure, tissue grafting, skin grafting, musculoskeletal tissue repair, ligament or tendon repair and corneal repair.Type: GrantFiled: August 16, 2005Date of Patent: January 10, 2012Assignee: The General Hospital CorporationInventors: Robert W. Redmond, Irene E. Kochevar
-
Publication number: 20110152898Abstract: The present invention relates to a field of biocompatible membranes, tubes and conduits which comprising a photosensitizer which is capable of being crosslinked to form a three dimensional structure which can be implanted into a subject to assist in tissue bonding and nerve maintenance and development. Methods of making such membranes, tubes and conduits and kits comprising them are also described.Type: ApplicationFiled: May 8, 2009Publication date: June 23, 2011Applicant: The General Hospital CorporationInventors: Irene E. Kochevar, Robert W. Redmond, Anne C. O'Neill, Mark Randolph